Characterization of site-specific biomechanical properties of human meniscus—Importance of collagen and fluid on mechanical nonlinearities

Danso, Elvis K.; Mäkelä, Janne; Tanska, Petri; Mononen, Mika E.; Honkanen, Juuso T. J.; Jurvelin, Jukka S.; Töyräs, Juha; Julkunen, Petro; Korhonen, Rami K.

doi:10.1016/j.jbiomech.2015.01.048

Cited by 88 publications

(78 citation statements)

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“…Low fibrillar stiffness, high permeability, and reasonably high nonfibrillar matrix modulus help tissue deformations and dissipation under prolonged loading conditions. It may be that the meniscus, which was not considered here, may be the elastic shock absorber in the knee while the tibial plateau cartilage contributes primarily to the viscous dissipation of loads (Danso et al, 2015;Gaugler et al, 2014;Pereira et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage

Mäkelä

Han

Herzog

et al. 2015

Journal of Biomechanics

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In this study, fibril-reinforced poroelastic (FRPE) modeling was used for rabbit knee after anterior cruciate ligament transection (ACLT) to assess how the mechanical properties of collagen, proteoglycans, and fluid in articular cartilage change in early osteoarthritis, and how site-specific these changes are. Unilateral ACLT was performed in eight skeletally mature, female New Zealand white rabbits. A separate control (CTRL) group consisted of knee joints of five non-operated rabbits. Animals were sacrificed at four weeks after ACLT and cartilage-on-bone samples from femoral groove, medial and lateral femoral condyles, and tibial plateaus were harvested. A stress-relaxation protocol in indentation geometry was applied and the FRPE model was fitted to the experimental force-time curve by minimizing the mean absolute error between experiment and simulation. The optimized parameters were: fibril network modulus (Ef), representing the collagen network; non-fibrillar matrix modulus (Enf), representing the PG matrix; and permeability (k), representing fluid flow. Permeability was increased significantly in the ACLT group compared to the CTRL group knees at all sites except for the medial tibial plateau. ACLT also caused a decrease in the Ef at all sites except for the medial and lateral tibial plateaus. The Enf of the ACLT group knees was altered only for the lateral femoral condyle. The results of this study suggest that early osteoarthritis primarily affects cartilage permeability and impairs the collagen network stiffness in a site-specific manner. These findings from early osteoarthritis indicate that fluid flow velocity in articular cartilage may change prior to quantifiable structural alterations in the tissue.

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Section: Discussionmentioning

confidence: 99%

Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage

Mäkelä

Han

Herzog

et al. 2015

Journal of Biomechanics

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show abstract

“…In vitro experiments are often conducted so that data from FE models can be curve-fit to the experimentally generated data and the material properties extracted, through so called inverse FE techniques. Using such methods, Danso et al (2015) suggested that the medial meniscus is more inhomogeneous than the lateral meniscus and that the nonlinearities in material properties are due to the density of collagen fibers and the associated fluid content. In contrast, it would appear that the surface layer of the meniscus is relatively homogeneous (Li et al, 2015) and poro-viscoelastic, unlike the deep zones of the tissue.…”

mentioning

confidence: 99%

Meniscus mechanics and mechanobiology

Donahue

Fisher

Maher

2015

Journal of Biomechanics

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“…1) achieved using optimization process. model with this linearly increasing fibril network modulus with strain was able to reproduce experimental step-wise stressrelaxation curves of human meniscus (Danso et al, 2015).…”

Section: Discussionmentioning

confidence: 89%

Highly nonlinear stress-relaxation response of articular cartilage in indentation: Importance of collagen nonlinearity

Mäkelä

Korhonen

2016

Journal of Biomechanics

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Characterization of site-specific biomechanical properties of human meniscus—Importance of collagen and fluid on mechanical nonlinearities

Cited by 88 publications

References 50 publications

Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage

Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage

Meniscus mechanics and mechanobiology

Highly nonlinear stress-relaxation response of articular cartilage in indentation: Importance of collagen nonlinearity

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