Characterization of Sol–Gel Combustion Derived Akermanite and Merwinite for its Antibacterial Activity and Osteogenic Differentiation of Mesenchymal Stem Cells

Krishnamurithy, G.; Choudhary, Rajan; Сенатов, Ф.С.; Raghavendran, Hanumantha Rao Balaji; Murali, Malliga Raman; Kamarul, Tunku; Suresh, Anushree; Abraham, Jayanthi; Samuel, Sumant; Livingston, Abel; Swamiappan, Sasikumar

doi:10.1007/s12633-023-02362-1

Cited by 3 publications

(2 citation statements)

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“…According to the MTT test, cells adhere better on the surface of porous ceramics treated at a temperature of 1050 • C. Increasing the temperature to 1250 • C decreases cell viability, with a larger number of dead cells (seen in red) observed on the fluorescence image. This temperatureinduced behavior is consistent with the data reported by Venkatraman et al [26] which showed a decrease in cell viability with increasing sintering temperature.…”

Section: Resultssupporting

confidence: 92%

“…For this reason, it is necessary to increase these mechanical strengths by reducing the open porosity and finding alternative routes to processing these ceramics. Venkatraman et al [ 26 ] found that the use of high temperatures affects morphology, surface roughness, porosity, and particle size but also causes a decrease in bioactivity. Therefore, reducing the sintering temperatures of these ceramics is of interest.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication and Characterization of Porous Diopside/Akermanite Ceramics with Prospective Tissue Engineering Applications

et al. 2023

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Tissue engineering requires new materials that can be used to replace damaged bone parts. Since hydroxyapatite, currently widely used, has low mechanical resistance, silicate ceramics can represent an alternative. The aim of this study was to obtain porous ceramics based on diopside (CaMgSi2O6) and akermanite (Ca2MgSi2O7) obtained at low sintering temperatures. The powder synthesized by the sol-gel method was pressed in the presence of a porogenic agent represented by commercial sucrose in order to create the desired porosity. The ceramic bodies obtained after sintering thermal treatment at 1050 °C and 1250 °C, respectively, were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR) to determine the chemical composition. The open porosity was situated between 32.5 and 34.6%, and the compressive strength had a maximum value of 11.4 MPa for the samples sintered at 1250 °C in the presence of a 20% wt porogenic agent. A cell viability above 70% and the rapid development of an apatitic phase layer make these materials good candidates for use in hard tissue engineering.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%