Characterization of total retinoid-like activity of compounds produced by three common phytoplankton species

Sychrová, Eliška; Priebojová, Jana; Smutná, Marie; Nováková, Kateřina; Kohoutek, Jiří; Hilscherová, Klára

doi:10.1016/j.hal.2016.11.002

Cited by 11 publications

(4 citation statements)

References 55 publications

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“…Retinoic acid has more recently been identified in cyanobacteria both grown in culture and in blooms isolated in China, where it is thought to be responsible for the mutagenesis of frogs [3][4][5][6][7][8][9] Thus far, no mechanism for cyanobacterial retinoic acid production has been defined, beyond it being a potential degradation product of retinal [10].…”

Section: Introductionmentioning

confidence: 99%

Identification of a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro

Miles

Machattou

Nevin-Jones

et al. 2019

Biochemical and Biophysical Research Communications

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Retinoic acid signalling is generally considered to be of animal origin. Recently, retinoic acid has been identified in cyanobacteria, yet no mechanism for its production has been identified. Here, we characterize for the first time a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro. Our computational studies suggest that the cyanobacterial aldehyde dehydrogenase resembles an ancestor of both eukaryotic aldehyde dehydrogenase 1 and aldehyde dehydrogenase 2. The Chlorogloeopsis fritschii aldehyde dehydrogenase described here may find applications in synthetic production of retinoic acid as well as contributing to our understanding of retinoid synthesis in cyanobacteria.

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Section: Introductionmentioning

confidence: 99%

Identification of a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro

Miles

Machattou

Nevin-Jones

et al. 2019

Biochemical and Biophysical Research Communications

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“…29 The production of retinoids by algae and cyanobacteria was found to be dependent on species, origin, and growth stage 21,27 and could be affected by environmental parameters like light, temperature, and nutrient levels. 26 For example, concentrations of RAs and 4-oxo-RAs in O. nigroviridis (CCAP 1459/9; 31.0 ± 7.3 ng/g dm) were two times higher than those in Spirulina subsalsa (CCAP 1475/1; 12.2 ± 2.1 ng/g dm). In cultured cyanobacteria, 13c-RA and 13c-oxo-RA were the dominant compounds, accounting for 51%−71% of total concentrations, followed by at-RA and at-4oxo-RA with 18%−26% (Figure 1C; Table S4).…”

Section: ■ Results and Discussionmentioning

confidence: 95%

“…It is, therefore, suggested that some RAs and 4-oxo-RAs in surface films originate from cyanobacteria. Relatively large concentrations of retinoids were also detected in freshwater cyanobacteria including Microcystis aeruginosa. ,− A recent study has suggested that RAs can be transformed from retinal by a cyanobacterial aldehyde dehydrogenase (ALDH) that is much evolutionarily closer to its counterpart in animals . The production of retinoids by algae and cyanobacteria was found to be dependent on species, origin, and growth stage , and could be affected by environmental parameters like light, temperature, and nutrient levels .…”

Section: Resultsmentioning

confidence: 99%

Insights into the Influence of Natural Retinoic Acids on Imposex Induction in Female Marine Gastropods in the Coastal Environment

Zhou

et al. 2021

Environ. Sci. Technol. Lett.

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Conventionally, development of imposex, i.e., superimposition of male sexual characteristics on females, in marine neogastropods has been solely linked to exposure to synthetic organotin compounds, such as triphenyltin (TPT), in the marine environment. Here, our experimental results show that marine cyanobacteria can produce retinoic acids (RAs) and their oxidative metabolites 4-oxo-RAs, and the most commonly distributed RA, i.e., all-trans-RA, can also trigger expression of genes related to imposex in female whelks Reishia clavigera after chronic exposure of 60 days. Both estimated concentrations of TPT and RAs and 4-oxo-RAs in seawater are positively associated with the Vas Deferens Sequence Index (VDSI) in female whelks collected from various sites along the coast of Hong Kong; the concentration of TPT explains 28% of the total variation of VDSI, while the total concentrations of RAs and 4-oxo-RAs contributed to 14% of the variation based on separate regression analyses. Our discoveries have implications on the cause and magnitude of imposex in marine neogastropods, calling for more research in ecotoxicology of natural RAs and 4-oxo-RAs in the marine environment in the future.

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“…Phytoplankton. Phytoplankton, which contain valuable phytonutrients and bioactive compounds (1909.1 mg/l of protein, 55.4 mg/L of carbohydrates, and 6.5 mg/L of lipid, and 0.064-0.234 ng/10 6 cells of retinoid-like activity of metabolites), have signifcant implications for hatcheries and larval development [87,88]. Te contents ((%) of total fatty acid) of main fatty acid from the classes Cyanophyceae, Chlorophyceae, Chlorodendrophyceae, Pyramimonadophyceae, Mamiellophiceae, Trebouxiophyceae, Porphyridophyceae, Cryptophyceae, Coccolithophyceae, Pavlovophyceae, Eustigmatophyceae, Raphidophyceae, Pelagophyceae, Dinophyceae, and the phylum Bacillariophyta are shown in Table 4.…”

Section: General Properties Of Natural Biota As Promising Candidates ...mentioning

confidence: 99%

Natural Biota’s Contribution to Cultured Aquatic Animals’ Growth in Aquaculture Cannot Be Ignored

Jin

Kong

John

et al. 2023

Aquaculture Research

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The rapid expansion of the aquaculture industry is accompanied by high organic and nutrient loadings from formulated feeds. This leads to water deterioration and pathogenic microorganisms. Natural biota (e.g., bacteria, phytoplankton, zooplankton, and zoobenthos) in ponds form important parts of cultured aquatic animals’ diets. They contain essential proteins, lipids, carbohydrates, amino acids, and fatty acids and are considered promising supplementary nutrition sources for cultured aquatic animals. Particularly, they are available to aquatic animals throughout the day, and an adequate supply of them as starter foods during the larvae stage ensures high survival. Since formulated feeds constitute more than 50% of aquaculture production costs, optimizing the utilization of natural biota and reducing dietary nutrient input without compromising animals’ growth should be a priority to improve the economic success and sustainability of aquaculture. From this scenario, the present review offers an updated view of the natural biota category in aquaculture systems, their nutritional components, and their contributions to the growth of cultured aquatic animals. Taken together, this review emphasizes the significant roles of natural biota playing in the growth of aquatic animals and encourages maximizing utilization of natural biota to improve feed conversion efficiency and aquaculture sustainability.

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Characterization of total retinoid-like activity of compounds produced by three common phytoplankton species

Cited by 11 publications

References 55 publications

Identification of a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro

Identification of a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro

Insights into the Influence of Natural Retinoic Acids on Imposex Induction in Female Marine Gastropods in the Coastal Environment

Natural Biota’s Contribution to Cultured Aquatic Animals’ Growth in Aquaculture Cannot Be Ignored

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