Charge transfer complexes (CTC) of trazodone hydrochloride (TZD) with picric acid (PA), 2,3dichloro-5,6-dicyano-p-benzoquinone (DDQ), tetracyanoquinodimethane (TCNQ), 2,6-dichloroquinone-4chloroimide (DCQ), 2,6-dibromoquinone-4-chloroimide (DBQ), and N-bromosuccinimide (NBS) have been synthesized and studied using conductivity, UV-Vis, infrared, Raman and 1 H NMR spectroscopy. The stoichiometries of the complexes were found to be 1 : 1. Kinetic thermodynamic parameters (E * , A, ΔS * , ΔH * , and ΔG * ) were also calculated using Coats-Redfern and Horowitz-Metzger equations.