Characterization of α-carrageenan solution behavior by field-flow fractionation and multiangle light scattering

Bourgoin, Angelique; Zablackis, Earl; Poli, Janet B.

doi:10.1016/j.foodhyd.2007.11.001

Cited by 16 publications

(10 citation statements)

References 20 publications

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“…Carragennan comprises a group of linear sulphated polysaccharides extracted from red seaweeds, with a primary structure based on an alternating disaccharide repeating unit of ␣-(1-3)d-galactose-4-sulphate and ␤-(1-4) 3,6-anydro-d-galactose (AG) being the structures classified into three main commercial types based on the presence of the 3,6-anydro-d-galactose on the 4linked residue and the position and number of sulphate groups: kappa (), iota (), and lambda (). They are commonly used as thickener, gelling agent, and stabilizer in the food and pharmaceutical industries (Bourgoin, Zablackis, & Poli, 2008), and have been successfully used as colloidal stabilizer in the synthesis of magnetic iron oxide nanoparticles, preventing the spontaneous agglomeration of the nanoparticles (Daniel-da-Silva, Trindade, Goodfellow, Costa, Correia, & Gil, 2007).…”

Section: Introductionmentioning

confidence: 99%

Influence of concentration, ionic strength and pH on zeta potential and mean hydrodynamic diameter of edible polysaccharide solutions envisaged for multinanolayered films production

Carneiro-da-Cunha

Cerqueira

Souza

et al. 2011

Carbohydrate Polymers

235

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Polysaccharide multinanolayers are becoming a new and general means of modifying and functionalizing surfaces of several materials. This is achieved through changing the interfacial properties of those surfaces followed by sequential adsorption of e.g., polysaccharides. Knowledge of properties of polysaccharide solutions such as zeta potential (Zp) and mean hydrodynamic diameter (Z-average) is crucial to obtain stable, functional nanostructures. In this work sodium alginate, carragennan, chitosan, and two galactomannans were characterized in terms of Zp and Z-average, as a function of polysaccharides and NaCl concentrations and pH. The most relevant effects of these factors on Zp and on Z-average were analysed using a 2 3 full factorial design. With a few exceptions, the effect of independent variables on Zp and Z-average values is statistically significant. In general (except for k-carragennan solutions) higher polysaccharide concentrations lead to higher Z-average values; and higher pH values lead to higher Z-average values (except for solutions of chitosan and galactomannan of Gleditsia triacanthos). NaCl addition decreases Z-average. For the galactomannans solutions Zp values were found to be neutral (ranging from −13.7 to −2.1 mV) independently of the combinations of variables used. This work establishes a relationship between important polysaccharides properties and the values of pH, polysaccharide and salt concentrations, thus providing insight on how to control the structure and texture of multinanolayered films in view of their potential application e.g., in the food, pharmaceutical, and cosmetic industries.

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Section: Introductionmentioning

confidence: 99%

Influence of concentration, ionic strength and pH on zeta potential and mean hydrodynamic diameter of edible polysaccharide solutions envisaged for multinanolayered films production

Carneiro-da-Cunha

Cerqueira

Souza

et al. 2011

Carbohydrate Polymers

235

View full text Add to dashboard Cite

show abstract

“…Such observation might be due to the formation of very loose aggregates that undergo severe changes upon incubation such as the fusion of aggregates. Further studies are, however, required using other techniques such as the Asymmetrical Field-Flow Fractionation (AFFF), which allows not only to characterize nanoparticles [33] but also the behavior of macromolecules in solution [34].…”

Section: Tablementioning

confidence: 99%

Poly(malic acid) bearing Doxorubicin and N-Acetyl Galactosamine as a site-specific prodrug for targeting hepatocellular carcinoma

Venkatraj

Nanjan

Loyer

et al. 2017

Journal of Biomaterials Science, Polymer Edition

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In the past, several systems of drug delivery carriers have been designed with a high capacity to target specific cells and/or tissues and a reduced non-specific toxicity. In this context, we synthesized and characterized novel poly(malic acid) derivatives bearing Doxorubicin (Dox), Poly(ethylene glycol) (PEG) and/or N-Acetyl Galactosamine (NAcGal) for drug delivery. These poly(malic acid) derivatives were obtained by chemical modification of the carboxylic acid lateral groups of poly(malic acid) (PMLA). The resulting nanoplatforms were evaluated for their in vitro cytotoxicity using the human HepaRG hepatoma cell line. Results reveal that the PMLA nanoplatform modified with PEG and Dox has an IC of 936 nM corresponding to a Dox concentration of 47 nM, while the grafting of NAcGal onto the nanoplatform reduced the IC to 527 nM corresponding to a Dox concentration of 26 nM. The presence of the targeting moiety, NAcGal, thus improves the cellular toxicity of the Dox.

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“…This has proven to be complementary to HPSEC for large polymers such as starches, carrageenans (Bourgoin et al 2008) etc., however, to our knowledge, there has been very limited application to vaccine polysaccharides (or conjugates). The sample domain extends from about 1 nm to 100 µm without stationary phase interactions or large applied forces.…”

Section: Molecular Sizementioning

confidence: 99%

Vaccine Analysis: Strategies, Principles, and Control

Nunnally¹,

Turula²,

Sitrin³

2015

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Characterization of α-carrageenan solution behavior by field-flow fractionation and multiangle light scattering

Cited by 16 publications

References 20 publications

Influence of concentration, ionic strength and pH on zeta potential and mean hydrodynamic diameter of edible polysaccharide solutions envisaged for multinanolayered films production

Influence of concentration, ionic strength and pH on zeta potential and mean hydrodynamic diameter of edible polysaccharide solutions envisaged for multinanolayered films production

Poly(malic acid) bearing Doxorubicin and N-Acetyl Galactosamine as a site-specific prodrug for targeting hepatocellular carcinoma

Vaccine Analysis: Strategies, Principles, and Control

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