Cheilitis: A cross‐sectional study—multiple factors involved in the aetiology and clinical features

Abstract

ObjectiveSince the aetiologies of cheilitis are broad and overlapping, the purpose of this cross‐sectional clinical study was to examine the multiple factors involved in aetiology and the disease’s clinical features.Subjects and MethodsWe analysed cheilitis prevalence, demography, clinical features, patients’ habits, psychological stress, systemic diseases, vitamin B9, B12 and iron serum levels and allergy test results in a total of 130 subjects with cheilitis, plus 22 healthy subjects.ResultsThe most common cheilitis types were: cheilitis simplex and eczematous cheilitis (28.5%); herpetic cheilitis (16.9%); and exfoliative and angular cheilitis (7.7%). Concerning bad habits, there was a significant association/connection between self‐reported saliva at the corners of the mouth and angular cheilitis, and between lip licking/biting and exfoliative cheilitis. Common associated conditions were skin diseases (56.5%) and atopy (84%). Vitamin B9 and B12 serum and iron values were mostly within the normal reference range. The patients suffering from herpetic cheilitis had significantly higher psychological/mental stress levels than the control group.ConclusionTo our knowledge, this is the first study of cheilitis patients that has simultaneously analysed aetiological factors, characteristics of the disease and diagnostic parameters.

Analysis of clinical presentations, lip transepidermal water loss and associated dermatological conditions in patients with chronic cheilitis

“…Likewise, previous studies demonstrated that dryness was correlated well with the severity of AD and ACD 12 , 13 as a result of significant decrease in the skin barrier function 14 , which further highlight the close relationship between CC and allergic dermatologic disease. In agreement with this, a recent cross-sectional study which examined the multiple factors involved in the aetiology of CC showed that of the systemic diseases recorded among CC patients, skin diseases were noticed most frequently although the type of skin disease was not described in detail 15 . Another study, which investigated the prevalence of hypersensitivity in cheilitis patients demonstrated increased serum total IgE level and positive food-specific IgG in cheilitis patients compared to the healthy control 16 .…”

Perceived Stress, Salivary Cortisol, and Temperament Traits among Students of Dental Medicine: A Prospective and Interventional Study

“…Understanding the impact of AS on the organism and the complex relationship of stress-induced interactions between psychological and neuroimmunological factors can help identify students who are prone to AS. If they can be identified early on in their studies, they can be introduced to healthy coping methods before the possible onset of PNE changes that contribute to the development of stress-associated conditions (e.g., cardiovascular, autoimmune, and other diseases) [81][82][83][84]. According to the literature data so far, this population is susceptible to stress even after graduation, and therefore it is important to educate them on how to reduce the impact of stress on the body [21].…”

The Impact of Vitamin Deficiencies on Oral Manifestations in Children

“…These findings underscore Research by Khan et al [102] and Liu et al [103] highlighted the prevalence of haematinic deficiencies in patients with RAS, with significant reductions observed in serum folic acid and B12 levels. Consequently, inflammation of the lips and perioral skin can often be linked to nutritional deficiencies, including B12 and sideropenic anemia, which are implicated in the etiology of exfoliative cheilitis [104,105]. These findings underscore the importance of evaluating vitamin and mineral status in patients presenting with inflammation of the lips, perioral skin, or oral cavity, particularly in persistent cases.…”