Characterization of the human zinc finger nfx‑1‑type containing 1 encoding ZNFX1 gene and its response to 12‑O‑tetradecanoyl‑13‑acetate in HL‑60 cells

Hamada, Hiroshi; Yamamura, Mayu; Ohi, Hiroto; Kobayashi, Yota; Niwa, Kuniyoshi; Oyama, Takahiro; Mano, Yasunari; Tanuma, Sei–ichi; Uchiumi, Fumiaki

doi:10.3892/ijo.2019.4860

Cited by 3 publications

(3 citation statements)

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“…7 ZNFX1 expression is low in uninfected cells but is rapidly upregulated in response to viral infections and exposure to type I interferons. 8 ZNFX1 binds to viral RNA and interacts with the mitochondrial antiviral signaling (MAVS) protein, promoting the expression of interferon-stimulated genes (ISGs). Signaling downstream of ZNFX1 does not depend on 2 other MAVS-associated cytosolic viral sensors (retinoic acidinducible gene I [RIG-I] and melanoma differentiationassociated protein 5 [MDA5]).…”

mentioning

confidence: 99%

Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency

Vavassori

Chou

Faletti

et al. 2021

Journal of Allergy and Clinical Immunology

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mentioning

confidence: 99%

Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency

Vavassori

Chou

Faletti

et al. 2021

Journal of Allergy and Clinical Immunology

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“…In addition, RELB is required for TNF-induced differentiation of bone marrow cells into M1 macrophages in mice ( 33 ). Our previous studies indicated that the duplicated GGAA-motif is responsible for the activation of the E2F4 and ZNFX1 genes during TPA-induced macrophage-like differentiation of HL-60 cells ( 34 , 35 ). In HeLa S3 cells, the Sp1/PU.1 ratio is notably increased following the Rsv treatment ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Induction of the human CDC45 gene promoter activity by natural compound trans‑resveratrol

Arakawa,

Kondoh,

Matsushita

et al. 2024

Mol Med Rep

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GGAA motifs in the human TP53 and HELB gene promoters play a part in responding to trans -resveratrol (Rsv) in HeLa S3 cells. This sequence is also present in the 5′-upstream region of the human CDC45 gene, which encodes a component of CMG DNA helicase protein complex. The cells were treated with Rsv (20 µM), then transcripts and the translated protein were analyzed by quantitative RT-PCR and western blotting, respectively. The results showed that the CDC45 gene and protein expression levels were induced after the treatment. To examine whether they were due to the activation of transcription, a 5′-upstream 556-bp of the CDC45 gene was cloned and inserted into a multi-cloning site of the Luciferase (Luc) expression vector. In the present study, various deletion/point mutation-introduced Luc expression plasmids were constructed and they were used for the transient transfection assay. The results showed that the GGAA motif, which is included in a putative RELB protein recognizing sequence, plays a part in the promoter activity with response to Rsv in HeLa S3 cells.

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“…Transcripts with highest module membership in the greenyellow module all represent orthologs to elements of the Interferon (IFN) Mediated response to RNA viruses. Several innate immune mobilized antiviral zinc finger protein orthologs are represented in this module, including PARP12 , ZC3HAVIL , TUT4 , and three orthologs of ZNFX1 , one of which is the hub transcript [ 249 , 252 , 292 , 293 ]. Other transcripts are orthologs of interferon-stimulated genes (ISG) that stimulate or facilitate the expression of other ISG, including ZNFX1 , MRE11 , DTX3L , CMTR1 , and IRF1 [ 222 , 226 , 229 , 244 , 248 ].…”

Section: Discussionmentioning

confidence: 99%

Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica

Kron

Fieber

2021

PLoS ONE

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Aging of the nervous system is typified by depressed metabolism, compromised proteostasis, and increased inflammation that results in cognitive impairment. Differential expression analysis is a popular technique for exploring the molecular underpinnings of neural aging, but technical drawbacks of the methodology often obscure larger expression patterns. Co-expression analysis offers a robust alternative that allows for identification of networks of genes and their putative central regulators. In an effort to expand upon previous work exploring neural aging in the marine model Aplysia californica, we used weighted gene correlation network analysis to identify co-expression networks in a targeted set of aging sensory neurons in these animals. We identified twelve modules, six of which were strongly positively or negatively associated with aging. Kyoto Encyclopedia of Genes analysis and investigation of central module transcripts identified signatures of metabolic impairment, increased reactive oxygen species, compromised proteostasis, disrupted signaling, and increased inflammation. Although modules with immune character were identified, there was no correlation between genes in Aplysia that increased in expression with aging and the orthologous genes in oyster displaying long-term increases in expression after a virus-like challenge. This suggests anti-viral response is not a driver of Aplysia sensory neuron aging.

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Characterization of the human zinc finger nfx‑1‑type containing 1 encoding ZNFX1 gene and its response to 12‑O‑tetradecanoyl‑13‑acetate in HL‑60 cells

Cited by 3 publications

References 51 publications

Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency

Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency

Induction of the human CDC45 gene promoter activity by natural compound trans‑resveratrol

Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica

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