Characterization of two isoforms of antiliopolysacchride factors (Sp-ALFs) from the mud crab Scylla paramamosain

Liu, Haipeng; Chen, Rongyuan; Zhang, Qiuxia; Wang, Qiao-yang; Li, Cong-ru; Peng, Hui; Cai, Ling; Zheng, Chao; Wang, Kejian

doi:10.1016/j.fsi.2012.03.014

Cited by 48 publications

(13 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its isoforms exhibited substantial amino acid sequence homology with other crustacean antilipopolysaccharide factors. Recombinant rSp-ALFs and sSp-ALFs expressed potent activity against white spot syndrome virus in crustaceans (Liu et al 2012a). …”

Section: Antiviral Activity Of Crustacean Productsmentioning

confidence: 99%

Antifungal and antiviral products of marine organisms

Cheung

Wong

Pan

et al. 2014

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Marine organisms including bacteria, fungi, algae, sponges, echinoderms, mollusks, and cephalochordates produce a variety of products with antifungal activity including bacterial chitinases, lipopeptides, and lactones; fungal (−)-sclerotiorin and peptaibols, purpurides B and C, berkedrimane B and purpuride; algal gambieric acids A and B, phlorotannins; 3,5-dibromo-2-(3,5-dibromo-2-methoxyphenoxy)phenol, spongistatin 1, eurysterols A and B, nortetillapyrone, bromotyrosine alkaloids, bis-indole alkaloid, ageloxime B and (−)-ageloxime D, haliscosamine, hamigeran G, hippolachnin A from sponges; echinoderm triterpene glycosides and alkene sulfates; molluscan kahalalide F and a 1485-Da peptide with a sequence SRSELIVHQR; and cepalochordate chitotriosidase and a 5026.9-Da antifungal peptide. The antiviral compounds from marine organisms include bacterial polysaccharide and furan-2-yl acetate; fungal macrolide, purpurester A, purpurquinone B, isoindolone derivatives, alterporriol Q, tetrahydroaltersolanol C and asperterrestide A, algal diterpenes, xylogalactofucan, alginic acid, glycolipid sulfoquinovosyldiacylglycerol, sulfated polysaccharide p-KG03, meroditerpenoids, methyl ester derivative of vatomaric acid, lectins, polysaccharides, tannins, cnidarian zoanthoxanthin alkaloids, norditerpenoid and capilloquinol; crustacean antilipopolysaccharide factors, molluscan hemocyanin; echinoderm triterpenoid glycosides; tunicate didemnin B, tamandarins A and B and; tilapia hepcidin 1–5 (TH 1–5), seabream SauMx1, SauMx2, and SauMx3, and orange-spotted grouper β-defensin. Although the mechanisms of antifungal and antiviral activities of only some of the afore-mentioned compounds have been elucidated, the possibility to use those known to have distinctly different mechanisms, good bioavailability, and minimal toxicity in combination therapy remains to be investigated. It is also worthwhile to test the marine antimicrobials for possible synergism with existing drugs. The prospects of employing them in clinical practice are promising in view of the wealth of these compounds from marine organisms. The compounds may also be used in agriculture and the food industry.

show abstract

Section: Antiviral Activity Of Crustacean Productsmentioning

confidence: 99%

Antifungal and antiviral products of marine organisms

Cheung

Wong

Pan

et al. 2014

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

show abstract

“…Meanwhile, Sc-crustin was composed of 433 base pairs in length and 144 amino acid residues with an estimated molecular weight of 10.24 kDa and pI of 8.76. In relation to this, another AMP known as SpALF3 was identified by Liu's group which further demonstrated that both SpALF1 (former name was ALFSp1) and SpALF3 tend to exhibit strong antibacterial activity [39].…”

Section: Antimicrobial Peptides In Mud Crabsmentioning

confidence: 95%

A Brief Review on the Antioxidants and Antimicrobial Peptides Revealed in Mud Crabs from the Genus of Scylla

Yusof

Ahmad

Swamy

2017

Journal of Marine Biology

View full text Add to dashboard Cite

Mud crab from the genus Scylla is also known as mangrove crab, which has been well-accepted as a good source of protein.Recently, the antioxidant properties present in mud crabs have been reported to have a part in the protection of cells against free radicals. Meanwhile, numerous antimicrobial peptides from mud crabs have managed to be characterized through the display of antimicrobial activities against Gram-positive and Gram-negative bacteria. Hence, this paper is an effort to collect recent literatures on antioxidant and antimicrobial properties in every part of mud crabs which include muscle tissue, hemolymph, and crab shell. Moreover, the effort to understand the biological properties of mud crabs is important to enhance its production in aquaculture industry. Therefore, this review hoped to attract the attention of natural product researchers to focus on the potential therapeutic applications of mud crabs.

show abstract

“…The full-length cDNAs encoding SpALF1 (JQ069030) and SpALF2 (JQ06931) from the mud crab Scylla paramamosain have been produced [41] (Figure 3), and the encoded proteins were expressed in Pichia pastris . Comparative analysis of the recombinant proteins (rSP-ALF1 and rSp-ALF2) indicates the presence of a putative LPS binding loop, and synthetic peptide fragments of the LPS binding domain ((sSP-ALF1 (Acetylated-HTCHFRRRPKVRKFKLYHEGKFWCPG-aminated) and sSp-ALF2 (Acetylated-HTCHIRRRPKFRKFKLYHEGKFWCPG-aminated) as well as the recombinant proteins (rSP-ALF1 and rSp-ALF2), themselves, exhibit strong bactericidal activity against Gram-positive and Gram-negative bacteria [41].…”

Section: Anti-lps Factorsmentioning

confidence: 99%

The Role of Biophysical Parameters in the Antilipopolysaccharide Activities of Antimicrobial Peptides from Marine Fish

2014

View full text Add to dashboard Cite

Numerous antimicrobial peptides (AMPs) from marine fish have been identified, isolated and characterized. These peptides act as host defense molecules that exert antimicrobial effects by targeting the lipopolysaccharide (LPS) of Gram-negative bacteria. The LPS-AMP interactions are driven by the biophysical properties of AMPs. In this review, therefore, we will focus on the physiochemical properties of AMPs; that is, the contributions made by their sequences, net charge, hydrophobicity and amphipathicity to their mechanism of action. Moreover, the interactions between LPS and fish AMPs and the structure of fish AMPs with LPS bound will also be discussed. A better understanding of the biophysical properties will be useful in the design of AMPs effective against septic shock and multidrug-resistant bacterial strains, including those that commonly produce wound infections.

show abstract

Characterization of two isoforms of antiliopolysacchride factors (Sp-ALFs) from the mud crab Scylla paramamosain

Cited by 48 publications

References 44 publications

Antifungal and antiviral products of marine organisms

Antifungal and antiviral products of marine organisms

A Brief Review on the Antioxidants and Antimicrobial Peptides Revealed in Mud Crabs from the Genus of Scylla

The Role of Biophysical Parameters in the Antilipopolysaccharide Activities of Antimicrobial Peptides from Marine Fish

Contact Info

Product

Resources

About