Characterization of the neutron flux during production of 18F at a medical cyclotron and evaluation of the incidental neutron spectrum for neutron damage studies

Jeffries, Bradley D.; Algiere, Christopher; Gallagher, Jake; Nichols, T. A.; So, Joshua R.; Littlefield, Charles W.; Quinn, Michael; Brockman, John D.

doi:10.1016/j.apradiso.2019.108892

Cited by 17 publications

(15 citation statements)

References 21 publications

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“…al . have reported the neutron flux generated from a GE PETtrace-800 employing BTI Targetry high yield 18 F targets TS-1700 (80 μ A) and TS-1650P (72 μ A) [ 14 ]. Measurements were performed using a variety of activation flux wires with different neutron threshold energies along with comparative modelling via STAYS PNNL, MCNP6, and 3-Group programs.…”

Section: Resultsmentioning

confidence: 99%

Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron

Johnstone¹,

Mayordomo

Mausolf³

2023

EPJ Techn Instrum

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New modes of production and supply of short-lived radioisotopes using accelerators are becoming attractive alternatives to the use of nuclear reactors. In this study, the use of a compact accelerator neutron source (CANS) was implemented to explore the production of 99mTc and 101Tc. Irradiations were performed with neutrons generated from a 16.5 MeV cyclotron utilising the 18O(p, n)18F reaction during routine 18F-fluorodeoxyglucose (FDG) production in a commercial radiopharmacy. Natural molybdenum targets in metal form were employed for the production of several Tc isotopes interest via (n, γ) reactions on 98Mo and 100Mo. The production of 99mTc and 101Tc under these conditions is considered and discussed.

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Section: Resultsmentioning

confidence: 99%

Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron

Johnstone¹,

Mayordomo

Mausolf³

2023

EPJ Techn Instrum

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“…Along this line, a considerable scientific effort has been done in the last years in order to characterize secondary neutrons produced at accelerators for the production of nuclear medicine radioisotopes 4 – 9 . In addition, Jeffries et al characterized the neutron fluence rate during a production of 18 F at a medical cyclotron for evaluating its potential use in neutron damage studies 10 . The neutron-induced damage on materials and electronics is a hot topic for space and avionics, as well as for detectors used in medical and High Energy Physics (HEP) applications 11 – 17 .…”

Section: Introductionmentioning

confidence: 99%

A novel experimental approach to characterize neutron fields at high- and low-energy particle accelerators

Braccini

Casolaro

Dellepiane

et al. 2022

Sci Rep

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The characterization of particle accelerator induced neutron fields is challenging but fundamental for research and industrial activities, including radiation protection, neutron metrology, developments of neutron detectors for nuclear and high-energy physics, decommissioning of nuclear facilities, and studies of neutron damage on materials and electronic components. This work reports on the study of a novel approach to the experimental characterization of neutron spectra at two complex accelerator environments, namely the CERF, a high-energy mixed reference field at CERN in Geneva, and the Bern medical cyclotron laboratory, a facility used for multi-disciplinary research activities, and for commercial radioisotope production for nuclear medicine. Measurements were performed through an innovative active neutron spectrometer called DIAMON, a device developed to provide in real time neutron energy spectra without the need of guess distributions. The intercomparison of DIAMON measurements with reference data, Monte Carlo simulations, and with the well-established neutron monitor Berthold LB 6411, has been found to be highly satisfactory in all conditions. It was demonstrated that DIAMON is an almost unique device able to characterize neutron fields induced by hadrons at 120 GeV/c as well as by protons at 18 MeV colliding with different materials. The accurate measurement of neutron spectra at medical cyclotrons during routine radionuclide production for nuclear medicine applications is of paramount importance for the facility decommissioning. The findings of this work are the basis for establishing a methodology for producing controlled proton-induced neutron beams with medical cyclotrons.

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“…Along this line, a considerable scientific effort has been done in the last years in order to characterize secondary neutrons produced at accelerators for the production of nuclear medicine radioisotopes [4][5][6][7][8][9] . In addition, Jeffries et al characterized the neutron fluence rate during a production of 18 F at a medical cyclotron for evaluating its potential use in neutron damage studies 10 . The neutron-induced damage on materials and electronics is a hot topic for space and avionics, as well as for detectors used in medical and High Energy Physics (HEP) applications [11][12][13][14][15][16][17] .…”

Section: Introductionmentioning

confidence: 99%

Neutron fields at high- and low-energy particle accelerators: a novel experimental approach based on the DIAMON spectrometer

Braccini

Casolaro

Dellepiane

et al. 2022

Preprint

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The characterization of particle accelerator induced neutron fields is challenging but fundamental for research and industrial activities, including radiation protection, neutron metrology, developments of neutron detectors for nuclear and high-energy physics, decommissioning of nuclear facilities, and studies of neutron damage on materials and electronic components. This work reports on the study of a novel approach to the experimental characterization of neutron spectra at two complex accelerator environments, namely the CERF, a high-energy mixed reference field at CERN in Geneva, and the Bern medical cyclotron laboratory, a facility used for multi-disciplinary research activities, and for commercial radioisotope production for nuclear medicine. In particular, measurements were performed through an innovative active neutron spectrometer called DIAMON, a device developed to provide in real time neutron energy spectra without the need of guess distributions. The intercomparison of DIAMON measurements with reference data, Monte Carlo simulations, and with the well-established neutron monitor Berthold LB 6411, has been found to be highly satisfactory in all conditions. It was demonstrated that DIAMON is an almost unique device able to characterize neutron fields induced by hadrons at 120 GeV/c as well as by protons at 18 MeV colliding with different materials. The accurate measurement of neutron spectra at medical cyclotrons during routine radionuclides production for nuclear medicine applications is of paramount importance for the facility decommissioning. The findings of this work are the basis for establishing a methodology for producing controlled proton-induced neutron beams with medical cyclotrons.

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Characterization of the neutron flux during production of 18F at a medical cyclotron and evaluation of the incidental neutron spectrum for neutron damage studies

Cited by 17 publications

References 21 publications

Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron

Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron

A novel experimental approach to characterize neutron fields at high- and low-energy particle accelerators

Neutron fields at high- and low-energy particle accelerators: a novel experimental approach based on the DIAMON spectrometer

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