2023
DOI: 10.1101/2023.04.14.536833
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Charting spatial ligand-target activity using Renoir

Abstract: The advancement of single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics has made it possible to infer interactions amongst heterogeneous cells and their surrounding cellular environments. Existing methods assist in the analysis of ligand-receptor interactions by either adding spatial information to the currently available scRNA-seq data or utilizing spot-level or high-resolution spatial transcriptomics data. However, till date, there is a lack of methods capable of mapping ligand-target interacti… Show more

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Cited by 4 publications
(1 citation statement)
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“…Typically, these methods infer relationships between proteins 12,13 or cell types (cellular neighbourhoods) 14,15 . Spatially-informed methods differ in the scale at which interactions are inferred, as some infer relationships globally, summarising them across slides as a whole 12,13,16 , while others do so locally at the individual cell or spot locations within a slide [17][18][19][20] .…”
Section: Introductionmentioning
confidence: 99%
“…Typically, these methods infer relationships between proteins 12,13 or cell types (cellular neighbourhoods) 14,15 . Spatially-informed methods differ in the scale at which interactions are inferred, as some infer relationships globally, summarising them across slides as a whole 12,13,16 , while others do so locally at the individual cell or spot locations within a slide [17][18][19][20] .…”
Section: Introductionmentioning
confidence: 99%