Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins

Kidd, Simon

doi:10.1016/0092-8674(92)90596-5

Cited by 218 publications

(198 citation statements)

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“…2C). These 33-amino acid repeats exist in about 20 other known proteins, including two Drosophila proteins Notch (15) and Cactus (16,17). They have been given different names but are here called ankyrin repeats (ANK repeats).…”

Section: Resultsmentioning

confidence: 99%

Shark, a Src homology 2, ankyrin repeat, tyrosine kinase, is expressed on the apical surfaces of ectodermal epithelia.

Fèrrante

Reinke

Stanley

1995

Proc. Natl. Acad. Sci. U.S.A.

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Section: Resultsmentioning

confidence: 99%

Shark, a Src homology 2, ankyrin repeat, tyrosine kinase, is expressed on the apical surfaces of ectodermal epithelia.

Fèrrante

Reinke

Stanley

1995

Proc. Natl. Acad. Sci. U.S.A.

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“…In analogy to the constitutive activation of the Dorsal protein in Drosophila development, we favor the first of the two explanations. In Drosophila early embryonic development, the Dorsal protein is kept cytoplasmic due to interaction with the IKB-a-like inhibitor protein Cactus (Geisler et al, 1992;Kidd, 1992). A genetically well defined signal transduction pathway finally results in breaking down the Dorsal-Cactus interaction on the ventral side of the embryo [reviewed in St Johnston and Nusslein-Vollhard (1992)].…”

Section: Discussionmentioning

confidence: 99%

Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells.

Lernbecher¹,

Kistler²,

Wirth³

1994

The EMBO Journal

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“…The cactus protein is a Drosophila homologue of the mammalian IKB family of cytoplasmic anchor proteins [1,2]. During precellular embryonic development, cactus is present in the cytoplasm as heterotrimeric complexes with the rel/ NFKB transcription factor dorsal [3].…”

Section: Introductionmentioning

confidence: 99%

Casein kinase II phosphorylates Ser⁴⁶⁸ in the PEST domain of the Drosophila IκB homologue cactus

1997

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Cactus protein is a Drosophila homologue of the mammalian ΙκΒ family of cytoplasmic anchor proteins. In unstimulated cells they function to retain rel/NFx:B transcription factors in the cytoplasm but are rapidly degraded in response to signalling. The destruction of cactus or ΙκΒα allows the rel/ NFKB transcription factor to relocalise to the nucleus. Cactus is a phosphoprotein and has in its C-terminus a PEST protein stability domain. In this paper we show that, like mammalian ΙκΒα, the PEST domain of cactus is phosphorylated by casein kinase Π. We have localised the site of modification to a single residue, Ser 468 , and find no evidence for additional phosphorylation sites. The conservation of these sites in mammalian and invertebrate cytoplasmic anchor proteins suggests that phosphorylation by casein kinase Π may play a critical functional role, plausibly in the regulation of constitutive or inducible proteolysis.

show abstract

Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins

Cited by 218 publications

References 50 publications

Shark, a Src homology 2, ankyrin repeat, tyrosine kinase, is expressed on the apical surfaces of ectodermal epithelia.

Shark, a Src homology 2, ankyrin repeat, tyrosine kinase, is expressed on the apical surfaces of ectodermal epithelia.

Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells.

Casein kinase II phosphorylates Ser⁴⁶⁸ in the PEST domain of the Drosophila IκB homologue cactus

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Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins

Cited by 218 publications

References 50 publications

Shark, a Src homology 2, ankyrin repeat, tyrosine kinase, is expressed on the apical surfaces of ectodermal epithelia.

Shark, a Src homology 2, ankyrin repeat, tyrosine kinase, is expressed on the apical surfaces of ectodermal epithelia.

Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells.

Casein kinase II phosphorylates Ser468 in the PEST domain of the Drosophila IκB homologue cactus

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Casein kinase II phosphorylates Ser⁴⁶⁸ in the PEST domain of the Drosophila IκB homologue cactus