Characterization of volatile compounds of &lt;i&gt;Albertisia papuana&lt;/i&gt; Becc root extracts and cytotoxic activity in breast cancer cell line T47D

Kristiani, Elizabeth Betty Elok; Nugroho, Laurentius Hartanto; Moeljopawiro, Sukarti; Widyarini, Sitarina

doi:10.4314/tjpr.v15i5.9

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…The spores of the strain of M. anisopliae selected for the current study had shown virulence against various pest species including Ocinara varians Walker [13], Coptotermes formosanus Shiraki [14,15], and O. afrasiaticus (McGregor) [16]. On the other hand, plant secondary metabolite, 1-Chlorooctadecane selected for the current study is a promising pest management candidate known to extract from numerous plant species including Albertisia papuana Becc [17], Syzygium cumini (L.) [18], Arisaema amurense Maxim [19], and fungus, Trichoderma harzianum [20]. 1-Chlorooctadecane (CH 3 (CH 2 ) 16CH 2 Cl) was screened from our preliminary study on the chemical fractionation of Cucumis sativus that showed toxicity against date palm dust mites.…”

Section: Introductionmentioning

confidence: 96%

Potential Synergy between Spores of Metarhizium anisopliae and Plant Secondary Metabolite, 1-Chlorooctadecane for Effective Natural Acaricide Development

Hussain

AlJabr

2020

Molecules

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Date palm dust mites are important pests severely infesting valuable nutritious fruits (dates) of date palm. In search of an alternative to acaricides, joint action of Metarhizium anisopliae EBCL 02049 spores and 1-Chlorooctadecane was evaluated as a potential candidate for the management of Oligonychus afrasiaticus through natural products. In this regard, in vitro tests were performed to evaluate the interaction of M. anisopliae spores with multiple doses of 1-Chlorooctadecane (0.8, 1.6, 2.4, 3.2, and 4.0 mg/mL). Compatibility bioassay results evidenced from vegetative growth (77.7–84.40 mm), sporulation (5.50–7.30 × 106 spores/mL), and germination (96.70–98.20%), revealed that all the tested doses are compatible (biological index > 82) with the spores of M. anisopliae. The impact of combined treatment of spores with 1-Chlorooctadecane in different proportions (Scheme I, II, III, and IV) compared to their sole application against O. afrasiaticus was evaluated by concentration–mortality response bioassays. Results showed that all the combined treatments revealed high mortality compared to the sole application, which showed relatively slow mortality response over time. Toxicity recorded from Scheme IV combinations (80% 1-Chlorooctadecane: 20% Spores), exhibited strong synergistic interaction (joint toxicity = 713). Furthermore, potent interactions have overcome the host antioxidant defense at the final stage of infection by tremendously reducing catalase, and superoxide dismutase activities. These experiments demonstrated fungal–toxin joint synergistic interaction as a promising date palm dust mite management option.

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Section: Introductionmentioning

confidence: 96%

Potential Synergy between Spores of Metarhizium anisopliae and Plant Secondary Metabolite, 1-Chlorooctadecane for Effective Natural Acaricide Development

Hussain

AlJabr

2020

Molecules

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“…Plants are excellent sources of secondary metabolites such as phenolics, flavonoids, alkaloids, lignans, and terpenoids (Karakaya et al, 2019). The various capabilities of secondary metabolites in plants including as sedative (Bahmani et al, 2019), antibacterial (Ibrahim et al, 2013;Kasmiyati et al, 2021) antispasmodic (Martinez-Perez et al, 2018), antidepressant (Eloziia et al, 2017;Rahman et al, 2017), anticancer (Kristiani et al, 2016;Middleton et al, 2000;Kristiani et al, 2021), anti-inflammatory, analgesic, antipyretic, hepatoprotective, and nephritic (Yusufoglu, 2014;Haidara et al, 2020), analgesic, immunomodulatory, and/or antioxidant properties (Majid et al, 2015;Safriani et al, 2021). Currently, many studies have been carried out to scientifically prove the efficacy of medicinal plants for health.…”

Section: Introductionmentioning

confidence: 99%

The Combination of Phyllanthus niruri, Euphorbia hirta, and Loranthus sp. as a Source of Antioxidant Agents

Kristiani

Kasmiyati

2021

J Bio Bio Edu

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Meniran (Phyllanthus niruri), patikan kebo (Euphorbia hirta), and benalu (Loranthus sp.) have often been used by people as medicinal plants. This research aimed to measure the levels of flavonoids, phenolics, and ascorbic acid compounds, as well as the Free Radical Scavenging (FRS) activity of ethyl acetate extract from the mixture of P. niruri, E. hirta, and Loranthus sp. The FRS activity was measured with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The level of compounds was measured by using the spectrophotometry method with specific reagents. The result of the FRS activity in ethyl acetate extract from the mixture of P. niruri, E. hirta, and Loranthus sp. varied depending on its dose. The measure of FRS in the P. niruri: E. hirta: Loranthus sp 0:0:1 (K-OOL) composition showed a strong result with a value of IC50 97.2 ± 2.1 ppm, while in the 0:0.5:0.5 (K-OEL) composition it was moderate with a value of IC50 147.6 ± 6.5 ppm. The other compositions showed weak and inactive results. The K-OOL composition had the highest flavonoid and phenolic content that were 298.8±0.00 mg QE/g extract and 141.5±2.85 mg GAE/g extract respectively. The composition with the highest ascorbic acid content (298.8±0.00 mg/g extract) was K-OEO composition. So far, research on medicinal plants is still limited to one type of plant. The combination of several types of plants in several formulations allows obtaining a composition that can produce maximum antioxidant capacity. Therefore, this research is expected to produce a combination formulation of various types of medicinal plants that have the K-OOL composition very strong antioxidant activity and can be used as herbal medicines.

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“…The IC50 for the cell lines was less than or equal to 4.506 µg/mL for 48 h and 72 h, except for MCF-7 at 72 h, which had an IC50 of 18.86 µg/mL (Table 1). These values are below the American National Cancer Institute's (NCI) recommended upper IC50 limit of 30 µg/mL for purification of crude extracts, 28,29 validating the use of X. aethiopica in the prevention and treatment of cancer. The presence of significant alkaloids, saponin, and flavonoids in X. aethiopica 30 also gives credence to its use as an antitumor agent.…”

Section: Resultsmentioning

confidence: 83%

Cytotoxic Assessment of Xylopia aethiopica [Dun.] A. on Human Prostate and Breast Cancer Cell Lines

Iweala¹,

Bankole²,

Iheagwam³

et al. 2021

TJNPR

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Cancer is associated with the unregulated multiplication of cells in specific parts of the body. Plant-derived products are employed in the treatment and management of such malignant tumours. Prostate and breast cancers are the most common forms affecting Nigerians. Our aim is to investigate the cytotoxic effect of Xylopia aethiopica, a commonly consumed spice in Nigeria, on selected cancer cell lines. The antiproliferative activity of X. aethiopica ethanol extract of varying concentrations was assessed on MDA-MB-231, MCF-7, and LNCaP using MTT assay. A dose-dependent antiproliferative activity was observed. The IC50 for X. aethiopica on the cell lines were ≤ 4.506 ± 0.07 µg/mL except for MCF-7 at 72 hours, where 18.86 ± 0.20 µg/mL was recorded. The findings from this study indicate the potential antiproliferative and cytotoxic property of X. aethiopica on human prostate and breast cancer cell lines.

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Characterization of volatile compounds of <i>Albertisia papuana</i> Becc root extracts and cytotoxic activity in breast cancer cell line T47D

Cited by 6 publications

References 7 publications

Potential Synergy between Spores of Metarhizium anisopliae and Plant Secondary Metabolite, 1-Chlorooctadecane for Effective Natural Acaricide Development

Potential Synergy between Spores of Metarhizium anisopliae and Plant Secondary Metabolite, 1-Chlorooctadecane for Effective Natural Acaricide Development

The Combination of Phyllanthus niruri, Euphorbia hirta, and Loranthus sp. as a Source of Antioxidant Agents

Cytotoxic Assessment of Xylopia aethiopica [Dun.] A. on Human Prostate and Breast Cancer Cell Lines

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