Characterization of White Matter Tracts by Diffusion MR Tractography in Cat and Ferret that Have Similar Gyral Patterns

Das, Avilash; Takahashi, Emi

doi:10.1093/cercor/bhx048

Cited by 9 publications

(8 citation statements)

References 66 publications

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“…Tractography algorithms can lead to false connections or premature terminations of tracked fibers and thus be responsible for an anatomical inaccuracy between MRI-derived reconstruction and dissection (43). Similarly to our findings regarding the inferior fronto-occipital fasciculus, reconstruction of tracts that could not be identified on gross anatomical dissection has already been reported for the feline inferior fronto-occipital fasciculus (24,25,27,35) and the human superior fronto-occipital fasciculus (44,45). For this latter fasciculus, modeling errors are assumed to have generated false continuations between different projection fibers, thus leading to the reconstruction of a continuous fronto-occipital fiber bundle (45).…”

Section: Discussionsupporting

confidence: 79%

“…As DTI tractography assesses the structural integrity of white matter, it has been widely used for prognostic and/or diagnostic purposes in various brain pathologies such as stroke (3)(4)(5)(6), neurodegenerative diseases (7)(8)(9)(10)(11), and brain tumors (12). With the increasing availability of high-field-strength MRI (1.5 and 3 T) in veterinary facilities (13)(14)(15)(16)(17), the use of this technique is now gradually growing for the description of white matter anatomy and structural connectivity of domestic mammals (dog, cat, ferret, and sheep) (18)(19)(20)(21)(22)(23)(24)(25)(26)(27). These collected anatomical data are of particular interest as they might have applications in both veterinary medicine and experimental research.…”

Section: Introductionmentioning

confidence: 99%

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Diffusion Tensor Imaging Tractography of White Matter Tracts in the Equine Brain

et al. 2020

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Tractography, a noninvasive technique tracing brain pathways from diffusion tensor magnetic resonance imaging (DTI) data, is increasingly being used for brain investigation of domestic mammals. In the equine species, such a technique could be useful to improve our knowledge about structural connectivity or to assess structural changes of white matter tracts potentially associated with neurodegenerative diseases. The goals of the present study were to establish the feasibility of DTI tractography in the equine brain and to provide a morphologic description of the most representative tracts in this species. Postmortem DTI and susceptibility-weighted imaging (SWI) of an equine brain were acquired with a 3-T system using a head coil. Association, commissural, and projection fibers, the three fiber groups typically investigated in tractography studies, were successfully reconstructed and overlaid on SWI or fractional anisotropy maps. The fibers derived from DTI correlate well with their description in anatomical textbooks. Our results demonstrate the feasibility of using postmortem DTI data to reconstruct the main white matter tracts of the equine brain. Further DTI acquisitions and corresponding dissections of equine brains will be necessary to validate these findings and create an equine stereotaxic white matter atlas that could be used in future neuroimaging research.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Diffusion Tensor Imaging Tractography of White Matter Tracts in the Equine Brain

et al. 2020

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“…The inferior fronto-occipital fasciculus is not included in the atlas, as it was not identified even with liberal seed regions placed over the entire frontal and occipital regions. This fasciculus has been previously reconstructed in the feline using tractography (Jacqmot et al, 2017;Das and Takahashi, 2018). Although neuroanatomical connectivity analysis of the cat has shown both efferent and afferent connection between frontal and occipital regions (Scannell et al, 1995), the presence of a fronto-occipital fasciculus has not been identified on gross anatomic dissection (Pascalau et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Stereotaxic Diffusion Tensor Imaging White Matter Atlas for the in vivo Domestic Feline Brain

et al. 2020

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The cat brain is a useful model for neuroscientific research and with the increasing use of advanced neuroimaging techniques there is a need for an open-source stereotaxic white matter brain atlas to accompany the cortical gray matter atlas, currently available. A stereotaxic white matter atlas would facilitate anatomic registration and segmentation of the white matter to aid in lesion localization or standardized regional analysis of specific regions of the white matter. In this article, we document the creation of a stereotaxic feline white matter atlas from diffusion tensor imaging (DTI) data obtained from a population of eight mesaticephalic felines. Deterministic tractography reconstructions were performed to create tract priors for the major white matter projections of Corpus callosum (CC), fornix, cingulum, uncinate, Corona Radiata (CR), Corticospinal tract (CST), inferior longitudinal fasciculus (ILF), Superior Longitudinal Fasciculus (SLF), and the cerebellar tracts. T1-weighted, fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) population maps were generated. The volume, mean tract length and mean FA, MD, AD and RD values for each tract prior were documented. A structural connectome was then created using previously published cortical priors and the connectivity metrics for all cortical regions documented. The provided white matter atlas, diffusivity maps, tract priors and connectome will be a valuable resource for anatomical, pathological and translational neuroimaging research in the feline model. Multi-atlas population maps and segmentation priors are available at Cornell's digital repository: https://ecommons.cornell.edu/handle/1813/58775.2.

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“…Recent pioneering studies using diffusion MR tractography reported that ferrets (Mustela putorius furo), like humans and monkeys, also have abundant U-fibers [23,24]. Ferrets have a long history in research and have relatively well-developed brain structures such as cortical folds (i.e.…”

Section: Introductionmentioning

confidence: 99%

The origin and development of subcortical U-fibers in gyrencephalic ferrets

et al. 2020

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In the white matter of the human cerebrum, the majority of cortico-cortical fibers are of short range, connecting neighboring cortical areas. U-fibers represent connections between neighboring areas and are located in the white matter immediately deep to the cerebral cortex. Using gyrencephalic carnivore ferrets, here we investigated the neurochemical, anatomical and developmental features of U-fibers. We demonstrate that U-fibers were derived from neighboring cortical areas in ferrets. U-fiber regions in ferrets were intensely stained with Gallyas myelin staining and Turnbull blue iron staining. We further found that U-fibers were derived from neurons in both upper and lower layers in neighboring areas of the cerebral cortex and that U-fibers were formed later than axons in the deep white matter during development. Our findings shed light on the fundamental features of U-fibers in the gyrencephalic cerebral cortex. Because genetic manipulation techniques for ferrets are now available, ferrets should be an important option for investigating the development, functions and pathophysiological changes of U-fibers.

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Characterization of White Matter Tracts by Diffusion MR Tractography in Cat and Ferret that Have Similar Gyral Patterns

Cited by 9 publications

References 66 publications

Diffusion Tensor Imaging Tractography of White Matter Tracts in the Equine Brain

Diffusion Tensor Imaging Tractography of White Matter Tracts in the Equine Brain

Stereotaxic Diffusion Tensor Imaging White Matter Atlas for the in vivo Domestic Feline Brain

The origin and development of subcortical U-fibers in gyrencephalic ferrets

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