Chemerin, Inflammatory, and Nitrooxidative Stress Marker Changes Six Months after Sleeve Gastrectomy

Abstract

Background Chemerin is a chemokine known to be increased in morbidly obese (MO) patients and correlated with markers of inflammation and nitrooxidative stress. We aimed to evaluate the changes of serum chemerin six months after laparoscopic sleeve gastrectomy (SG) and to asses if these changes are accompanied by variations of inflammatory and nitrooxidative stress markers. Material and Methods We investigated the levels of chemerin, high-sensitive C-reactive protein (hsCRP), tumor necrosis factor alpha (TNF-α), nitrite and nitrate (NOx), total oxidant status (TOS), total antioxidant response (TAR), and oxidative stress index (OSI) in a group of 24 MO patients submitted to SG before and six months after surgery. The MO group was compared with 20 controls. Results hsCRP (p < 0.001), NOx (p < 0.001), TOS (p < 0.001), TAR (p = 0.007), and OSI (p = 0.001) were significantly different between the two groups. Six months after surgery, we noticed significant changes (42.28% decrease) of hsCRP (p = 0.044) and OSI (p = 0.041) (31.81% decrease), while no significant changes were observed for chemerin (p = 0.605), TNF-α (p = 0.287), NOx (p = 0.137), TOS (p = 0.158), and TAR (p = 0.563). Conclusions Our study showed no significant changes of chemerin, and except for hsCRP and OSI, no other inflammatory and nitrooxidative stress markers changed six months after surgery.

Temporal effects of laparoscopic sleeve gastrectomy on adipokines, inflammation, and oxidative stress in patients with impaired glucose homeostasis

“…Of interest we observed no significant correlations between the changes in weight and BMI with inflammatory cytokines . This observation is consistent with the findings of Catoi et al [18] . We did observe correlations between the Δ values for HOMA-%S and leptin (r=-0.37, P=0.03) and CRP (r=-0.48, P=0.006).…”

“…With respect to plasma markers of oxidative stress, controversy exists within the available literature. Catoi et al, observed months after LSG [18] . Banazadeh et al, observed a significant reduction in prooxidant antioxidant balance (PAB), 6 months after RYGB [19] .…”

Circulating Chemerin Levels, Anthropometric Indices and Metabolic Profile in Morbid Obesity

“…Similar to other studies [8][9][17][18][19], chemerin levels were significantly higher in obese patients compared to the non-obese group (11.56 (10.39-13.10) vs 9.10 (8.13-10.60) ng/mL, p = 0.0001). However, in our studied obese group chemerin was significantly lower compared to other reported series [8,20,21], possibly related to the status of metabolic health. Adiponectin levels were also significantly different between the two samples (18.05 ± 1.55 vs 16.36 ± 1.49 ng/mL, p = 0.0003).…”

“…In our study circulating chemerin was not correlated with BMI (r =0.25, p =0.08) as other reports demonstrate in obesity [8-10, 12, 19, 26, 28]. On the other hand, the reported data in morbid obesity are controversial, mainly based on results after bariatric surgery [8,20,21,29]. According to other clinical studies [9][10][11][12]19] our results demonstrate the correlation between circulating chemerin and waist circumference (r =0.37, p = 0.012) and WHR (r = 0.36, p = 0.012).…”

Temporal Effects of Bariatric Surgery on Adipokines, Inflammation and Oxidative Stress in Subjects with Impaired Glucose Homeostasis at 4 Years of Follow-up

“…With respect to oxidative stress, there are conflicting reports in the available literature. Catoi et al observed no change in global measures of oxidative stress; nitrite and nitrate (NOx), total oxidant status (TOS), total antioxidant response (TAR), and oxidative stress index (OSI), 6 months after sleeve gastrectomy (SG) [5]. However, Cabrera et al demonstrated that plasma level of glutathione (GSH) and total radical antioxidant parameter (TRAP) was increased and plasm a l e v e l s o f s u p e r o x i d e d i s m u t a s e ( S O D ) a n d malondialdehyde (MDA) were decreased in 20 patients with obesity 12 months after Roux-en-Y Gastric Bypass (RYGB) [6].…”