Characterization of the Antidiabetic Role of <i>Parkinsonia aculeata</i> (Caesalpineaceae)

Leite, Antônio Cesar Rios; Araújo, Tiago Gomes; Carvalho, Bruno M.; Maia, Maria Bernadete Sousa; Lima, Vera Lúcia de Menezes

doi:10.1155/2011/692378

Cited by 21 publications

(12 citation statements)

References 52 publications

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“…The final yield of the hydroethanolic extract partitioned with ethyl acetate of P. aculeata aerial parts (HEPa/EtOAc) was 5.2/50 g of the dried powdered aerial parts. Based on three previous studies by our group [10,11,15], for pharmacological assays, a fresh dilution of lyophilized HEPa/EtOAc extract in vehicle (distilled water) was prepared on the day of treatment and administered by gavage at the doses of 125 and 250 mg/kg b.w. in a fixed volume of 0.2 mL.…”

Section: Preparation Of Plant Extractmentioning

confidence: 99%

“…In this regard, the present study demonstrates that P. aculeata is effective in improving insulin resistance in a mouse model of obesity and this effect seems to involve the antioxidant mechanisms through the increase in PPARc/ CuZn-SOD axis expression. In addition to these important effects, we can assume that P. aculeata is toxicologically safe, since a previous study has demonstrated that the oral administration of a maximum dose of 5 g/kg of HEPa/ EtOAc did not result in any lethality or observable behavioral changes [10].…”

Section: Data Presented By the World Health Organization (Who)mentioning

confidence: 99%

“…It is traditionally described to treat fever, malaria, rheumatism [9], and hyperglycemia [10,11]. The use of natural antioxidants has been associated with reduced risks of diabetes, cancer, cardiovascular disease, and other illnesses associated with aging [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Treatment with Parkinsonia aculeata combats insulin resistance-induced oxidative stress through the increase in PPARγ/CuZn-SOD axis expression in diet-induced obesity mice

et al. 2016

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Parkinsonia aculeata L. (Caesalpiniaceae) is a traditional ethnomedicine and has been used for the empiric treatment of hyperglycemia, without scientific background. Mechanistic analyses at molecular level from the antioxidant mechanism observed by P. aculeata are required. Herein the effects of the treatment by hydroethanolic extract partitioned with ethyl acetate of P. aculeata aerial parts (HEPa/EtOAc) in mice fed a high-fat diet that share many obesity phenotypes with humans were evaluated. The animals were treated orally with HEPa/EtOAc (125 and 250 mg/kg/day) and pioglitazone (5 mg/kg/day), for 16 days. After the treatment, HEPa/EtOAc reduced fasting serum glucose and insulin levels, as well as homeostasis model assessment for insulin resistance. In addition, an improvement in glucose intolerance was also observed. Indeed, a reduction in the circulating levels of TNF-α and IL-6 was also observed. Furthermore, at molecular level, it was demonstrated that the HEPa/EtOAc treatment was able to improve these physiological parameters, through the activation of peroxisome proliferator-activated receptor γ (PPARγ) per si, as well as the enhancement of antioxidant mechanism by an increase in PPARγ/Cu(2+), Zn(2+)-superoxide dismutase (CuZn-SOD) axis expression in liver and adipose tissue. In sum, P. aculeata is effective to improve insulin resistance in a mouse model of obesity and this effect seems to involve the antioxidant and anti-inflammatory mechanisms through the increase in PPARγ/CuZn-SOD axis expression.

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Section: Preparation Of Plant Extractmentioning

confidence: 99%

Section: Data Presented By the World Health Organization (Who)mentioning

confidence: 99%

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Treatment with Parkinsonia aculeata combats insulin resistance-induced oxidative stress through the increase in PPARγ/CuZn-SOD axis expression in diet-induced obesity mice

et al. 2016

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“…It have been reported that herbal remedies may have recognizable therapeutic effects [1]. However, some species of plants have been reported to have hypoglycemic effects; hence, attention has been given to find biologically active compounds from various medicinal plants as a source of natural antidiabetic drugs [2,3,4]. However, only few of these plant have been reported Petersianthus macrocarpus belongs to the family Lecythidaceae.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Evaluation and Anti-Diabetic Effects of Ethanolic Leaf Extract of Petersianthus macrocarpus on Streptozotocin-Induced Diabetic Rats

Ugochukwu

Anna

2021

JAMMR

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Aim: The purpose of this study was to evaluate the antidiabetic effect of ethanolic extracts of Petersianthus macrocarpus leaf and its phytochemical analysis using different solvents. Place and Duration of Study: The study was carried out between March and September in 2018 in the Department of Anatomy, Madonna University, Elele. River State, Nigeria. Materials and Methods: Twenty five Wistar rats, weighing between 200-225g were divided into five groups of five rats. Group A (Control) while Groups B, C, D and E were induced with diabetes using streptozotocin firstly 35mg/kg b.w; and 2 weeks later 25mg/kg b.w. Group B (Diabetic control), Group C received 0.5mg/kg b.w of Glibenclamide. Groups D and E received daily 50 and 100 mg/kg b.w of ethanolic leaf extract of P. macrocarpus orally for two weeks. The fasting blood glucose levels were determined weekly for two weeks. At the end of the experiment, the animals were sacrificed and the pancreas was removed for histological procedures. Results: The body weights increased significantly (P<0.05) in 100 mg/kg b.w group when compared to the diabetic control rats weight at the end of the experiment. Also there was a significantly decreased (P<0.05) in blood glucose levels in P. macrocarpus (100mg/kg b.w). The histological section of the pancreas of diabetic control showed eosinophilic material in the islet, shrinkage of the islet of Langerhans while the group treated with 100 mg/kg of extract showed granulated and well prominent pancreatic islet of Langerhans. Phytochemical screening showed methanolic extract of P. macrocarpus leaf having alkaloid, saponin, tannin, phenol, flavonoid, cardiac glycoside, steroids, terpenoids, anthocyanin and anthraquinone. However, cardiac glycosides and steroids were absent in ethanolic extract. Cardiac glycoside and terpenoids were also absent in hexane and acetone extract, while phenol, cardiac glycosides, steroids and anthrocyanin were absent in the water extract. Conclusion: Ethanolic leaf extract of P. macrocarpus ameliorate streptozotocin-induced diabetes in Wistar rats.

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“…Though different types of oral hypoglycemic agents are available for the treatment of diabetes mellitus, there is increasing demand by patients to use antidiabetic natural products because of the undesirable side effects of the existing drugs. In many countries, much attention has been paid to find novel type of natural antidiabetic drugs from various medicinal plants [ 2 – 5 ]. With thousands of years of medical practice, a great deal of valuable experience has been accumulated in traditional Chinese medical system for diabetic therapy and several herbs have been used to improve the hyperglycemic condition in diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and Hypolipidemic Effects of Ethanolic Extract ofMirabilis jalapaL. Root on Normal and Diabetic Mice

Zhou

Zeng

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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The present study investigated the insulin sensitivity, hypoglycemic, and hypolipidemic activities of ethanolic extract of Mirabilis jalapa L. root (EEM) in normal and diabetic mice. After induction of diabetes with streptozotocin, both normal and diabetic mice were singly or repeatedly for 28 days administrated with EEM at doses of 2, 4, 8 g/kg, respectively. Before induction of diabetes, mice were administrated with EEM at doses of 2, 4, 8 g/kg for 14 days and were injected with streptozotocin and continued on EEM administration for another 28 days. Both after and before induction of diabetes, repeated administration with 4, 8 g/kg EEM continually lowered blood glucose level, decreased serum insulin level and improved insulin sensitivity index, and lowered serum total cholesterol, triglyceride levels and triglyceride content in liver and skeletal muscle, and increased glycogen content in these tissues; but repeated administration had no influence on those indexes of normal mice. Single administration with EEM (4, 8 g/kg) showed hypoglycemic effect in oral glucose tolerance test in normal and diabetic mice. Single administration with EEM had no hypoglycemic and hypolipidemic effects on normal and diabetic mice. These results suggest that EEM possesses both potential insulin sensitivity, hypoglycemic, and hypolipidemic effects on diabetes.

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Characterization of the Antidiabetic Role of Parkinsonia aculeata (Caesalpineaceae)

Cited by 21 publications

References 52 publications

Treatment with Parkinsonia aculeata combats insulin resistance-induced oxidative stress through the increase in PPARγ/CuZn-SOD axis expression in diet-induced obesity mice

Treatment with Parkinsonia aculeata combats insulin resistance-induced oxidative stress through the increase in PPARγ/CuZn-SOD axis expression in diet-induced obesity mice

Phytochemical Evaluation and Anti-Diabetic Effects of Ethanolic Leaf Extract of Petersianthus macrocarpus on Streptozotocin-Induced Diabetic Rats

Hypoglycemic and Hypolipidemic Effects of Ethanolic Extract ofMirabilis jalapaL. Root on Normal and Diabetic Mice

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