Characterization of virulence factors and antibiotic resistance pattern of uropathogenic Escherichia coli strains in a tertiary care center

M, Naveen Kumar; Bhat, Sevitha; K, Archana Bhat; Saralaya, Vishwas; Mulki, Shalini Shenoy

doi:10.12688/f1000research.125596.2

Cited by 1 publication

(1 citation statement)

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“…Indeed, in addition to the global emergence of resistance to carbapenems, the significant increase in the prevalence of quinolones-resistant E. coli strains has also been reported in several countries limiting the treatment choice for these bacterial infections, thereby constituting a real problem for public health [74,75]. Uropathogenic E. coli (UPEC) is the bacterium mostly involved in 80 to 90% of UTI cases [76,77] and in 40% of hospital acquired UTIs [78]. These strains have become more resistant to antibiotics with the increasing prevalence of extendedspectrum β-lactamases (ESBLs) [74,79].…”

Section: Escherichia Colimentioning

confidence: 99%

Medical Device-Associated Biofilm Infections and Multidrug-Resistant Pathogens

Bouhrour,

Nibbering,

Bendali

2024

Pathogens

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Medical devices such as venous catheters (VCs) and urinary catheters (UCs) are widely used in the hospital setting. However, the implantation of these devices is often accompanied by complications. About 60 to 70% of nosocomial infections (NIs) are linked to biofilms. The main complication is the ability of microorganisms to adhere to surfaces and form biofilms which protect them and help them to persist in the host. Indeed, by crossing the skin barrier, the insertion of VC inevitably allows skin flora or accidental environmental contaminants to access the underlying tissues and cause fatal complications like bloodstream infections (BSIs). In fact, 80,000 central venous catheters—BSIs (CVC-BSIs)—mainly occur in intensive care units (ICUs) with a death rate of 12 to 25%. Similarly, catheter-associated urinary tract infections (CA-UTIs) are the most commonlyhospital-acquired infections (HAIs) worldwide. These infections represent up to 40% of NIs.In this review, we present a summary of biofilm formation steps. We provide an overview of two main and important infections in clinical settings linked to medical devices, namely the catheter-asociated bloodstream infections (CA-BSIs) and catheter-associated urinary tract infections (CA-UTIs), and highlight also the most multidrug resistant bacteria implicated in these infections. Furthermore, we draw attention toseveral useful prevention strategies, and advanced antimicrobial and antifouling approaches developed to reduce bacterial colonization on catheter surfaces and the incidence of the catheter-related infections.

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