Charge-Switchable Nanozymes for Bioorthogonal Imaging of Biofilm-Associated Infections

Gupta, Akash; Das, Rahul; Tonga, Gülen Yesilbag; Mizuhara, Tsukasa; Rotello, Vincent M.

doi:10.1021/acsnano.7b07496

Cited by 165 publications

(154 citation statements)

References 38 publications

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“…A great number of nanoparticles have factored in the superiority of unique endogenous features in the tumor microenvironment, including specific proteases, hypoxia, and low extracellular pH, which allow nanosystems to accumulate in the pathologic sites and release the payloads in response to these stimuli for cancer diagnosis and treatment …”

Section: Nanoparticles Regulating the Tmementioning

confidence: 99%

Nanoparticle‐Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions

Liu

Zhang

2019

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124

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Cancer immunotherapy is a promising cancer terminator by directing the patient's own immune system in the fight against this challenging disorder. Despite the monumental therapeutic potential of several immunotherapy strategies in clinical applications, the efficacious responses of a wide range of immunotherapeutic agents are limited in virtue of their inadequate accumulation in the tumor tissue and fatal side effects. In the last decades, increasing evidences disclose that nanotechnology acts as an appealing solution to address these technical barriers via conferring rational physicochemical properties to nanomaterials. In this Review, an imperative emphasis will be drawn from the current understanding of the effect of a nanosystem's structure characteristics (e.g., size, shape, surface charge, elasticity) and its chemical modification on its transport and biodistribution behavior. Subsequently, rapid‐moving advances of nanoparticle‐based cancer immunotherapies are summarized from traditional vaccine strategies to recent novel approaches, including delivery of immunotherapeutics (such as whole cancer cell vaccines, immune checkpoint blockade, and immunogenic cell death) and engineered immune cells, to regulate tumor microenvironment and activate cellular immunity. The future prospects may involve in the rational combination of a few immunotherapies for more efficient cancer inhibition and elimination.

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Section: Nanoparticles Regulating the Tmementioning

confidence: 99%

Nanoparticle‐Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions

Liu

Zhang

2019

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124

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“…D) Biofilm imaging by using biorthogonal reactions catalyzed by nanozyme. [70] Reproduced from ref. [70] with permission; copyright: 2018, American Chemical Society.…”

Section: Antioxidationmentioning

confidence: 99%

“…In 2018, a charge-switchable nanozyme was used in biorthogonal imaging of biofilm-associated infections. [70] The nanozymes were generated through the encapsulation of a ruthenium-based catalyst into the ligand monolayer of 2 nm gold nanoparticles. When attaching onto the biofilm, the nanoparticle surface could be activated by the high cationic environment.…”

Section: Bioorthogonal Catalysismentioning

confidence: 99%

Enzyme Mimic Nanomaterials and Their Biomedical Applications

et al. 2020

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Nanomaterials with enzyme‐mimicking behavior (nanozymes) have attracted a lot of research interest recently. In comparison to natural enzymes, nanozymes hold many advantages, such as good stability, ease of production and surface functionalization. As the catalytic mechanism of nanozymes is gradually revealed, the application fields of nanozymes are also broadly explored. Beyond traditional colorimetric detection assays, nanozymes have been found to hold great potential in a variety of biomedical fields, such as tumor theranostics, antibacterial, antioxidation and bioorthogonal reactions. In this review, we summarize nanozymes consisting of different nanomaterials. In addition, we focus on the catalytic performance of nanozymes in biomedical applications. The prospects and challenges in the practical use of nanozymes are discussed at the end of this Minireview.

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“…Due to the encapsulation of EPS and fermentation of bacteria inside biofilm, the biofilm microenvironment has several characteristics, such as the lack of oxygen, low pH, and high level of H 2 O 2 compared with healthy tissues [24][25][26][27][28][29]. Hence, biofilm microenvironment is an ideal target for specific diagnosis and treatment of biofilm-related infection diseases [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

“…Hence, biofilm microenvironment is an ideal target for specific diagnosis and treatment of biofilm-related infection diseases [29][30][31]. Previous studies have demonstrated the use of charge-switchable nanozymes to respond the acidic biofilm microenvironment through bioorthogonal reaction to activate profluorophores and realize specific fluorescence detection of biofilm in vitro [24]. Moreover, pH-responsive Au nanoparticles and micellar nanocarriers have also been designed to combat bacterial biofilm infections [32,33].…”

Section: Introductionmentioning

confidence: 99%

Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections

et al. 2020

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The formation of bacterial biofilms closely associates with infectious diseases. Until now, precise diagnosis and effective treatment of bacterial biofilm infections are still in great need. Herein, a novel multifunctional theranostic nanoplatform based on MnO2 nanosheets (MnO2 NSs) has been designed to achieve pH-responsive dual-mode imaging and hypoxia-relief-enhanced antimicrobial photodynamic therapy (aPDT) of bacterial biofilm infections. In this study, MnO2 NSs were modified with bovine serum albumin (BSA) and polyethylene glycol (PEG) and then loaded with chlorin e6 (Ce6) as photosensitizer to form MnO2-BSA/PEG-Ce6 nanosheets (MBP-Ce6 NSs). After being delivered into the bacterial biofilm-infected tissues, the MBP-Ce6 NSs could be decomposed in acidic biofilm microenvironment and release Ce6 with Mn2+, which subsequently activate both fluorescence (FL) and magnetic resonance (MR) signals for effective dual-mode FL/MR imaging of bacterial biofilm infections. Meanwhile, MnO2 could catalyze the decomposing of H2O2 in biofilm-infected tissues into O2 and relieve the hypoxic condition of biofilm, which significantly enhances the efficacy of aPDT. An in vitro study showed that MBP-Ce6 NSs could significantly reduce the number of methicillin-resistant Staphylococcus aureus (MRSA) in biofilms after 635 nm laser irradiation. Guided by FL/MR imaging, MRSA biofilm-infected mice can be efficiently treated by MBP-Ce6 NSs-based aPDT. Overall, MBP-Ce6 NSs not only possess biofilm microenvironment-responsive dual-mode FL/MR imaging ability but also have significantly enhanced aPDT efficacy by relieving the hypoxia habitat of biofilm, which provides a promising theranostic nanoplatform for bacterial biofilm infections.

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Charge-Switchable Nanozymes for Bioorthogonal Imaging of Biofilm-Associated Infections

Cited by 165 publications

References 38 publications

Nanoparticle‐Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions

Nanoparticle‐Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions

Enzyme Mimic Nanomaterials and Their Biomedical Applications

Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections

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