Characterization of Sialic Acid Index of Plasma Apolipoprotein J and Phosphatidylethanol During Alcohol Detoxification—A Pilot Study

Wurst, Friedrich Martin; Thon, Natasha; Weinmann, Wolfgang; Tippetts, Scott; Marques, Paul R.; Hahn, Judith A.; Alling, Christer; Aradóttir, Steina; Hartmann, Susanne; Lakshman, Raj

doi:10.1111/j.1530-0277.2011.01618.x

Cited by 26 publications

(24 citation statements)

References 64 publications

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“…In clinical studies conducted on chronic heavy drinkers, PEth was found to be detectable in blood up to 28 days after sobriety [32,40–46]. In 15 alcoholics following a detoxification program, the mean half-life of blood PEth was 4.0 ± 0.7 days with a range of 3.0–5.3 days [47].…”

Section: Resultsmentioning

confidence: 99%

“…Nine of the above-mentioned clinical trials used HPLC-ELSD for total PEth quantification in blood utilizing as an interpretative cut-off the lower limit of quantification (LOQ) of the analytical method used for PEth determination, that is: 0.22 μM [40,46,47,70,77], 0.30 μM [44,45,75] or 0.8 μM [43]. With the above-mentioned cut-offs, the diagnostic sensitivities of PEth were very high, varying from 98% [40] to 100% [44–46,57].…”

Section: Resultsmentioning

confidence: 99%

“…With the above-mentioned cut-offs, the diagnostic sensitivities of PEth were very high, varying from 98% [40] to 100% [44–46,57]. …”

Section: Resultsmentioning

confidence: 99%

“…Differing from the traditional indirect biomarkers used for diagnosing a chronic excessive drinking behavior (MCV, AST, ALT, GGT, and CDT), blood PEth concentration seems not to be influenced by age, gender, other ingested substances or non alcohol-associated diseases, such as hypertension, kidney and/or liver diseases [44–46,72]. For these reasons, PEth is considered to perform better than MCV and GGT, both in terms of sensitivity and specificity, for detecting chronic excessive drinking behaviors [40–43,45,46].…”

Section: Resultsmentioning

confidence: 99%

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Phosphatidylethanol in Blood as a Marker of Chronic Alcohol Use: A Systematic Review and Meta-Analysis

Viel

Boscolo‐Berto

Cecchetto

et al. 2012

IJMS

214

188

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The present paper aims at a systematic review of the current knowledge on phosphatidylethanol (PEth) in blood as a direct marker of chronic alcohol use and abuse. In March 2012, the search through “MeSH” and “free-text” protocols in the databases Medline/PubMed, SCOPUS, Web of Science, and Ovid/Embase, combining the terms phosphatidylethanol and alcohol, provided 444 records, 58 of which fulfilled the inclusion criteria and were used to summarize the current evidence on the formation, distribution and degradation of PEth in human blood: (1), the presence and distribution of different PEth molecular species (2), the most diffused analytical methods devoted to PEth identification and quantization (3), the clinical efficiency of total PEth quantification as a marker of chronic excessive drinking (4), and the potential utility of this marker for identifying binge drinking behaviors (5). Twelve papers were included in the meta-analysis and the mean (M) and 95% confidence interval (CI) of total PEth concentrations in social drinkers (DAI ≤ 60 g/die; M = 0.288 μM; CI 0.208–0.367 μM) and heavy drinkers (DAI > 60 g/die; M = 3.897 μM; CI 2.404–5.391 μM) were calculated. The present analysis demonstrates a good clinical efficiency of PEth for detecting chronic heavy drinking.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…With the above-mentioned cut-offs, the diagnostic sensitivities of PEth were very high, varying from 98% [40] to 100% [44–46,57]. …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Phosphatidylethanol in Blood as a Marker of Chronic Alcohol Use: A Systematic Review and Meta-Analysis

Viel

Boscolo‐Berto

Cecchetto

et al. 2012

IJMS

214

188

View full text Add to dashboard Cite

show abstract

“…PEth is an alcohol marker with high sensitivity in groups with excessive alcohol consumption (96-100%) [13,14,25]. The clinical sensitivity has been more varied in groups with low or moderate alcohol consumption, largely due to differences in sensitivity between analytical methods [14,16,26,27].…”

Section: Discussionmentioning

confidence: 99%

Alcohol Consumption in Obese Patients Before and After Gastric Bypass as Assessed with the Alcohol Marker Phosphatidylethanol (PEth)

Walther

Brodén²,

Isaksson

et al. 2018

OBES SURG

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Introduction Roux-en-Y gastric bypass (RYGB) causes more rapid and enhanced absorption of alcohol. RYGB patients have also been reported to use more inpatient care for alcohol-related disease than do patients after other bariatric procedures. The present study was designed to evaluate alcohol consumption level before and after gastric bypass using a sensitive and specific alcohol biomarker. Materials and Methods Two separate consecutive groups of patients and a group of healthy blood donors, as reference group, were included in the study. Alcohol intake was assessed using the alcohol marker phosphatidylethanol (PEth) at preoperative baseline and at 1 and 2 years postoperatively. In the first patient group (n = 133), neither surgeon nor patient was informed about the results of PEth testing. In the second group (n = 214), PEth results above 0.30 μmol/L were considered to indicate excessive alcohol consumption and led to preoperative alcohol counseling. The groups were followed for 2 and 1 year, respectively. Results PEth results were significantly lower in both patient groups at baseline as well as postoperatively compared with the reference group. In both patient groups, there was a significant increase in PEth values at postoperative follow-up compared to baseline. Conclusions Several physiological changes postoperatively have to be considered when interpreting PEth results in obese patients with dramatic weight reductions. According to results for PEth, obese patients treated with bariatric surgery would seem to have lower alcohol consumption compared with the reference group. Although slightly increasing their PEth values postoperatively, the RYGB patients did not reach the PEth values of the reference group.

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Biological State Marker for Alcohol Consumption

Wurst¹,

Thon²,

Weinmann³

et al. 2014

Textbook of Addiction Treatment: International Perspectives

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Characterization of Sialic Acid Index of Plasma Apolipoprotein J and Phosphatidylethanol During Alcohol Detoxification—A Pilot Study

Abstract: Our preliminary data suggest that SIJ and PEth might hold potential as markers of heavy ethanol intake.

Cited by 26 publications

References 64 publications

Phosphatidylethanol in Blood as a Marker of Chronic Alcohol Use: A Systematic Review and Meta-Analysis

Phosphatidylethanol in Blood as a Marker of Chronic Alcohol Use: A Systematic Review and Meta-Analysis

Alcohol Consumption in Obese Patients Before and After Gastric Bypass as Assessed with the Alcohol Marker Phosphatidylethanol (PEth)

Biological State Marker for Alcohol Consumption

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