Chemerin Relationship with Glucose and Lipid Metabolism in Clinically Asymptomatic Patients

Skuja, Ilze; Stukena, Inga; Lejnieks, Aivars

doi:10.4172/2327-4972.1000193

Cited by 2 publications

(4 citation statements)

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“…In humans, chemerin is known to regulate the cell differentiation from preadipocytes to adipocytes (6). Consequently, many studies have observed positive associations of circulating chemerin concentrations with obesity (6, 7, 8) and associated metabolic diseases (6, 9). Besides their expression in adipose tissue, chemerin and CMKLR1 have been found to be expressed in various other human tissues and cell populations, including the liver (6), Kupffer cells (10) and primary human hepatocytes (10).…”

Section: Introductionmentioning

confidence: 99%

“…Based on these findings, an association between circulating chemerin concentrations and hepatic steatosis is assumed. However, up to now, only few clinical studies have focused on the link between circulating chemerin concentrations and liver function, and these studies have reported conflicting findings (7, 8, 11, 12, 13, 14, 15). Some studies have detected higher circulating chemerin concentrations in NAFLD patients than in healthy controls (11, 13, 14), whereas others did not confirm this finding (12, 15).…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have detected higher circulating chemerin concentrations in NAFLD patients than in healthy controls (11, 13, 14), whereas others did not confirm this finding (12, 15). Likewise, studies dealing with the relation between serum chemerin concentrations and different liver enzymes, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) or gamma-glutamyltransferase (GGT), have observed conflicting results (8, 15).…”

Section: Introductionmentioning

confidence: 99%

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Associations of circulating chemerin and adiponectin concentrations with hepatic steatosis

Levin

Völzke

Lerch

et al. 2019

Endocrine Connections

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Objective Chemerin and adiponectin are adipokines assumed to be involved in the development of metabolic syndrome-related phenotypes like hepatic steatosis. We aimed to evaluate the associations of circulating chemerin and adiponectin concentrations with liver enzymes, liver fat content, and hepatic steatosis in the general population. Methods Data of 3951 subjects from the population-based Study of Health in Pomerania (SHIP-TREND) were used. Hepatic steatosis was assumed when either a hyperechogenic liver (assessed via ultrasound) or a magnetic resonance imaging (MRI)-quantified liver fat content >5% was present. Adjusted sex-specific quantile and logistic regression models were applied to analyze the associations of chemerin and adiponectin with liver enzymes, liver fat content and hepatic steatosis. Results The observed associations of chemerin and adiponectin with liver enzymes were very divergent depending on sex, fasting status and the specific enzyme. More consistent results were seen in the analyses of these adipokines in relation to MRI-quantified liver fat content. Here, we observed inverse associations to adiponectin in both sexes as well as a positive (men) or U-shaped (women) association to chemerin. Similarly, the MRI-based definition of hepatic steatosis revealed strongly consistent results: in both sexes, high chemerin concentrations were associated with higher odds of hepatic steatosis, whereas high adiponectin concentrations were associated with lower odds. Conclusion Our results suggest a role of these adipokines in the pathogenesis of hepatic steatosis independent of metabolic or inflammatory disorders. However, experimental studies are needed to further clarify the underlying mechanisms and the inter-play between adipokine concentrations and hepatic steatosis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations of circulating chemerin and adiponectin concentrations with hepatic steatosis

Levin

Völzke

Lerch

et al. 2019

Endocrine Connections

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“…It has been shown that chemerin in 3T3-L1 adipocytes improves insulin stimulated glucose uptake through the insulin signaling. This suggested that chemerin may regulate insulin sensitivity of adipose tissue (26) , In that case with increase in chemerin concentration, the concentration of insulin should decline, but the experiment showed, FSI were positively correlated with serum chemerin.…”

Section: Discussionmentioning

confidence: 90%

Role of Visfatin Chemerin with Type Two Diabetes Mellitus

Mohammed Sulaiman,

Nafi Salih,

Abdullah Alazzawy

2019

Kufa Jour. Bio.

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A cross-sectional study was carried out in Kirkuk city from December 2016 to March 2017. The number of diabetic patients understudy were 180 whose ages were between 21-81 years old. These patients admitted to Kirkuk General Hospital and primary health care centers of Kirkuk first health care sector. The control group who were matched to the diabetic patients studied, included 90 healthy blood donors. Blood was collected for assessment of HbA1c test, blood glucose level, visfatin and chemerin levels. The study showed that the highest mean level of visfatin was found in diabetic patients comparing with healthy control ( 6.22±2.17 v.s. 3.54±1.91 ng/ml). The study showed that the highest mean level of chemerin was found in diabetic patients comparing with healthy control (146.13±12.67 v.s. 92.17±8.01 ng/ml). The study showed that the highest mean level of visfatin was found in diabetic patients who have elevated level of glucose and HbA1c (5.75±3.81 and 5.91±3.67 ng/ml) respectively, as compared with patients with normal level of glucose and HbA1c (4.61±2.99 and 3.95±2.12 ng/ml) respectively (P: ≤0.05). The study showed that the highest mean level of visfatin was found in diabetic patients who have elevated level of glucose and HbA1c (148.9±25.7 and 158.6±23.5 ng/ml) respectively, as compared with patients with normal level of glucose and HbA1c (111.5±14.6 and 105.1±15.7 ng/ml) respectively (P: ≤0.05), Table 5 and 6.

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Chemerin Relationship with Glucose and Lipid Metabolism in Clinically Asymptomatic Patients

Cited by 2 publications

References 0 publications

Associations of circulating chemerin and adiponectin concentrations with hepatic steatosis

Associations of circulating chemerin and adiponectin concentrations with hepatic steatosis

Role of Visfatin Chemerin with Type Two Diabetes Mellitus

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