2023
DOI: 10.1016/j.ejps.2023.106386
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Characterizing interspecies differences in gastric fluid properties to improve understanding of in vivo oral drug formulation performance

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Cited by 6 publications
(5 citation statements)
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“…The density and floatability in 0.1 N HCl (pH 1.2) of raft structures formed by GE-SD loaded formulations are listed in Table 1 . The density of raft structures ranged between 0.47 and 0.54 g/mL and thus floated in 0.1 N HCl which has a density close to that of water (1.00 g/mL) [ 38 ]. Upon contact with 0.1 N HCl solution, Ca 2+ ions released by calcium carbonate in the liquid formulation interact with negatively charged sodium alginate, resulting in ionic crosslinks and formation of a hydrogel.…”
Section: Resultsmentioning
confidence: 99%
“…The density and floatability in 0.1 N HCl (pH 1.2) of raft structures formed by GE-SD loaded formulations are listed in Table 1 . The density of raft structures ranged between 0.47 and 0.54 g/mL and thus floated in 0.1 N HCl which has a density close to that of water (1.00 g/mL) [ 38 ]. Upon contact with 0.1 N HCl solution, Ca 2+ ions released by calcium carbonate in the liquid formulation interact with negatively charged sodium alginate, resulting in ionic crosslinks and formation of a hydrogel.…”
Section: Resultsmentioning
confidence: 99%
“…For example, species and regional variation in gastrointestinal pH can change the ionization status of drugs that are weak acids or bases and so influence their absorption from the gastrointestinal tract after oral administration. The composition of gastrointestinal fluids also vary with species 25 and so will impact the rate and extent of drug dissolution depending on drug solubility characteristics. The epithelium of the gastrointestinal tract provides a physical barrier to the absorption of orally administered drugs and includes an unstirred mucus layer.…”
Section: Introductionmentioning
confidence: 99%
“…Surfactants are present in the digestive system to emulsify fats for transport and digestion [19][20][21][22].…”
Section: Introductionmentioning
confidence: 99%
“…Surfactants are found to occur naturally in foods, are added to commercially prepared foods, dishwashing detergents (DWD) and toothpastes [10][11][12][13]. Surfactants occur in saliva with a surface tension of 53-65mN/m, gastric fluid (43-54mN/m), the small intestine as bile salts (25-28mN/m which may also be present in gastric fluid) and in DWD (22-35 mN/m) [19][20][21][22][23]. An in vitro study to show how SF influence the digestibility of the fat tricaprylin, in the presence of the SF polysorbate 80 found that at low SF concentrations and in the presence of other types of SF (bile salts and phospholipids), adsorbed SF molecules can be displaced and allow lipolysis to occur in a concentration dependent manner [24].…”
Section: Introductionmentioning
confidence: 99%
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