Ettore Majorana (1906Majorana ( -1938 disappeared while traveling by ship from Palermo to Naples in 1938. His fate has never been fully resolved and several articles have been written that explore the mystery itself. His demise intrigues us still today because of his seminal work, published the previous year, that established symmetric solutions to the Dirac equation that describe a fermionic particle that is its own anti-particle. This work has long had a significant impact in neutrino physics, where this fundamental question regarding the particle remains unanswered. But the formalism he developed has found many uses as there are now a number of candidate spin-1 2 neutral particles that may be truly neutral with no quantum number to distinguish them from their anti-particles. If such particles exist, they will influence many areas of nuclear and particle physics. Most notably the process of neutrinoless double beta decay can only exist if neutrinos are massive Majorana particles. Hence, many efforts to search for this process are underway. Majorana's influence doesn't stop with particle physics, however, even though that was his original consideration. The equations he derived also arise in solid state physics where they describe electronic states in materials with superconducting order. Of special interest here is the class of solutions of the Majorana equation in one and two spatial dimensions at exactly zero energy. These Majorana zero modes are endowed with some remarkable physical properties that may lead to advances in quantum computing and, in fact, there is evidence that they have been experimentally observed. This review first summarizes the basics of Majorana's theory and its implications. It then provides an overview of the rich experimental programs trying to find a fermion that is its own anti-particle in nuclear, particle, and solid state physics.