Chemosensory detection of airborne chemicals by humans is accomplished principally through olfaction and mucosal chemesthesis. Odors are perceived via stimulation of the olfactory nerve (CN I) whereas nasal chemesthetic sensations (i.e., prickling, irritation, stinging, burning, freshness, piquancy, etc), grouped under the term nasal pungency, are mediated by the trigeminal nerve (CN V). Airborne compounds elicit odor sensations at concentrations orders of magnitude below those producing pungency but the physicochemical basis for odor and 3 pungency potency of chemicals, either singly or in mixtures, is far from being understood. The sensitivity of the sense of smell often outperforms that of the most sophisticated chemicoanalytical methods like gas chromatography and mass spectrometry. Still, the combined used of these techniques with human odor detection (i.e., olfactometry) has proved an invaluable tool to understand the chemosensory properties of complex mixtures such as foods, flavors, and fragrances.
1) Human chemosensory perception of airborne chemicalsHumans detect the presence of volatile organic compounds (VOCs) in their surroundings principally through their senses of olfaction and "chemesthesis" [1,2]. The latter is also known as the "common chemical sense" [3,4]. Activation of the olfactory nerve (CN I) produces odor sensations. Chapter 3 describes the biological basis of this chemosensory pathway. Activation of chemoreceptors on the trigeminal nerve (CN V) innervating the face mucosae produces chemesthetic responses (see, for example, [5]). These responses evoked in the nose include stinging, piquancy, burning, freshness, tingling, irritation, prickling, and the like. All these nasal sensations can be grouped under the term nasal pungency [6]. Chemesthetic responses to airborne VOCs can also be produced in the ocular, oral, and upper airway mucosae, where they are referred to as eye, mouth, and throat irritation. In the case of the back of the mouth and the throat, other nerves, such as the glossopharyngeal (CN VIII) and vagus (CN X), are also stimulated by airborne VOCs and contribute to perceived irritation.In this chapter we will focus on human smell and nasal chemesthesis. We will review psychophysical studies performed on both sensory modalities addressing the possible basis for the odor and irritation potency of VOCs. We will also summarize various techniques that combine the power of the human nose with that of chemical-analytical instruments, such as gas chromatography and mass spectrometry, to quantify the chemosensory activity of volatile chemicals and to help understand better the characteristics of human chemosensory perception.
2) Nasal Chemosensory DetectionOdor thresholds represent an important biological characteristic of airborne chemicals.Nevertheless, compilation of such values [7][8][9] show an extreme variability for any particular substance, even after attempting to standardize the values reported in different sources [10]. This scatter severely limits the practical applicatio...