Integrating ethnochemistry into the curriculum may provide students meaningful learning in addition to preservation and appreciation towards the quality of their cultural heritage. Hence, the study aimed to document the indigenous usage of household chemicals of Maguindanaons through ethnography research using purposive and snowball sampling in the selected municipalities of Maguindanao Province. Interview, Focus Group Discussion (FGD) and observation were employed for data collection in the five (5)-month community immersion. The data were then thematically analysed. As revealed, they had utilized substitutes for paint, floor polishers, mosquito repellents, bath and laundry soaps, toothpastes, perfumes, shampoo and other cosmetics. Furthermore, the study found out that their indigenous usage of household chemicals conforms to standard chemical bases. Accordingly, the output of the study may serve as groundwork to develop culture-based lessons in high school Chemistry in the said locale.