Charting a Path toward Aggression

Ammari, Rachida; Kohl, Johannes

doi:10.1016/j.neuron.2020.04.029

Cited by 2 publications

(1 citation statement)

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“…Notably, patients with tumors located in the midbrain and pontin exhibited more aggressive behaviors in the present study. Conventionally, previously accumulated neuroscientific evidence suggested that the amygdala, hypothalamus, and periaqueductal (PAG) matter make up the subcortical circuits that are involved in aggression [ 31 ]. Additionally, it has been reported that the PAG region receives input of aggression from ventrolateral areas of the ventromedial hypothalamus [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Brainstem tumors may increase the impairment of behavioral emotional cognition in children

Jia

Zhang

et al. 2022

J Neurooncol

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Purpose It remains unclear as to whether patients with brainstem tumor experience complex neuropsychiatric problems. In this cohort study, we specifically investigated behavioral, emotional and cognitive symptoms in pediatric patients with brainstem glioma and healthy individuals. Methods A total of 146 patients with pediatric brainstem tumors (aged 4–18 years old) and 46 age-matched healthy children were recruited to assess their behaviors and emotions examined by the Child Behavior Checklist. A variety of clinical factors were also analyzed. Results There were significant differences in most behavioral and emotional symptoms between pediatric patients and healthy subjects. Moreover, patients with pons tumors exhibited significantly higher scores than patients with medulla oblongata tumors (p = 0.012), particularly in concerning the syndrome categories of Withdrawn (p = 0.043), Anxious/depressed symptoms (p = 0.046), Thought Problems (p = 0.004), Attention deficits (p = 0.008), Externalizing problems (p = 0.013), and Aggressive behavior (p = 0.004). A tumor body located in the pontine (p = 0.01, OR = 4.5, 95% CI = 1.4–14.059) or DIPG in the midbrain (p = 0.002, OR = 3.818, 95% CI = 1.629–8.948) appears to act as a risk factor that is associated with more problems in patients with neuropsychiatric symptoms. Conclusions Pediatric patients with brainstem tumors exhibit severe behavioral and emotional problems. Tumor invades the pontine and midbrain act a risk factor with more problems. It suggests that structural and functional abnormalities in the brainstem will cause prolonged behavioral problems and emotional-cognitive dysfunctions in young children.

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Section: Discussionmentioning

confidence: 99%