Durability is an issue for selective catalytic reduction (SCR) catalysts due to their susceptibility to sulfur and water poisoning. In this study, Nano-Ce 10 -PSDC HF /ZrO 2 was prepared by the hydrothermal method using sintering dust, and the impact of SO 2 or water vapor on its SCR performance was investigated. The denitrification performance of Nano-Ce 10 -PSDC HF /ZrO 2 was better than that of 0.25-Ce 10 -PSDC HF /ZrO 2 prepared by the impregnation method in the entire temperature interval from 80 to 400 °C. The highest denitrification rate of 93.6% was achieved at 280 °C. Nano-Ce 10 -PSDC HF /ZrO 2 had a smaller particle size and uniform dispersion but also formed a high concentration of Ce 3+ and adsorbed oxygen O α on the surface. Additionally, it showed better resistance to water and sulfur than 0.25-Ce 10 -PSDC HF /ZrO 2 . Even when exposed to 8% H 2 O and 400 ppm SO 2 , the denitrification rate of Nano-Ce 10 -PSDC HF /ZrO 2 remained at 82.1% after 4 h. SO 2 is more toxic to SCR catalysts than H 2 O. The effect of water on catalyst activity is partially reversible. Deactivation of SCR by SO 2 is primarily caused by the formation of ammonium sulfate species, with some contribution from competitive adsorption between SO 2 and NO x . In conclusion, the Nano-Ce 10 -PSDC HF /ZrO 2 catalyst exhibited the best SCR performance, with water and sulfur resistance, and effectively utilized sintering dust, which has potential application value.