1994
DOI: 10.1016/0198-8859(94)90023-x
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Characterization of skin-infiltrating cells during acute graft-versus-host disease following bone marrow transplantation using unrelated marrow donors

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Cited by 7 publications
(5 citation statements)
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“…Data from rat models showed that T-cell depletion of bone marrow grafts using anti-␣␤ TCR mAb could retain engraftment potential and avoid GVHD (Huang et al 2001;Neipp et al 1999). Similarly in human studies (Liu et al 1996;Nikaein et al 1994), ␣␤ + T cells were found to be the major lymphocytes infiltrating in the tissues of GVHD lesions. Therefore, it might be interesting to further clarify whether G-CSF could influence the repertoire of ␣␤ + T cells (TRAV and TRBV repertoire), thus influencing the alloreactivity of T cells and mediating GVHD.…”
Section: Discussionsupporting
confidence: 55%
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“…Data from rat models showed that T-cell depletion of bone marrow grafts using anti-␣␤ TCR mAb could retain engraftment potential and avoid GVHD (Huang et al 2001;Neipp et al 1999). Similarly in human studies (Liu et al 1996;Nikaein et al 1994), ␣␤ + T cells were found to be the major lymphocytes infiltrating in the tissues of GVHD lesions. Therefore, it might be interesting to further clarify whether G-CSF could influence the repertoire of ␣␤ + T cells (TRAV and TRBV repertoire), thus influencing the alloreactivity of T cells and mediating GVHD.…”
Section: Discussionsupporting
confidence: 55%
“…␥␦ + T cells, which represent approximately 5-10% of peripheral T cells and are predominantly CD3 + CD4 − CD8 − T cells, are able to recognize non-peptide antigens in a non-MHC-restricted fashion and play an indispensable role in pathogen elimination and immune regulation (Huang et al 2001;Li et al 2007). Recently, some studies have demonstrated that ␣␤ + T cells are the primary immune effector cells involving in the pathology of GVHD (Huang et al 2001;Liu et al 1996;Neipp et al 1999;Nikaein et al 1994). Data from rat models showed that T-cell depletion of bone marrow grafts using anti-␣␤ TCR mAb could retain engraftment potential and avoid GVHD (Huang et al 2001;Neipp et al 1999).…”
Section: Discussionmentioning
confidence: 99%
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“…[32][33][34] Recipients of matched unrelated transplants are gens. TCR␥␦ + T cells represent approximately 2% of peripheral T cells and are predominantly CD4 − CD8 − .…”
Section: Multivariate Analysis Of Chronic Gvhd Relapse and Survivalmentioning
confidence: 99%