Chemical and antiplatelet aggregative investigation of the leaves of Clausena excavata

Wu, Tong; Shiow-Chyn, Huang; Jeng-Shiow, Lai; Che-Ming, Teng; Ko, Feng‐Nien; Kuoh, Chang‐Sheng

doi:10.1016/s0031-9422(00)95013-1

Cited by 47 publications

(4 citation statements)

References 13 publications

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“…[3] The leaves are particularly used in traditional medicine to cure cold, abdominal pain, malaria, [5] dysentery, and antiplatelet aggregation. [6] The plant is also reported to have insecticidal, tonic, and vermifugal properties. [6] C. excavata has been reported to contain carbozole alkaloids, coumarins, limnoids, [4] etc.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antioxidant activity of the methanolic leaf extract of Clausena excavata Burm. f.(Rutaceae) using the lipid peroxidation model

Guntupalli

Kumar

et al. 2012

Pharmacognosy Journal

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Clausena excavata Burm. f.(Rutaceae) has long been associated with medicinal benefits in folk medicine, particularly in the treatment of cancer and its related disorders in the eastern region of Thailand. The present study evaluates the antioxidant activity of the methanolic leaf extract of C. excavata using the lipid peroxidation model. The results indicated that the methanolic leaf extract showed marked antioxidant activity (IC 50 = 201.3 µg/ml), whereas the aqueous leaf extract showed moderate antioxidant activity (IC 50 = 450.6 µg/ml). In conclusion, the antioxidant activity of the methanolic leaf extract of C. excavata was comparable with that of propyl gallate, which is used as a standard drug, thus confirming that it might be a good source of antioxidants. The extended degree of antioxidant activity could be attributable to the presence of flavonols, gallic acid, and angelicin, which are known to be antioxidants.

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Section: Introductionmentioning

confidence: 99%

Evaluation of antioxidant activity of the methanolic leaf extract of Clausena excavata Burm. f.(Rutaceae) using the lipid peroxidation model

Guntupalli

Kumar

et al. 2012

Pharmacognosy Journal

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“…Last, it supports the carbon-hydrogen activation and the deprotonation steps. The utility of this protocol was tested on the total synthesis of clausine L, 183 which was produced in 78% yield under optimised conditions. Using a conceptually related protocol, Miranda and co-workers synthesised anti-cancer agent Isoellipticine.…”

Section: Carbon-carbon Bond Formationmentioning

confidence: 99%

Trends in carbazole synthesis – an update (2013–2023)

Allen,

Natho

2023

Org. Biomol. Chem.

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“…3 The leaves are particularly used in traditional medicine to cure cold, abdominal pain, malaria, 5 dysentery, and anti-platelet aggregation. 6 The plant is also reported to have insecticidal, tonic, and vermifugal properties. 6 C. excavata has been reported to contain carbozole alkaloids, coumarins, limnoids, 4 etc.…”

Section: Introductionmentioning

confidence: 99%

“…6 The plant is also reported to have insecticidal, tonic, and vermifugal properties. 6 C. excavata has been reported to contain carbozole alkaloids, coumarins, limnoids, 4 etc. The sap of the leaves is applied on the affected area to treat all kinds of muscular pain.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Biological Activity and Comparison of UPLC and RP-HPLC Chromatographic Profiles of Clausena excavata Burm.F.

Guntupalli¹,

Alavala²,

Maddi³

2017

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Clausena excavata Burm. F. (Rutaceae) has long been associated with medicinal benefits in folk medicine, particularly in the treatment of cancer and its related disorders in the eastern region of Thailand. In the the present study Ultra Pressure Liquid Chromatography (UPLC) analysis of methanolic leaf extracts of Clausena excavata were carried out using short (5 cm × 2.1 mm I.D.) columns, containing 2 µm particles at very high pressures (up to 16000 psi) to obtain high efficiency separations in very short run times. The results indicate that UPLC provided better resolution compared to routine RP-HPLC. The analysis time was drastically reduced (4 min.) which is proved to be a faster and more economical analytical tool than RP-HPLC. In addition to that, the present study also evaluates anti-fungal activity against dermatophytes Trichophyton rubrum and Trichophyton mentographytes by using an agar incorporation technique. The anti-fungal activity may be due to the presence of Angelecin and gallic acid in the plant extract.

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Chemical and antiplatelet aggregative investigation of the leaves of Clausena excavata

Cited by 47 publications

References 13 publications

Evaluation of antioxidant activity of the methanolic leaf extract of Clausena excavata Burm. f.(Rutaceae) using the lipid peroxidation model

Evaluation of antioxidant activity of the methanolic leaf extract of Clausena excavata Burm. f.(Rutaceae) using the lipid peroxidation model

Trends in carbazole synthesis – an update (2013–2023)

Assessment of Biological Activity and Comparison of UPLC and RP-HPLC Chromatographic Profiles of Clausena excavata Burm.F.

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