Charlotte Friend, Ph.D. 1921‐1987 A Scientist's Life

Diamond, Leila; Wolman, Sandra R.

doi:10.1111/j.1749-6632.1989.tb16454.x

Cited by 1 publication

(1 citation statement)

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“…These groundbreaking discoveries indicated that cancer could be caused by viruses, a novel paradigm which was not widely accepted at that time. In fact, researchers supporting the concept of viruses causing cancer were said to either have “ holes in their heads or holes in their filters ” [ 4 ]. Nevertheless, especially the Rous sarcoma virus (RSV), a paradigmatic species of the alpharetroviral genus, played an important role in the history of retrovirology and in cancer research ( Figure 1 ).…”

Section: History Of (Alpha-) Retrovirusesmentioning

confidence: 99%

Alpharetroviral Vectors: From a Cancer-Causing Agent to a Useful Tool for Human Gene Therapy

Suerth

Labenski

Schambach

2014

Viruses

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Gene therapy using integrating retroviral vectors has proven its effectiveness in several clinical trials for the treatment of inherited diseases and cancer. However, vector-mediated adverse events related to insertional mutagenesis were also observed, emphasizing the need for safer therapeutic vectors. Paradoxically, alpharetroviruses, originally discovered as cancer-causing agents, have a more random and potentially safer integration pattern compared to gammaretro- and lentiviruses. In this review, we provide a short overview of the history of alpharetroviruses and explain how they can be converted into state-of-the-art gene delivery tools with improved safety features. We discuss development of alpharetroviral vectors in compliance with regulatory requirements for clinical translation, and provide an outlook on possible future gene therapy applications. Taken together, this review is a broad overview of alpharetroviral vectors spanning the bridge from their parental virus discovery to their potential applicability in clinical settings.

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Section: History Of (Alpha-) Retrovirusesmentioning

confidence: 99%