Highly nonlinear stress-relaxation response of articular cartilage in indentation: Importance of collagen nonlinearity

Mäkelä, Janne; Korhonen, Rami K.

doi:10.1016/j.jbiomech.2016.04.002

Cited by 21 publications

(7 citation statements)

References 39 publications

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“…) and bending radius of the collagen fibrils in the middle zone ( ), see supplementary materials for an example. The collagen content was implemented with a relative fibril volume density ( , which was estimated from the FTIR data (Supplemental figure 5), as described previously (Mäkelä and Korhonen, 2016) by fitting a line to the normalized collagen content (Supplemental figure 2).…”

Section: Implementation Of Measured Compositionmentioning

confidence: 99%

Interrelationship of cartilage composition and chondrocyte mechanics after a partial meniscectomy in the rabbit knee joint – Experimental and numerical analysis

Ronkainen

Tanska

Fick

et al. 2019

Journal of Biomechanics

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Site-specific and depth-dependent properties of cartilage were implemented within a finite element (FE) model to determine if compositional or structural changes in the tissue could explain site-specific alterations of chondrocyte deformations due to cartilage loading in rabbit knee joints 3 days after a partial meniscectomy (PM). Depth-dependent proteoglycan (PG) content, collagen content and collagen orientation in the cartilage extracellular matrix (ECM), and PG content in the pericellular matrix (PCM) were assessed with microscopic and spectroscopic methods. Patellar, femoral groove and samples from both the lateral and medial compartments of the femoral condyle and tibial plateau were extracted from healthy controls and from the partial menisectomy group. For both groups and each knee joint site, axisymmetric FE models with measured properties were generated. Experimental cartilage loading was applied in the simulations and chondrocyte volumes were compared to the experimental values. ECM and PCM PG loss occurred within the superficial cartilage layer in the PM group at all locations, except in the lateral tibial plateau. Collagen content and orientation were not significantly altered due to the PM. The FE simulations predicted similar chondrocyte volume changes and group differences as obtained experimentally. Loss of PCM fixed charge density (FCD) decreased cell volume loss, as observed in the medial femur and medial tibia, whereas loss of ECM FCD increased cell volume loss, as seen in the patella, femoral groove and lateral femur. The model outcome, cell volume change, was also sensitive to applied tissue geometry, collagen fibril orientation and loading conditions.

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Section: Implementation Of Measured Compositionmentioning

confidence: 99%

Interrelationship of cartilage composition and chondrocyte mechanics after a partial meniscectomy in the rabbit knee joint – Experimental and numerical analysis

Ronkainen

Tanska

Fick

et al. 2019

Journal of Biomechanics

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“…During rapid loading, the fibrillar network dominates the dynamic stiffness, relative to the nonfibrillar network 24,32,33 . Under these conditions, the tensile stiffness of the network resists the fluid pressurization.…”

Section: Discussionmentioning

confidence: 99%

Functional effects of an interpenetrating polymer network on articular cartilage mechanical properties

Mäkelä

Cooper

Korhonen

et al. 2018

Osteoarthritis and Cartilage

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“…R 2 is the coefficient of determination. In preliminary testing, we tested also other objective functions, such as minimizing the normalized mean squared error (nMSE) [50][51][52] and minimizing nMSE with an additional weighting factor for the peak forces [53,54]. We found the current objective function to result in best fits on our data, capturing well the peak forces and the relaxation behaviour.…”

Section: Materials Parameter Optimizationmentioning

confidence: 98%

Structure, composition and fibril-reinforced poroviscoelastic properties of bovine knee ligaments and patellar tendon

Ristaniemi

Regmi

Mondal

et al. 2021

J. R. Soc. Interface.

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Tissue-level stress-relaxation of ligaments and tendons in the toe region is characterized by fast and long-term relaxations and an increase in relaxation magnitude with strain. Characterizing the compositional and structural origins of these phenomena helps in the understanding of mechanisms of ligament and tendon function and adaptation in health and disease. A three-step tensile stress-relaxation test was conducted on dumbbell-shaped pieces of bovine knee ligaments and patellar tendon (PT) ( n = 10 knees). Their mechanical behaviour was characterized by a fibril-reinforced poroviscoelastic material model, able to describe characteristic times and magnitudes of fast and long-term relaxations. The crimp angle and length of tissues were measured with polarized light microscopy, while biochemical contents were determined by colorimetric biochemical methods. The long-term relaxation time was longer in the anterior cruciate ligament (ACL) and PT compared with collateral ligaments ( p < 0.05). High hydroxyproline content predicted greater magnitude and shorter time of both fast and long-term relaxation. High uronic acid content predicted longer time of long-term relaxation, whereas high crimp angle predicted higher magnitude of long-term relaxation. ACL and PT are better long-term stabilizers than collateral ligaments. The long-term relaxation behaviour is affected or implied by proteoglycans and crimp angle, possibly relating to slow structural reorganization of the tissue.

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Highly nonlinear stress-relaxation response of articular cartilage in indentation: Importance of collagen nonlinearity

Cited by 21 publications

References 39 publications

Interrelationship of cartilage composition and chondrocyte mechanics after a partial meniscectomy in the rabbit knee joint – Experimental and numerical analysis

Interrelationship of cartilage composition and chondrocyte mechanics after a partial meniscectomy in the rabbit knee joint – Experimental and numerical analysis

Functional effects of an interpenetrating polymer network on articular cartilage mechanical properties

Structure, composition and fibril-reinforced poroviscoelastic properties of bovine knee ligaments and patellar tendon

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