Characterization of three co-circulating genotypes of the small hydrophobic protein gene of mumps virus.

Tecle, Tesfaldet; Johansson, Bo; Jejcic, Alenka; Forsgren, Marianne; Örvell, Claes

doi:10.1099/0022-1317-79-12-2929

Cited by 38 publications

(50 citation statements)

References 33 publications

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“…Several epidemiological studies reported that some genotypes (C, D, H, I, or J) were able to cause central nervous system (CNS) diseases (20,28,(34)(35)(36)38). Mongolian MuVs belong to genotype H, and all originated from the hospitalized mumps patients.…”

Section: Mumps Epidemics In Mongoliamentioning

confidence: 99%

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Characterization of Mumps Viruses Circulating in Mongolia: Identification of a Novel Cluster of Genotype H

et al. 2011

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Although mumps virus is still causing annual epidemics in Mongolia, very few epidemiological and virological data have been reported. We describe here the first phylogenetic analysis data on the mumps viruses circulated in Mongolia in 2009. We detected 21 mumps virus cDNAs and obtained a virus isolate from 32 throat swabs of mumps patients in Ulaanbaatar, the capital of Mongolia. The phylogenetic analyses based on the 316 nucleotides of the small hydrophobic gene show that these sequences form a single cluster, with the closest relatedness to the viruses belonging to genotype H. According to the recommendation of the World Health Organization, Mongolian mumps viruses could be classified into a novel genotype because the divergence between new sequences and genotype H reference viruses is >5% (6.3 to 8.2%). However, additional analyses based on the fusion gene, the hemagglutinin-neuraminidase gene, and the whole-genome indicate that the divergences between the Mongolian isolate and other genotype H strains never exceed the within-genotype divergences of other genotypes. These results suggest that Mongolia strains should be included in genotype H and that the current criteria for mumps virus genotyping should be revised. We propose here that the Mongolian viruses should be classified as a new subgenotype termed H3. Since previous epidemiological studies suggested that genotypes H may be associated with central nervous system diseases, we evaluated the neurovirulence of the Mongolian isolate in the neonatal rat system. However, the virus does not exhibit prominent neurovirulence in rats.

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Section: Mumps Epidemics In Mongoliamentioning

confidence: 99%

“…For instance, genotypes A, C, D, E, and H are mainly observed in the Western Hemisphere (1,2,13,34), whereas genotypes B, F, and I are solely detected in Asia (16,28,30,42). Some studies have reported the potential associations between genotypes C, D, H, I, or J and neuropathogenicity (28,35,36,38).…”

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Characterization of Mumps Viruses Circulating in Mongolia: Identification of a Novel Cluster of Genotype H

et al. 2011

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“…Several studies report that a correlation between genetic variation and virulence among MuV strains (2,13,14). A relationship between viral genotype and clinical symptoms was also reported (19). The relevance of MuV genotypes G, H, and K to particular clinical features is still unclear.…”

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Characterization of the F Gene of Contemporary Mumps Virus Strains Isolated in Japan

Uchida¹,

Shinohara²,

Shimada³

et al. 2003

Microbiology and Immunology

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Mumps virus (MuV) strains isolated in Saitama Prefecture, Japan, from 1997 to 2001, were examined by analyzing the SH and the F gene nucleotide sequences. The results of the SH gene analysis showed that only genotype G was found in 2001 as well as in 2000, and that genotype J, which we proposed as a new genotype in a previous study, was from a different lineage than the genotype J described by Tecle et al. (J. Gen. Virol. 82, 2675–2680). We therefore, propose to rename the genotype as K to avoid confusion. Then, the F gene of genotypes G, H, and K strains were analyzed together with previously reported strains in this study. The results of phylogenetic analysis of the F gene nucleotide sequences showed that these strains formed a cluster as described by the SH gene analysis. Alignment of the F amino acid sequences showed that the F protein was well conserved among strains of different genotypes with a few amino acid differences. These results provide better information for the characterization of contemporary MuV strains in Japan.

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“…Finally, previous experience with the elimination programs for other preventable viral diseases, such as measles, rubella, and polio, suggest that genotyping would facilitate mumps surveillance (38), since the pattern of viral circulation can be traced. Consequently, molecular epidemiology studies have been performed around the world (2,7,10,11,12,15,17,18,23,31,32,33,34,35,41).Mumps vaccination was introduced in the Spanish national vaccination repertoire in 1981 as part of the triple viral vaccine (the MMR vaccine). As a result, the number of mumps cases fell from 286,887 in 1984 to 1,527 in 2004.…”

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Circulation of Mumps Virus Genotypes in Spain from 1996 to 2007

et al. 2010

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Mumps is a highly transmissible but usually benign disease consisting of bilateral swelling of the salivary glands. In some instances, though, clinical complications can arise. Bilateral orchitis and clinical self-limited meningitis or more serious complications, such as encephalitis, deafness, male sexual sterility, and pancreatitis, may occur in rare cases (9).Mumps virus (MV), a virus belonging to the genus Rubulavirus of the subfamily Paramyxovirinae, is considered monotypic regarding its antigenicity. Thus, mumps vaccination is part of the regular immunization schedule of many countries, usually along with the measles and rubella vaccination (i.e., the MMR vaccine) in a single formulation. However, in contrast to rubella and measles, secondary vaccine failure frequently allows MV circulation within highly immunized populations (1,5,8,24,36). The use of a poorly immunogenic genotype A strain called Rubini has been proposed as a cause of these major failures, although the occurrence of mumps in patients immunized with other vaccine strains has also been described (26).Genetic variation in the small hydrophobic (SH) gene has led to the characterization of 12 genotypes, which are recognized by the WHO (13, 14, 23). Differential efficiency on cross neutralization among different genotypes has been suggested (20, 21), as have the differential capacities of certain strains to invade the neural system (25, 32). Finally, previous experience with the elimination programs for other preventable viral diseases, such as measles, rubella, and polio, suggest that genotyping would facilitate mumps surveillance (38), since the pattern of viral circulation can be traced. Consequently, molecular epidemiology studies have been performed around the world (2,7,10,11,12,15,17,18,23,31,32,33,34,35,41).Mumps vaccination was introduced in the Spanish national vaccination repertoire in 1981 as part of the triple viral vaccine (the MMR vaccine). As a result, the number of mumps cases fell from 286,887 in 1984 to 1,527 in 2004. However, the general descendant trend was interrupted by some peaks: in 1989 (from 48,393 in 1987 to 83,527 in 1989), 1996 (from 7,002 in 1995 to 14,411 in 1996), 2000 (from 2,857 in 1998 to 9,391 in 2000), and 2007 (from 1,527 in 2004 to 10,219 in 2007). Surprisingly, these peaks occurred despite a national vaccine coverage rate of over 95% of the population by 1999. As has been previously reported (29,30), the occurrence of vaccinated individuals with MV RNA present in their saliva and/or urine with viral IgG but not IgM in acute-phase serum was frequent, suggesting secondary vaccine failure. Although most secondary vaccine failures were associated with the use of at least one dose of the Rubini strain, cases of mumps in patients vaccinated with two doses of the Jerryl Lynn strain were also observed (29,30).In this report, we describe the MV genotypes circulating in Spain over the past 8 years. This represents the first series of data obtained for the national level. Interestingly, this series comprises three...

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Characterization of three co-circulating genotypes of the small hydrophobic protein gene of mumps virus.

Cited by 38 publications

References 33 publications

Characterization of Mumps Viruses Circulating in Mongolia: Identification of a Novel Cluster of Genotype H

Characterization of Mumps Viruses Circulating in Mongolia: Identification of a Novel Cluster of Genotype H

Characterization of the F Gene of Contemporary Mumps Virus Strains Isolated in Japan

Circulation of Mumps Virus Genotypes in Spain from 1996 to 2007

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