Chemical analysis of a new (1→3)-, (1→6)-branched glucan from an edible mushroom, Pleurotus florida

Rout, Dilip; Mondal, Soumitra; Chakraborty, Ipsita; Pramanik, Malay; Islam, Syed S.

doi:10.1016/j.carres.2005.08.006

Cited by 132 publications

(51 citation statements)

References 33 publications

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“…The like of these bioactives are polysaccharides [22]; polysaccharopeptides [25]; polysaccharide-proteins [18]; functional proteins such as Pleuron [28], glycoprotein [27], ubiquinone-9 [49], nebrodeolysin [50], ubiquitin-like peptide [26]; glucans [23]; proteoglycans [24] and lectin [51]. Some of these compounds act as immunotherapy by influencing the production of cytokine in human peripheral blood mononuclear cells (hPBMC), which may include mitogenicity, stimulation and activation of immune effector cells [15].…”

Section: Bioactive Compounds With Immunotherapeutic Potential From Plmentioning

confidence: 99%

“…Pleurotus species are good source of immunomodulators, the substances considered as "host defense potentiators" (HDPs) as judged by their immuno-stimulating properties [20]. Several molecules that are able to augment or complement a desired immune response have been isolated from Pleurotus spp., such as: water-soluble polysaccharides from P. citrinopileatus fermentation broth [22]; glucans from P. florida fruiting bodies [23]; proteoglycans, polysaccharides and polysaccharopeptides from P. ostreatus mycelia [24,20,25]; a ubiquitin-like peptide from P. sajorcaju [26]; a glycoprotein from P. citrinopileatus [27]; a Pleurone from P. eryngii [28] and DNA from P. ostreatus fruiting bodies [29]. These compounds stimulate different cell populations of the immune system, for instance, macrophages, Natural killer (NK) cells, T-cells, and also modulate cytokine system [21].…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients

Oloke¹

2015

IJI

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Abstract:In the recent years, mushrooms are distinguished as important natural resources of immunotherapy which can be used as immunomodulating and immunostimulating in the management of some immunodeficiency diseases such as cancer, tumour, HIV, tuberculosis etc. Mushroom of the genus Pleurotus are good sources of several bioactive compounds which are able to augment or complement a desired immune response. Such bioactive compounds are polysaccharopeptides, polysaccharide-proteins, functional proteins (ubiquinone-9, nebrodeolysin, ubiquitin-like peptide and glycoprotein), glucans, proteoglycans and many others. Most of these bioactive compounds follow the immunomodulatory pathway mechanism of polysaccharide (β-glucan) from mushrooms by stimulating activities for both innate and adaptive immune systems. They proliferate and activate innate immune system components such as natural killer (NK) cells, neutrophils, and macrophages, and stimulate cytokines expression and secretion. These cytokines in turn activate adaptive immunity through the promotion of Bcells for antibodies production and stimulation of T-cell differentiation to T helper (Th1 and Th2) cells, which mediate cell and humoral immunities, respectively. In this review, the immunotherapeutic potential of oyster mushroom in relation to bioactive compounds produced is shown and this suggests that the oyster mushrooms are one of the most important natural products and functional foods.

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Section: Bioactive Compounds With Immunotherapeutic Potential From Plmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients

Oloke¹

2015

IJI

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“…It has also been reported that -(1,3) glucans from Pleurotus florida and Collybia dryophila are well-known macrophage activators in nature. 31,32) Schepetkin et al 33) have observed a relationship between M w and NO production from murine macrophage cells in a study of other mushroom extracts. These authors found that extracts with higher M w induced a greater production of NO from murine macrophage J774.A1 cells.…”

Section: Bioactivities Of the Crude Extract And Fractionsmentioning

confidence: 99%

Molecular Characteristics of Water-Soluble Extracts fromHypsizigus marmoreusand Theirin VitroGrowth Inhibition of Various Cancer Cell Lines and Immunomodulatory Function in Raw 264.7 Cells

Bao

You

2011

Bioscience, Biotechnology, and Biochemistry

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“…The absorption of RGP1 and RGP2-1 at 1154.83/1152.59 cm −1 , 1080.20/1079.00 cm −1 , and 1023.75/1023.53 cm −1 indicated the bending vibrational modes of C-O stretching in the pyranose form. In addition, the peak at 859.08 cm −1 resulted from the presence ofglycosidic bounds [28,29].…”

Section: Preliminary Characterization Of Rgp1 and Rgp2-1mentioning

confidence: 99%

Physicochemical Characterization of Polysaccharides with Macrophage Immunomodulatory Activities Isolated from Red Ginseng (Panax ginseng C. A. Meyer)

Liang

Wang

Peng

et al. 2017

Journal of Chemistry

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In this study, four polysaccharide fractions designated as RGP1, RGP2, RGP3, and RGP4 were isolated from red ginseng by DEAE-52 cellulose chromatography, and their macrophage immunomodulatory activities were investigated. The results revealed that the proliferation, NO production, and neutral red phagocytosis of RAW 264.7 macrophage cells in groups treated with RGP1 and RGP2 in vitro were increased significantly compared to RGP3 and RGP4. In addition, the level of TNF-in RAW 264.7 cells was significantly increased in RGP1 and RGP2 groups. All the results consistently indicated that polysaccharide fractions RGP1 and RGP2 had strong macrophage immunomodulatory activities. Furthermore, RGP1 and RGP2 were purified by Sephadex G-100 column and RGP2 was further fractionated into a homogeneous fraction RGP2-1, with the molecular weight of 2.16 × 10 4 Da. The analysis of monosaccharide composition revealed that RGP1 was composed of arabinose, glucose, and galactose with a relative molecular ratio of 0.02 : 0.88 : 0.10. RGP2-1 was composed of rhamnose, arabinose, glucose, and galactose with a relative molecular ratio of 0.02 : 0.10 : 0.77 : 0.11. These results provided evidences that the neutral polysaccharide fractions RGP1 and RGP2 possessed significant immunomodulatory activity and could be explored as a promising natural immunomodulating agent applied in functional foods or medicines.

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Chemical analysis of a new (1→3)-, (1→6)-branched glucan from an edible mushroom, Pleurotus florida

Cited by 132 publications

References 33 publications

Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients

Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients

Molecular Characteristics of Water-Soluble Extracts fromHypsizigus marmoreusand Theirin VitroGrowth Inhibition of Various Cancer Cell Lines and Immunomodulatory Function in Raw 264.7 Cells

Physicochemical Characterization of Polysaccharides with Macrophage Immunomodulatory Activities Isolated from Red Ginseng (Panax ginseng C. A. Meyer)

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