Characterization of the Blood Microbiota in Korean Females with Rosacea

Yun, Yeojun; Kim, Han Na; Chang, Yoosoo; Lee, Yunho; Ryu, Seungho; Shin, Hocheol; Kim, Won Serk; Kim, Hyung Lae; Nam, Jae Hui

doi:10.1159/000496968

Cited by 11 publications

(14 citation statements)

References 28 publications

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“…Although archaea have previously been identified in whole blood [7,50], we found the high number of Euryarchaeota within the Malian dataset surprising. However, investigation of the archaeal reads confirmed they mapped to several different loci (Supplementary Figure 9), and BLAST searches only returned archaea as best matches.…”

Section: Microbiomes Are Distinct Between Global Populationscontrasting

confidence: 70%

The whole blood microbiome of Indonesians reveals translocated and pathogenic microbiota

Bobowik

Darusallam

Kusuma

et al. 2022

Preprint

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Pathogens found within local environments are a major cause of morbidity and mortality. This is particularly true in Indonesia, where infectious diseases such as malaria or dengue are a significant part of the disease burden within the country. One way to strengthen the control of infectious diseases is through better surveillance, however unequal investment in medical funding throughout Indonesia, particularly in rural areas, has resulted in under-reporting of cases. Here, we use transcriptome data from 117 healthy individuals living on the islands of Mentawai, Sumba, and the Indonesian side of New Guinea Island to explore which pathogens are present within whole blood. We are able to detect a broad range of taxa within RNA-sequencing data generated from whole blood, including bacteria, viruses, archaea, and eukaryotes. Using independent component analysis, we find that two of these pathogens—Flaviviridae and Plasmodium—have the most noticeable effects on expression profiles. We also identify specific genes linked with Plasmodium and Flavivirus abundance and find that both of these infections are most pronounced in the easternmost island within our Indonesian dataset. This study provides a framework for novel applications of RNA-seq as surveillance and a better understanding of environmental contributors affecting gene expression within Indonesia.

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Section: Microbiomes Are Distinct Between Global Populationscontrasting

confidence: 70%

The whole blood microbiome of Indonesians reveals translocated and pathogenic microbiota

Bobowik

Darusallam

Kusuma

et al. 2022

Preprint

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“…Fourteen bacterial genera showed different abundance among patients with rosacea and controls. The Rheinheimera genus differed increasingly between groups, with rosacea patients having a much higher abundance 40 . Recently, Shah et al also discovered two variations (Phylum and Class level) in the blood bacterial DNA composition of patients with chronic kidney disease (CKD) vs. healthy at the phylum level (Proteobacteria: 61% in CKD vs. 54% in healthy), and the class level (Gammaproteobacteria: 45% in CKD vs. 38% in healthy).…”

Section: Blood Microbiota and Diseasementioning

confidence: 99%

“…Additionally, the blood‐associated microbiome has been studied in dermatologic diseases such as hidradenitis suppurativa, 38 psoriasis, 39 and rosacea. 40 According to Faith's phylogenetic alpha diversity study, the blood microbiome of rosacea patients differed somewhat from that of controls. The relative abundance of Fusobacteriaceae and Chromatiaceae families was substantially greater in the blood of patients with rosacea.…”

Section: Blood Microbiota and Diseasementioning

confidence: 99%

Exploring blood microbial communities and their influence on human cardiovascular disease

Khan

Zhou

et al. 2022

Clinical Laboratory Analysis

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Background Cardiovascular disease (CVD) is the single biggest contributor to global mortality. CVD encompasses multiple disorders, including atherosclerosis, hypertension, platelet hyperactivity, stroke, hyperlipidemia, and heart failure. In addition to traditional risk factors, the circulating microbiome or the blood microbiome has been analyzed recently in chronic inflammatory diseases, including CVD in humans. Methods For this review, all relevant original research studies were assessed by searching in electronic databases, including PubMed, Google Scholar, and Web of Science, by using relevant keywords. Results This review demonstrated that elevated markers of systemic bacterial exposure are associated with noncommunicable diseases, including CVD. Studies have shown that the bacterial DNA sequence found in healthy blood belongs mainly to the Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria phyla. In cardiac events, such as stroke, coronary heart disease, and myocardial infarction, the increased proportion of Proteobacteria and Actinobacteria phyla was found. Lipopolysaccharides are a major component of Proteobacteria, which play a key role in the onset of CVD. Moreover, recently, a study reported the lower cholesterol‐degrading bacteria, including Caulobacterales order and Caulobacteraceae family were both considerably reduced in myocardial infarction. Conclusion Proteobacteria and Actinobacteria were shown to be independent markers of the risk of CVD. This finding is evidence for the new concept of the role played by blood microbiota dysbiosis in CVD. However, the association between blood microbiota and CVD is still inconsistent. Thus, more deep investigations are required in future to fully understand the role of the bacteria community in causing and preventing CVD.

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“…At the genus level 14 bacterial taxa had different abundance between the rosacea and healthy patients. The Rheinheimera genus differed increasingly across groups with significantly elevated abundance in rosacea patients [66].…”

Section: Relationship Between Blood Microbiome Composition and Rosaceamentioning

confidence: 99%

“…Only a limited number of studies of blood associated microbiome in dermatologic diseases like hidradenitis suppurativa [64], psoriasis [65] or rosacea [66] have been conducted. Faith's phylogenetic alpha diversity analysis showed a marginally significant difference between the blood microbiome of rosacea vs control patients.…”

Section: Relationship Between Blood Microbiome Composition and Rosaceamentioning

confidence: 99%

Interactions between immune system and the microbiome of skin, blood and gut in pathogenesis of rosacea

Joura

Brunner

Nemes-Nikodém

et al. 2021

AMicr

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The increasingly wide use of next-generation sequencing technologies has revolutionised our knowledge of microbial environments associated with human skin, gastrointestinal tract and blood. The collective set of microorganisms influences metabolic processes, affects immune responses, and so directly or indirectly modulates disease. Rosacea is a skin condition of abnormal inflammation and vascular dysfunction, and its progression is affected by Demodex mites on the skin surface. When looking into the effects influencing development of rosacea, it is not only the skin microbiome change that needs to be considered. Changes in the intestinal microbiome and their circulating metabolites, as well as changes in the blood microbiome also affect the progression of rosacea. Recent research has confirmed the increased presence of bacterial genera like Acidaminococcus and Megasphera in the intestinal microbiome and Rheinheimera and Sphingobium in the blood microbiome of rosacea patients. In this review we discuss our current knowledge of the interactions between the immune system and the skin, gut and blood microbiome, with particular attention to rosacea diagnostic opportunities.

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Characterization of the Blood Microbiota in Korean Females with Rosacea

Cited by 11 publications

References 28 publications

The whole blood microbiome of Indonesians reveals translocated and pathogenic microbiota

The whole blood microbiome of Indonesians reveals translocated and pathogenic microbiota

Exploring blood microbial communities and their influence on human cardiovascular disease

Interactions between immune system and the microbiome of skin, blood and gut in pathogenesis of rosacea

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