Characterizing mechanism-based pain phenotypes in patients with chronic pancreatitis: a cross-sectional analysis of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies

Saloman, Jami L.; Conwell, Darwin L.; Fogel, Evan L.; Vege, Santhi Swaroop; Li, Liang; Li, Shuang; Andersen, Dana K.; Fisher, William E.; Forsmark, Christopher E.; Hart, Phil A.; Pandol, Stephen J.; Park, Walter G.; Phillips, Anna E.; Topazian, Mark D.; Eeden, Stephen K. Van Den; Serrano, José; Yadav, Dhiraj

doi:10.1097/j.pain.0000000000002710

Cited by 6 publications

(1 citation statement)

References 41 publications

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“…A differentiation between neuropathic and nociceptive types of pain in CP patients who reported specific patterns in their experience on pain surveys showed worse overall health and QOL in those with both types of pain, suggesting that patient-reported outcome tools may serve a useful role in phenotyping the pain experience from a patient perspective. [59] Early complementary work in human serum biomarkers has shown that TGFb1 and GP130 may be promising targets for further investigation into biological identification of neuropathic and nociceptive pain. [60] Despite a lack of correlation between imaging findings and pain experience in CP, pancreatic duct obstruction has long been thought to contribute independently to the pain experience, and is a major target of treatment in this population.…”

Section: Pain Phenotypingmentioning

confidence: 99%

Recent advances in the understanding and management of chronic pancreatitis pain

Walker,

Babyok,

Saloman

et al. 2023

Journal of Pancreatology

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Abdominal pain is the most common symptom of chronic pancreatitis (CP), and is often debilitating for patients and very difficult to treat. To date, there exists no cure for the disease. Treatment strategies focus on symptom management and on mitigation of disease progression by reducing toxin exposure and avoiding recurrent inflammatory events. Traditional treatment protocols start with medical management followed by consideration of procedural or surgical intervention on selected patients with severe and persistent pain. The incorporation of adjuvant therapies to treat comorbidities including psychiatric disorders, exocrine pancreatic insufficiency, mineral bone disease, frailty, and malnutrition, are in their early stages. Recent clinical studies and animal models have been designed to improve investigation into the pathophysiology of CP pain, as well as to improve pain management. Despite the array of tools available, many therapeutic options for the management of CP pain provide incomplete relief. There still remains much to discover about the neural regulation of pancreas-related pain. In this review we will discuss research from the last five years that has provided new insights into novel methods of pain phenotyping and the pathophysiology of CP pain. These discoveries have led to improvements in patient selection for optimization of outcomes for both medical and procedural management, and identification of potential future therapies.

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Section: Pain Phenotypingmentioning

confidence: 99%