Hypoglycemic and Hypolipidemic Effects of Ethanolic Extract ofMirabilis jalapaL. Root on Normal and Diabetic Mice

Abstract

The present study investigated the insulin sensitivity, hypoglycemic, and hypolipidemic activities of ethanolic extract of Mirabilis jalapa L. root (EEM) in normal and diabetic mice. After induction of diabetes with streptozotocin, both normal and diabetic mice were singly or repeatedly for 28 days administrated with EEM at doses of 2, 4, 8 g/kg, respectively. Before induction of diabetes, mice were administrated with EEM at doses of 2, 4, 8 g/kg for 14 days and were injected with streptozotocin and continued on EEM administration for another 28 days. Both after and before induction of diabetes, repeated administration with 4, 8 g/kg EEM continually lowered blood glucose level, decreased serum insulin level and improved insulin sensitivity index, and lowered serum total cholesterol, triglyceride levels and triglyceride content in liver and skeletal muscle, and increased glycogen content in these tissues; but repeated administration had no influence on those indexes of normal mice. Single administration with EEM (4, 8 g/kg) showed hypoglycemic effect in oral glucose tolerance test in normal and diabetic mice. Single administration with EEM had no hypoglycemic and hypolipidemic effects on normal and diabetic mice. These results suggest that EEM possesses both potential insulin sensitivity, hypoglycemic, and hypolipidemic effects on diabetes.

Assessing of Antidiabetic and Ameliorative Effect of<i> </i>Lupin Seed Aqueous Extract on Hyperglycemia, Hyperlipidemia and Effect on pdx1, Nkx6.1, Insulin-1, GLUT-2 and Glucokinase Genes Expression in Streptozotocin-induced Diabetic Rats

“…Different medicinal plants have been known for their anti-diabetic effects by a diversity of mechanisms by way of enhancing pancreatic β-cells regeneration, enhancing glucose dependent-insulin secretion in diabetic rats and improving insulin sensitivity [43]. A number of anti-diabetic herbs have been used for a long period for treatment of hyperglycemia and hyperlipidemia in different diabetic animal models [44,45,46,47].…”

Antidiabetic andantioxidant properties, and α-amylase and α-glucosidase inhibition effects of triterpene saponins from Piper auritum

“…STZ treated animals were provided a 5% glucose solution overnight to overcome drug induced hypoglycemia. After a 10 day period for development of diabetes, mice with moderate diabetes exhibit persistent glycosuria and hyperglycaemia (blood glucose >250 mg/ dL) were used for experiments (11).…”

Protection of Trigonelline on Experimental Diabetic Peripheral Neuropathy

“…Recently the study in our laboratory showed that trigonelline had a beneficial effect for diabetes through decreasing blood glucose and lipid levels, increasing insulin sensitivity index and insulin content, upregulating antioxidant enzyme activity, and decreasing lipid peroxidation [17]. Trigonelline also is one of the main components of Mirabilis jalapa L. root which possesses both potential insulin sensitivity and hypoglycemic and hypolipidemic effects on diabetes [18]. …”