Chemical and genetic similarity and diversity of Ligularia anoleuca and L. fischeri collected in the Hengduan Mountains of China

Shimizu, Anna; Suzuki, Yurika; Hanai, Ryo; Okamoto, Yasuko; Tori, Motoo; Gong, Xun; Kuroda, Chiaki

doi:10.1016/j.phytochem.2014.03.019

Cited by 11 publications

(13 citation statements)

References 27 publications

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“…LFT is mainly used to treat coughs, ulcers, and tuberculosis as a clinical therapeutic agent [2]. The chemical constituents and pharmacological effects of LFT have been studied previously [3][4][5][6][7]. The plant roots are rich in aroma and volatile oils.…”

Section: Introductionmentioning

confidence: 99%

Molecular mechanism underlying the anti-inflammatory effects of volatile components of Ligularia fischeri (Ledeb) Turcz based on network pharmacology

Huang

Gao

Feng

et al. 2020

BMC Complement Med Ther

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Background: Ligularia fischeri (Ledeb) Turcz (LFT) is a well-known expectorant and active anti-inflammatory agent in Chinese traditional medicine. LFT's expectorant effect is closely related to its anti-inflammatory effects. This study aimed to evaluate the differential composition and anti-inflammatory mechanisms of the volatile components in LFT from different production areas. Method: Headspace solid-phase microextraction-gas chromatography-mass spectrometry analysis of volatile components, as well as chemometric methods, including similarity analysis, hierarchical clustering analysis, and principal component analysis, were performed to identify LFT produced in different areas. The molecular mechanism underlying the anti-inflammatory effects of these components was determined by network pharmacology analysis. Results: We observed significant differences in the chemical constituents and percentage contents in samples with different origins. Eighteen volatile components were identified in four different producing areas, among which the highest content of olefinic components was the main component of the aroma of LFT. The mechanisms of these pharmacological effects involved multiple targets and pathways. Twenty-seven potential target proteins and 65 signaling pathways were screened, and a "component-target-disease" interaction network map was constructed. The volatile components of the LFT function mainly by inhibiting the production of inflammatory factors. Conclusion: This study provides a theoretical framework for further development and application of LFT used in traditional Chinese medicine.

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Section: Introductionmentioning

confidence: 99%

Molecular mechanism underlying the anti-inflammatory effects of volatile components of Ligularia fischeri (Ledeb) Turcz based on network pharmacology

Huang

Gao

Feng

et al. 2020

BMC Complement Med Ther

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“…In China, Ligularia species are mainly distributed in mountainous areas in the southwest ( Liu and Illarionova, 1989 ) and more than 30 Ligularia species have long been used in folk medicine ( Wang, 2007 ). The roots, stems, leaves, and flowers of them contain various chemical compounds, such as sesquiterpenes ( Wang, 2007 ; Shimizu et al, 2014 ; Saito et al, 2017 ) and alkaloids ( Asada et al, 1981 ; Feng, 2016 ). They are used as herbal medicines for the treatment of bronchitis, coughing, pulmonary tuberculosis, and hemoptysis.…”

Section: Introductionmentioning

confidence: 99%

Identification of Ligularia Herbs Using the Complete Chloroplast Genome as a Super-Barcode

et al. 2018

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More than 30 Ligularia Cass. (Asteraceae) species have long been used in folk medicine in China. Morphological features and common DNA regions are both not ideal to identify Ligularia species. As some Ligularia species contain pyrrolizidine alkaloids, which are hazardous to human and animal health and are involved in metabolic toxification in the liver, it is important to find a better way to distinguish these species. Here, we report complete chloroplast (CP) genomes of six Ligularia species, L. intermedia, L. jaluensis, L. mongolica, L. hodgsonii, L. veitchiana, and L. fischeri, obtained through high-throughput Illumina sequencing technology. These CP genomes showed typical circular tetramerous structure and their sizes range from 151,118 to 151,253 bp. The GC content of each CP genome is 37.5%. Every CP genome contains 134 genes, including 87 protein-coding genes, 37 tRNA genes, eight rRNA genes, and two pseudogenes (ycf1 and rps19). From the mVISTA, there were no potential coding or non-coding regions to distinguish these six Ligularia species, but the maximum likelihood tree of the six Ligularia species and other related species showed that the whole CP genome can be used as a super-barcode to identify these six Ligularia species. This study provides invaluable data for species identification, allowing for future studies on phylogenetic evolution and safe medical applications of Ligularia.

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“…Some of them demonstrated cytotoxic, antibacterial, antiviral, and anti‐inflammatory activities . Typical and diversified, eremophilanes can be regarded as the chemotaxonomic markers of this genus . Aside from Ligularia , eremophilanes are also present in other genera of the same family Compositae, Senecio , Cacalia , and Petasites , in particular.…”

Section: Introductionmentioning

confidence: 99%

Eremophilane Sesquiterpenes from the Genus Ligularia

Liao

Liu³

et al. 2016

Chemistry & Biodiversity

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Chemical and genetic similarity and diversity of Ligularia anoleuca and L. fischeri collected in the Hengduan Mountains of China

Cited by 11 publications

References 27 publications

Molecular mechanism underlying the anti-inflammatory effects of volatile components of Ligularia fischeri (Ledeb) Turcz based on network pharmacology

Molecular mechanism underlying the anti-inflammatory effects of volatile components of Ligularia fischeri (Ledeb) Turcz based on network pharmacology

Identification of Ligularia Herbs Using the Complete Chloroplast Genome as a Super-Barcode

Eremophilane Sesquiterpenes from the Genus Ligularia

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