Chebulanin exerts its anti-inflammatory and anti-arthritic effects via inhibiting NF-κB and MAPK activation in collagen-induced arthritis mice

Liu, Fang; Liu, Yao; Zhan, Shipeng; Lv, Jun; Sun, Fengjun; Weng, Bangbi; Liu, Songqin; Xia, Peiyuan

doi:10.1016/j.intimp.2020.106823

Cited by 16 publications

(17 citation statements)

References 41 publications

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“…These results confirm the potential role of chebulanin as a strong therapeutic agent for the treatment of RA. Recently, Liu et al also confirmed the AA activity of chebulanin via inhibiting NF-κB and MAPK activation in a collagen-induced arthritis (CIA)mouse model [58]. Chebulanin significantly decreased the arthritic scores, paw swelling and IL-6 and TNF-α level in mice after being orally gavaged (80 mg/kg) daily for a total of 21 days.…”

Section: Chebulaninmentioning

confidence: 87%

Antiarthritic Activities of Herbal Isolates: A Comprehensive Review

Jain¹,

Vaidya

Gupta

et al. 2021

Coatings

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Numerous plant isolates with therapeutic properties, such as antimicrobial, antiinflammatory, antiviral, antimalarial, antiarthritic (AA), hepatoprotective, cardiotonic, and so forth, are reported in the literature. Usually, medicinal plants are widely used, and assumed to be safe and cheaper alternatives to chemically synthesized drugs. However, they are not regulated for potency and purity, and thus care must be taken for their safe use. In this review, we aimed to compile all of the herbal isolates possessing AA properties, including alkaloids (montanine, 3-acetylaconitine, sanguinarine, jatrorrhizine hydrochloride, and piperine), terpenoids (eugenol, nimbolide, bartogenic acid, cannabidiol, and curcumin), and flavonoids (quercetin, resveratrol, kaempferol, chebulanin, ellagic acid, rosmarinic acid, gallic acid, chlorogenic acid, ferulic acid, and brazilin). These isolates act through numerous pharmacological mechanisms such as inhibiting cytokines, chemokines, or matrix metalloproteinase, etc., to demonstrate AA activity. Animal models utilized for assessing the AA properties of these isolates, including adjuvant-induced arthritis mouse models, are also discussed. Furthermore, nanotechnology-based approaches to deliver these isolates are also reviewed, which have shown improved therapeutic efficacy of isolated compounds.

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Section: Chebulaninmentioning

confidence: 87%

Antiarthritic Activities of Herbal Isolates: A Comprehensive Review

Jain¹,

Vaidya

Gupta

et al. 2021

Coatings

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“…Chebulanin also reduces IL-6 and TNF-α levels and interferes with phosphorylation of MAPK p38 and JNK in the CIA model [67].…”

Section: Impact Of Herbal Medicine On Ra Pathwaysmentioning

confidence: 88%

“…Examples of pure compounds include the polyphenols chebulagic acid and chebulanin isolated from Terminalia chebula , which have been shown to inhibit the MAPK pathway in lipopolysaccharide (LPS)‐induced RAW 264.7 macrophages. Chebulanin also reduces IL‐6 and TNF‐α levels and interferes with phosphorylation of MAPK p38 and JNK in the CIA model [67].…”

Section: Impact Of Herbal Medicine On Ra Pathwaysmentioning

confidence: 99%

Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis

et al. 2022

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Chinese medicine has a long tradition of use against rheumatoid arthritis (RA). The formulations are based on combinations of typically 5-10 plants, which are usually boiled and administered as a decoction or tea. There are few clinical trials performed so the clinical evidence is sparse. One fundamental of traditional medicine is to prevent disease. RA is an autoimmune, inflammatory and chronic disease that primarily affects the joints of 0.5%-1% of the population. In two out of three of the cases, the patients are characterised by the presence of autoantibodies such as the rheumatoid factor and the more disease-specific autoantibody against citrullinated proteins, so-called 'ACPA' (anticitrullinated protein/peptide antibodies). ACPA positivity is also strongly associated with specific variations in the HLA-DRB1 gene, the shared epitope alleles. Together with smoking, these factors account for the major risks of developing RA. In this review, we will summarise the background using certain plant-based formulations based on Chinese traditional medicine for the treatment and prevention of RA and the strategy we have taken to explore the mechanisms of action. We also summarise the major pathophysiological pathways related to RA and how these could be analysed. Finally, we summarise our ideas on how a clinical trial using Chinese herbal medicine to prevent RA could be conducted.

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“…Furthermore, modulation in phosphorylation of c‐Jun N‐terminal kinases (JNK), p38, and extracellular signal receptor kinase (ERK) added to the alleviation in FLS migration and invasion in RA (Pan et al, 2018). Similarly, myricetin, a flavonol converted to the prodrug, myricetin‐pentadione displayed in vitro anti‐inflammatory and antioxidant activity in lipopolysaccharide (LPS) induce RAW264.7 cell and in vivo (45 mg/kg) in AIA rats (Liu, Han, et al, 2020; Liu, Liu, et al, 2020). Apigenin is naturally extracted from fruits and vegetables and was used to treat FLS in the CIA mouse model (20 mg/kg) for 50 days.…”

Section: Pharmacotherapy Of Polyphenols For Treatment Of Rheumatoid A...mentioning

confidence: 99%

“…A flavanone, naringin administered orally (150 mg/kg) for 20 days in the CIA mice model attenuated RA progression by reducing pannus formation, various inflammatory cytokines, and HMGB‐1 release from toll‐like receptors (TLRs) (Kawaguchi et al, 2011). Chebulanin, an active constituent extracted from fruit Terminalia chebula , belongs to subclass flavonol and its treatment (80 mg/kg) in the CIA mice model inhibited phosphorylation of p‐p38, p‐JNK, p‐ERK, p‐IκBα, and p‐p65 responsible for suppressing transcription and activation of MAPK and NF‐κB signaling pathways resulting in a reduction proinflammatory cytokines (Liu, Han, et al, 2020; Liu, Liu, et al, 2020).…”

Section: Pharmacotherapy Of Polyphenols For Treatment Of Rheumatoid A...mentioning

confidence: 99%

Dietary polyphenols for management of rheumatoid arthritis: Pharmacotherapy and novel delivery systems

Maity

Wairkar

2022

Phytotherapy Research

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Rheumatoid arthritis (RA) is a chronic, complex, systemic autoimmune disease causing chronic inflammation, swelling, and pain. It affects pulmonary and ocular physiology, gastrointestinal disturbance, skeletal disorders, and renal malfunctioning. Although conventional and biological drugs available to treat RA are potent and effective, they lead to life‐threatening side effects and patient discomfort. Hence, alternative therapies are explored for their treatment which is safe, effective, and economical. Herbal drugs are widely used as an alternative therapy and some medicinal plants, especially dietary polyphenols proved their efficacy in treating RA. Polyphenols are secondary metabolites of plants possessing several pharmacological actions. They exert anti‐inflammatory, immunomodulatory and anti‐rheumatoid activity by modulating tumor necrosis factor, mitogen‐activated protein kinase, nuclear factor kappa‐light‐chain‐enhancer of activated B cells, and c‐Jun N‐terminal kinases. Thus, polyphenols could be a promising option for the management of RA. Unfortunately, polyphenols suffer from poor bioavailability due to their physicochemical properties and incorporation into novel delivery systems such as liposomes, nanoparticles, nanoemulsions, micelles improved their oral bioavailability. This review article summarizes dietary polyphenols, their pharmacological actions and novel delivery systems for the treatment of RA. Nevertheless, the commercial translation of polyphenols could be only possible after establishing their safety profile and successful clinical trials.

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Chebulanin exerts its anti-inflammatory and anti-arthritic effects via inhibiting NF-κB and MAPK activation in collagen-induced arthritis mice

Cited by 16 publications

References 41 publications

Antiarthritic Activities of Herbal Isolates: A Comprehensive Review

Antiarthritic Activities of Herbal Isolates: A Comprehensive Review

Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis

Dietary polyphenols for management of rheumatoid arthritis: Pharmacotherapy and novel delivery systems

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