Characterizing electroosmotic flow in microfluidic devices

Gaudioso, Jennifer M; Craighead, Harold G.

doi:10.1016/s0021-9673(02)00843-9

Cited by 71 publications

(75 citation statements)

References 17 publications

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“…The Knudsen number K n = mean free path characteristic size indicates whether a continuous model is adapted (K n < 0.01) or if a semi-discrete [22,23] or discrete [24,25,26] model is needed to account for nanoscale phenomena such as adsorption on walls, electrostatic forces or steric exclusion [27,28,29].…”

Section: Breakdown Of Continuity In Water Microfluidicsmentioning

confidence: 99%

Visco-acoustic modelling of a vibrating plate interacting with water confined in a domain of micrometric size

Lebental

Bourquin

2012

Journal of Sound and Vibration

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To cite this version:Bérengère Lebental, Frédéric Bourquin. Visco-acoustic modelling of a vibrating plate interacting with water confined in a domain of micrometric size. Journal of Sound and Vibration, Elsevier, 2012, 331 (8) AbstractIt is well established that concrete durability strongly depends on the capillary porosity of the material. Hence, structural health monitoring of concrete structure could take advantage of concrete microporosity monitoring. To this end, a new method for the in situ non-destructive testing of capillary porosity in cementitious materials has been proposed. A sensing device that seems well suited to this application is a capacitive ultrasonic transducer with a characteristic size of 1 µm. It is to be embedded in the material. Its vibrating membrane is made of aligned carbon nanotubes forming a thin layer with a typical thickness of 1 nm. It generates acoustic waves of micrometric wavelength into water-filled micropores, aiming at measuring their properties.The present paper focuses on the numerical simulation of the embedded sensor. In order to properly account for viscous effects in fluids at the micrometric scale, we have developed a specific computational method for the visco-acoustic modelling of a microplate vibrating between 10 MHz and 2 GHz in a water-filled domain of micrometric size. Our approach is based on the condensation of the fluid part of the fluid-structure problem on the structure by a finite element method, and on a spectral approximation of the structural equations.The numerical results indicate that the fluid domain is resonant despite the viscous terms, which causes a frequency downshift of the resonances and a decrease of the quality factor. In the coupled sys- the pore width, which makes the device a good candidate as a porosity sensor.

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Section: Breakdown Of Continuity In Water Microfluidicsmentioning

confidence: 99%

Visco-acoustic modelling of a vibrating plate interacting with water confined in a domain of micrometric size

Lebental

Bourquin

2012

Journal of Sound and Vibration

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“…The EOF in hot embossed zeonor devices was studied by Gaudioso and Craighead [66]. While no EOF was observed in untreated channels, a cathodic EOF indicating a negative surface charge was found in channels oxidized in an oxygen plasma before the bonding step.…”

Section: Zeonor Substratesmentioning

confidence: 99%

Surface modification in microchip electrophoresis

2003

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Different approaches and techniques for surface modification of microfluidic devices applied for microchip electrophoresis are reviewed. The main focus is on the improved electrophoretic separation by reducing analyte-wall interactions and manipulation of electroosmosis. Approaches and methods for permanent and dynamic surface modification of microfluidic devices, manufactured from glass, quartz and also different polymeric substrates, are described.

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“…The wide variety of polymer surface modification techniques that have been developed are covered in several excellent reviews. [11][12][13][14][15] While a few other methods have been used, [16][17][18][19] modification of COC surfaces has primarily been accomplished using photografting. [20][21][22][23][24] Photografting is typically initiated by a photoinitiator, such as benzophenone (BP); UV excitation promotes abstraction of hydrogen atoms from the polymer surface, leading to the formation of surface-bound radicals that may then initiate a surface graft polymerization process.…”

Section: Introductionmentioning

confidence: 99%

Cyclic olefin copolymer based microfluidic devices for biochip applications: Ultraviolet surface grafting using 2-methacryloyloxyethyl phosphorylcholine

Jena

Yue

2012

Biomicrofluidics

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This report studies the surface modification of cyclic olefin copolymer (COC) by 2-methacryloyloxyethyl phosphorylcholine (MPC) monomer using photografting technique for the purpose of biointerface applications, which demonstrate resistance to both protein adsorption and cell adhesion in COC-based microfluidic devices. This is essential because the hydrophobic nature of COC can lead to adsorption of specific compounds from biological fluids in the microchannel, which can affect the results during fluidic analysis and cause clogging inside the microchannel. A correlation was found between the irradiation time and hydrophobicity of the modified substrate. Static water contact angle results show that the hydrophilicity property of the MPC-grafted substrate improves with increasing irradiation time. The contact angle of the modified surface decreased to 20 6 5 from 88 6 3 for the untreated substrate. The surface characterization of the modified surface was evaluated using x-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR spectroscopy). Attenuated total reflection-FTIR and XPS results show the presence of the phosphate group (P-O) on modified COC substrates, indicating that the hydrophilic MPC monomer has successfully grafted on COC. Finally, it was demonstrated that cell adhesion and protein adsorption on the MPC modified COC specimen has reduced significantly.

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Characterizing electroosmotic flow in microfluidic devices

Cited by 71 publications

References 17 publications

Visco-acoustic modelling of a vibrating plate interacting with water confined in a domain of micrometric size

Visco-acoustic modelling of a vibrating plate interacting with water confined in a domain of micrometric size

Surface modification in microchip electrophoresis

Cyclic olefin copolymer based microfluidic devices for biochip applications: Ultraviolet surface grafting using 2-methacryloyloxyethyl phosphorylcholine

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