Characterization of the retention behavior of organic and pharmaceutical drug molecules on an immobilized artificial membrane column with the Abraham model

Comparison of the factors that contribute to retention on immobilized polysaccharide-based chiral stationary phases and macrocyclic glycopeptide chiral stationary phases with the Abraham model☆

“…The probe solutes are listed in Table 2 with their solute descriptors, which were obtained from Refs. [26,37].…”

Linear Solvation Energy Relationships in the Determination of Specificity and Selectivity of Stationary Phases

“…It was also applied for the investigation of retention behavior of drugs and many other biologically important compounds [14–17]. LSER model is therefore very useful when new stationary phases are tested for the analysis of various substances.…”

Linear Free Energy Relationship Analysis of Retention Factors in Cerasome Electrokinetic Chromatography Intended for Predicting Drug Skin Permeation

“…To compare different partitioning systems (including biological and artificial ones) and unravel the structural determinants governing the partitioning of solutes in these systems, we use the Abraham linear free energy relationship (LFER)11–13: where E , S , A , B , and V are solute descriptors. E is the excess molar refraction in (cm 3 mol −1 )/10, S is the solute dipolarity/polarizability, A and B are the overall solute hydrogen bond acidity and hydrogen bond basicity, and V is the McGowan characteristic volume of the solute in (cm 3 mol −1 )/100.…”

“…SP represents a set of solute properties in a given system, for example, SP could be the n ‐octanol–water distribution coefficient log D oct , the skin permeability log K p , or the retention factor log k in LEKC for a series of solutes. Equation 1 has been successfully tested in a wide range of systems, including a large number of partitions from water to organic solvent,12,14,15 various artificial membrane models,9,13,16 as well as biological processes 17–19. The coefficients in Eq.…”

“…In the present study, all the measurements were performed at pH 7.4, where some of the solutes summarized in Table 1 are present as ionic species: cations from protonated amines and anions from deprotonated carboxylic acids. Equation 1 was set up for neutral solutes only12–19 and to extend it to ionic species Abraham and Acree20–23 developed Eq. 2.…”