Characterization of spray dried bioadhesive metformin microparticles for oromucosal administration

A focus on mucoadhesive polymers and their application in buccal dosage forms

“…Indeed, the administration of nano-and microparticles allows distributing the drug onto larger mucosal surface areas leading to a comparatively higher drug uptake. A spray-drying approach was used to prepare chitosan-metformin microparticles for oromucosal drug delivery [129] with different chitosan:metformin ratios and chitosan molecular weights. A recently developed ex vivo flow retention model simulating oromucosal conditions by the use of porcine mucosa as the biological substrate was employed to evaluate the bioadhesive properties of spray dried microparticles.…”

Physicochemical aspects involved in methotrexate release kinetics from biodegradable spray-dried chitosan microparticles

“…CH is a biodegradable linear copolymer composed of Dglucosamine and N-acetyl-D-glucosamine monomers in different ratios, which gives it interesting properties. In aqueous media this polycationic material can interact with negative charges of mucosal epithelium and enhance bioavailability of drugs limited by a short residence time at the site of absorption [2,3]. Bioadhesion, biocompatibility and biodegradability characteristics allow CH to be used in microencapsulation to obtain new drug delivery systems.…”

p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing

“…We previously reported that compromised decidual health and function in p53 d/d females are reflected in premature decidual senescence, increased rates of spontaneous PTB, and highly increased response to a small dose of LPS (4). To assess the effects of Met treatment on decidual health, we first examined the status of γH2AX associated with DNA damage followed by staining of senescence-associated β-galactosidase (SA-β-gal), 2 markers of decidual senescence (25) metformin (Met) is widely used as a first-line therapy for diabetes to increase insulin sensitivity (7,8). Its off-label use in ovulation induction in women with polycystic ovary syndrome is supported by its safety reports in pregnancy (9,10).…”