Characterization of the vaginal and endometrial microbiome in patients with chronic endometritis

Lozano, F M; Bernabéu, A; Lledó, Belén; Morales, Ruth; Díaz, M Baeza; Aranda, F.I.; Llácer, J.; Bernabéu, Rafael

doi:10.1016/j.ejogrb.2021.05.045

Cited by 49 publications

(29 citation statements)

References 24 publications

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“…Several factors may be involved in CE-related impaired reproductive failure [ 14 ]. The disease is primarily caused by abnormal intrauterine bacterial proliferation, as demonstrated by microbiological studies [ 1 , 35 , 36 ], and further confirmed by a high rate of CE cure after antibiotic therapy [ 26 , 37 ]. Intrauterine infection leads to a specific cytokine and leukocyte pattern in order to prepare the uterus to fight the noxa [ 13 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Chronic Endometritis in Infertile Women: Impact of Untreated Disease, Plasma Cell Count and Antibiotic Therapy on IVF Outcome—A Systematic Review and Meta-Analysis

et al. 2022

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This systematic review and meta-analysis aims to evaluate the impact of chronic endometritis (CE) and its therapy on in vitro fertilization (IVF) outcome. Additionally, we aim to investigate whether various degrees of CE severity may exert a different effect on IVF outcome. Ongoing-pregnancy rate/live-birth-rate (OPR/LBR), clinical-pregnancy rate (CPR), and miscarriage rate (MR) were calculated. A total number of 4145 patients (from ten studies) were included. Women with CE had lower OPR/LBR (OR 1.97, p = 0.02) and CPR (OR 2.28, p = 0.002) compared to those without CE. CE cure increased OPR/LBR (OR 5.33, p < 0.0001) and CPR (OR 3.64, p = 0.0001). IVF outcome was comparable between women with cured CE and those without CE (OPR/LBR, CPR and MR: p = ns). Women with severe CE had lower OPR/LBR (OR 0.43, p = 0.003) and CPR (OR 0.40, p = 0.0007) compared to those mild CE. Mild CE showed no influence on the IVF outcome as compared to women without CE (OPR/LBR, CPR and MR: p = ns). Based on this data analysis, CE significantly reduces OPR/LBR and CPR in women undergoing IVF. Importantly, CE resolution after antibiotic therapy may improves IVF outcome, leading to similar OPR/LBR and CPR as compared to unaffected patients. The negative effects of CE on IVF outcome may be restricted to severe disease, whereas mild CE may have no influence on IVF success.

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Section: Discussionmentioning

confidence: 99%

Chronic Endometritis in Infertile Women: Impact of Untreated Disease, Plasma Cell Count and Antibiotic Therapy on IVF Outcome—A Systematic Review and Meta-Analysis

et al. 2022

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“…Consistent with previous findings, Anaerobacillus spp. was also found to have a distinctly higher abundance in endometrial tissue that was CD138 positive ( 23 ). Since the proportion rate of chronic endometritis in the RSA group was significantly higher than that in the control group, an increased abundance of Anaerobacillus spp.…”

Section: Discussionmentioning

confidence: 99%

An Altered Microbiota in the Lower and Upper Female Reproductive Tract of Women with Recurrent Spontaneous Abortion

Liu

Yang

et al. 2022

Microbiol Spectr

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“…and Gardnerella spp. were associated with CE [ 69 ]; and higher numbers of Phyllobacterium and Sphingomonas are also reported in CE patients [ 70 ]. Comparison of the intrauterine microbiome of 20 patients with polyps and CE and 10 healthy individuals identified higher proportions of bacteria such as Bifidobacterium , Gardnerella, Lactobacillus , and Streptococcus in the patient group and higher numbers of Pseudomonas in the healthy control group [ 71 ].…”

Section: Microbiota Alterations In Infertilitymentioning

confidence: 99%

The Endometrial Microbiome and Its Impact on Human Conception

Toson¹,

Simón

Moreno-Gimeno

2022

IJMS

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Changes in the female genital tract microbiome are consistently correlated to gynecological and obstetrical pathologies, and tract dysbiosis can impact reproductive outcomes during fertility treatment. Nonetheless, a consensus regarding the physiological microbiome core inside the uterine cavity has not been reached due to a myriad of study limitations, such as sample size and experimental design variations, and the influence of endometrial bacterial communities on human reproduction remains debated. Understanding the healthy endometrial microbiota and how changes in its composition affect fertility would potentially allow personalized treatment through microbiome management during assisted reproductive therapies, ultimately leading to improvement of clinical outcomes. Here, we review current knowledge regarding the uterine microbiota and how it relates to human conception.

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Characterization of the vaginal and endometrial microbiome in patients with chronic endometritis

Cited by 49 publications

References 24 publications

Chronic Endometritis in Infertile Women: Impact of Untreated Disease, Plasma Cell Count and Antibiotic Therapy on IVF Outcome—A Systematic Review and Meta-Analysis

Chronic Endometritis in Infertile Women: Impact of Untreated Disease, Plasma Cell Count and Antibiotic Therapy on IVF Outcome—A Systematic Review and Meta-Analysis

An Altered Microbiota in the Lower and Upper Female Reproductive Tract of Women with Recurrent Spontaneous Abortion

The Endometrial Microbiome and Its Impact on Human Conception

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