Characterization of tumour laser ablation probes with temperature measuring capabilities

Abstract

The paper reports on the development and characterization of an innovative all-optical laser delivery fibre probe for cancer cell ablation with simultaneous temperature sensing capabilities. The probe integrates a grating-based temperature sensor and a laser delivery fibre whose tip surface is micro-structured for adapting the beam diffusion to the tumour geometry. Different temperature sensor configurations are analysed; then the most promising is characterized in a simulated laser ablation process using a specific phantom to emulate real liver tissue.

Towards inline spatially resolved temperature sensing in thermal ablation with chirped fiber Bragg grating

“…It is possible to show, in the inset of Fig. 8, that the wavelength shift in the inner part of the CFBG spectrum has an almost exponential growth, as in [4] for a solid-state laser and in [21] for a diode-pumped fiber laser. Such results are highlighted in Fig.…”

“…Glass fibers are also chemically and biologically inert. While the first application of an optical fiber sensor in hyperthermia dates back to 2000 [16], most advances in the application of optical fiber sensing technology in TA have been reported in the last triennium [17][18][19][20][21][22][23].…”

Comparison of surface micro-structured and plasmonic all-fiber delivery probes for laser-induced thermotherapy of tumor cells

“…The probe includes also a FBG sensor to measure the induced temperature, as described in other papers. 8,9 Figure 1. Schematic representation of a laser applicator with micropattened surface to control the irradiation shape and picture of such a probe.…”

Optical fiber flowmeter based on a single mode-multimode-single mode structure

“…The most widespread fiber temperature sensors are based on Fiber Bragg Gratings (FBGs), in which the temperature induces a shift in the grating spectral response. For example, in the biomedical field FBG sensors have been used to monitor the temperature increase during tumor laser ablation (Liu et al, 2015;Vallan et al, 2017). However, FBG sensors, like all other fiber sensors, suffer from a strain-temperature cross-sensitivity for which deformations induced in the sensitive area produce an effect undistinguishable from a temperature variation, though there have been reported investigations on how to mitigate the cross-sensitivity by proper choosing the materials that make the sensor or its package or by combining a plurality of sensors (Leal-Junior et al, 2019).…”