Characterizing the kinetics of presepsin and associated inflammatory biomarkers in human endotoxemia

Abstract

In this study, we describe the kinetics of a new potential inflammatory biomarker, presepsin, together with a panel of well-established biomarkers in a human endotoxemia study. We evaluated biomarker correlations and identified combinations that could hold valuable insights regarding the state of infection.

Modelling inflammatory biomarker dynamics in a human lipopolysaccharide (LPS) challenge study using delay differential equations

“…Correlations between cytokines were also evaluated in previous studies. 2,6,10,27 TNF-α was shown to induce the IL-8 expression in human micro vessel endothelial cell lines, 28 while a stimulatory effect of TNF-α on IL-6 production was established in piglets. 10 In our study, a simultaneously estimated model including all the inflammatory biomarkers was tested to evaluate correlations between cytokines.…”

“…Correlations between cytokines were also evaluated in previous studies 2,6,10,27 . TNF‐α was shown to induce the IL‐8 expression in human micro vessel endothelial cell lines, 28 while a stimulatory effect of TNF‐α on IL‐6 production was established in piglets 10 .…”

A Potential Biomarker Candidate for Neonatal Calf Septicemia: Presepsin: Traditional Review

“…Presepsin molekülünün vücuttan uzaklaştırılması başlıca renal yol ile sağlanmakta iken, daha az oranda ise hepato-bilier sistem aracılığı ile gerçekleştirilmektedir. 48,49 Presepsin molekülünün; sepsisin patofizyolojisinde bizzat yer almasından ötürü, diğer biyobelirteçlerin bir adım önüne geçmesi muhtemel gibi gözükmektedir fakat insan hekimliğinde, plazmadaki presepsin düzeylerinin yalnızca pg/mL gibi küçük seviyelerde kaldığını gösteren çok sayıda çalışmaya rastlanmaktadır. Prokalsitoninin aksine viral kökenli enfeksiyonlarda da presepsin düzeylerinde anlamlı artışlar gösterilmiştir.…”