Characterization of the oral and faecal microbiota associated with atopic dermatitis in dogs selected from a purebred Shiba Inu colony

Uchiyama, Jumpei; Osumi, Takafumi; Mizukami, Keijiro; Fukuyama, Tomoki; Shima, Ayaka; Unno, Asaka; Takemura‐Uchiyama, Iyo; Une, Yumi; Murakami, Hironobu; Sakaguchi, Masahiro

doi:10.1111/lam.13828

Cited by 9 publications

(18 citation statements)

References 56 publications

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“…Multiple studies have demonstrated that both dogs and humans with AD suffer from cutaneous dysbiosis. 1,[27][28][29][30][31][32][33][34] Whether the dysbiosis is a cause or a consequence of the atopic state remains unclear. However, a recent birth cohort study sampling 109 puppies and 34 parent dogs from Switzerland showed that although the development of skin microbiota (bacterial and fungal) is influenced by both age and environmental factors (e.g.…”

Section: Updates On Cutaneous Microbiomementioning

confidence: 99%

Update on the skin barrier, cutaneous microbiome and host defence peptides in canine atopic dermatitis

Santoro,

Saridomichelakis,

Eisenschenk

et al. 2023

Veterinary Dermatology

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BackgroundCanine atopic dermatitis (AD) is a complex inflammatory skin disease associated with cutaneous microbiome, immunological and skin barrier alterations. This review summarises the current evidence on skin barrier defects and on cutaneous microbiome dysfunction in canine AD.ObjectiveTo this aim, online citation databases, abstracts and proceedings from international meetings on skin barrier and cutaneous microbiome published between 2015 and 2023 were reviewed.ResultsSince the last update on the pathogenesis of canine AD, published by the International Committee on Allergic Diseases of Animals in 2015, 49 articles have been published on skin barrier function, cutaneous/aural innate immunity and the cutaneous/aural microbiome in atopic dogs. Skin barrier dysfunction and cutaneous microbial dysbiosis are essential players in the pathogenesis of canine AD. It is still unclear if such alterations are primary or secondary to cutaneous inflammation, although some evidence supports their primary involvement in the pathogenesis of canine AD.Conclusion and Clinical RelevanceAlthough many studies have been published since 2015, the understanding of the cutaneous host–microbe interaction is still unclear, as is the role that cutaneous dysbiosis plays in the development and/or worsening of canine AD. More studies are needed aiming to design new therapeutic approaches to restore the skin barrier, to increase and optimise the cutaneous natural defences, and to rebalance the cutaneous microbiome.

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Section: Updates On Cutaneous Microbiomementioning

confidence: 99%

Update on the skin barrier, cutaneous microbiome and host defence peptides in canine atopic dermatitis

Santoro,

Saridomichelakis,

Eisenschenk

et al. 2023

Veterinary Dermatology

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“…Some allergy-associated gut microbial signatures have been identified in humans, either preceding the disease [49,50] or after the onset of the disease [51][52][53]. Information on how and which gut microbes are associated with allergy or atopy (AD) in dogs is scarce and from small samples [25,26].…”

Section: Discussionmentioning

confidence: 99%

“…Concurrently, allergy prevalence among dogs seems to be increasing [ 24 ]. The differences in the gut microbiota between atopic and healthy dogs are not widely studied [ 25 , 26 ], in particular considering the concurrent effect of diet. Similarly to humans [ 27 ], diet plays a dominant role in affecting gut microbial compositions also in pet dogs [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Distinct healthy and atopic canine gut microbiota is influenced by diet and antibiotics

et al. 2023

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The rising trend in non-communicable chronic inflammatory diseases coincides with changes in Western lifestyle. While changes in the human microbiota may play a central role in the development of chronic diseases, estimating the contribution of associated lifestyle factors remains challenging. We studied the influence of lifestyle—diet, antibiotic use, and residential environment with housing and family—on the gut microbiota of healthy and owner-reported atopic pet dogs, searching for associations between the lifestyle factors, atopy and microbiota. The results showed that atopic and healthy dogs had contrasting gut microbial composition. The gut microbiota also differed between two breeds, Labrador Retriever and Finnish Lapphund, selected for our study. Among all lifestyle factors studied, diet was most significantly associated with gut microbiota but only weakly with atopic symptoms. Thus, diet- and atopy-associated changes in the microbiota were not interrelated. Instead, the severity of symptoms was positively associated with the usage of antibiotics, which in turn was associated with the microbiota composition. Urban lifestyle was significantly associated with the increased prevalence of allergies but not with the gut microbiota. Our results from pet dogs supported previous evidence from humans, demonstrating that antibiotics, gut microbiota and atopic manifestation are interrelated. This congruence suggests that canine atopy might be a promising model for understanding the aetiology of human allergy.

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“…For example, altered microbiome pro les are observed in dogs with chronic or acute gastrointestinal diseases [2][3][4] , and symptoms are improved with treatments targeting the gut microbiome, such as probiotics or fecal microbiota transplant [5][6][7][8] . Dogs with chronic diseases such as obesity [9][10][11] , diabetes mellitus 12 , atopic dermatitis 13,14 , poor cognition 15 , and behavioral issues are also found to have different gut microbiome pro les from their healthy counterparts 16,17 , although specialized diets prescribed for these conditions may partially explain such differences. Since diet has a direct impact on the gut microbiome and is a modi able factor that dogs are exposed to on a daily basis, a large amount of effort has been made to identify the relationships between diet and the gut microbiome 1,18 .…”

Section: Introductionmentioning

confidence: 99%

Beagle dogs living in household or controlled environments show different gut microbiome profiles when fed an identical diet or diet type

Tanprasertsuk¹,

Jones²,

Tate³

et al. 2023

Preprint

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Most canine microbiome trials are conducted in a controlled environment, with an unverified assumption that identical findings can be extrapolated to household dogs. In this study, the fecal microbiome of healthy beagles living in household or controlled environments was characterized with shotgun metagenomic sequencing and compared. Beagles were recruited from U.S. households (Pet, n = 54), a private kennel (Kennel, n = 39), and the University of Illinois at Urbana-Champaign (UIUC, n = 34). Dogs were fed an identical diet (fresh chicken, non-extruded and cooked) or diet type (kibble, various brands) for ≥ 7 days. Shannon diversity index was significantly higher in Kennel than Pet when fed both fresh and kibble, and significantly higher than UIUC when fed fresh only. β-Diversity was significantly different among the three cohorts on both diets. Mainly, species belonging to Actinobacteriota, Bacteroidota, Firmicutes_A, Firmicutes, and Proteobacteria were differentially abundant among the cohorts. Likewise, significant discriminant features in the functional data were observed among the cohorts after controlling for diet type. The findings demonstrate the living environment as an important factor in microbial composition, and further draw attention to possible limitations in the translation of findings between dogs in controlled versus free-living environments.

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Characterization of the oral and faecal microbiota associated with atopic dermatitis in dogs selected from a purebred Shiba Inu colony

Cited by 9 publications

References 56 publications

Update on the skin barrier, cutaneous microbiome and host defence peptides in canine atopic dermatitis

Update on the skin barrier, cutaneous microbiome and host defence peptides in canine atopic dermatitis

Distinct healthy and atopic canine gut microbiota is influenced by diet and antibiotics

Beagle dogs living in household or controlled environments show different gut microbiome profiles when fed an identical diet or diet type

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