Chemical and mechanical influence of root canal irrigation on biofilm removal from lateral morphological features of simulated root canals, dentine discs and dentinal tubules
Abstract:Chemical and mechanical influence of root canal irrigation on biofilm removal from lateral morphological features of simulated root canals, dentine discs and dentinal tubules.
“…NaOCl removed significantly more biofilm from the lateral canal‐ and isthmus‐like structure than the inert active control. This is in contrast to an earlier study using the same model (Pereira et al 2020b). However, in that study, irrigant exposure time was 30 s and the flow was constant.…”
Section: Discussioncontrasting
confidence: 99%
“…active control. This is in contrast to an earlier study using the same model (Pereira et al 2020b). However, in that study, irrigant exposure time was 30 s and the flow was constant.…”
Section: Discussionmentioning
confidence: 61%
“…Higher flow rate removed significantly more biofilm only from the isthmus‐like structure. Earlier studies using the same root canal model also demonstrated that flow rate had a higher impact on biofilm removal from an isthmus‐like structure than a lateral canal‐like structure ((Pereira et al 2020a,b) Macedo et al . 2014b).…”
Section: Discussionmentioning
confidence: 87%
“…It has also been demonstrated that lower concentration NaOCl solutions have a significantly less effective reaction rate compared to high concentration solutions, even after multiple refreshments of the former (Macedo et al 2014a). Moreover, a constant flow of a 2% NaOCl using syringe irrigation did not remove more biofilm from lateral morphological features than an inert control solution (Pereira et al 2020b). In addition, within 30 s of exposure, increasing NaOCl concentration did not significantly improve the removal of biofilm from lateral morphological features (Pereira et al 2020a).…”
Section: Introductionmentioning
confidence: 97%
“…2014a). Moreover, a constant flow of a 2% NaOCl using syringe irrigation did not remove more biofilm from lateral morphological features than an inert control solution (Pereira et al 2020b ). In addition, within 30 s of exposure, increasing NaOCl concentration did not significantly improve the removal of biofilm from lateral morphological features (Pereira et al 2020a).…”
Pereira TC, Dijkstra RJB, Petridis X, van der Meer WJ, Sharma P, de Andrade FB, van der Sluis LWM. The influence of time and irrigant refreshment on biofilm removal from lateral morphological features of simulated root canals.
“…NaOCl removed significantly more biofilm from the lateral canal‐ and isthmus‐like structure than the inert active control. This is in contrast to an earlier study using the same model (Pereira et al 2020b). However, in that study, irrigant exposure time was 30 s and the flow was constant.…”
Section: Discussioncontrasting
confidence: 99%
“…active control. This is in contrast to an earlier study using the same model (Pereira et al 2020b). However, in that study, irrigant exposure time was 30 s and the flow was constant.…”
Section: Discussionmentioning
confidence: 61%
“…Higher flow rate removed significantly more biofilm only from the isthmus‐like structure. Earlier studies using the same root canal model also demonstrated that flow rate had a higher impact on biofilm removal from an isthmus‐like structure than a lateral canal‐like structure ((Pereira et al 2020a,b) Macedo et al . 2014b).…”
Section: Discussionmentioning
confidence: 87%
“…It has also been demonstrated that lower concentration NaOCl solutions have a significantly less effective reaction rate compared to high concentration solutions, even after multiple refreshments of the former (Macedo et al 2014a). Moreover, a constant flow of a 2% NaOCl using syringe irrigation did not remove more biofilm from lateral morphological features than an inert control solution (Pereira et al 2020b). In addition, within 30 s of exposure, increasing NaOCl concentration did not significantly improve the removal of biofilm from lateral morphological features (Pereira et al 2020a).…”
Section: Introductionmentioning
confidence: 97%
“…2014a). Moreover, a constant flow of a 2% NaOCl using syringe irrigation did not remove more biofilm from lateral morphological features than an inert control solution (Pereira et al 2020b ). In addition, within 30 s of exposure, increasing NaOCl concentration did not significantly improve the removal of biofilm from lateral morphological features (Pereira et al 2020a).…”
Pereira TC, Dijkstra RJB, Petridis X, van der Meer WJ, Sharma P, de Andrade FB, van der Sluis LWM. The influence of time and irrigant refreshment on biofilm removal from lateral morphological features of simulated root canals.
Candida albicans is a microorganism that causes root canal infections. However, it cannot be eliminated with conventional irrigation solutions. Recently, silver nanoparticles (AgNPs) have become popular for their superior antimicrobial effects. The purpose of this study was to evaluate the antifungal effect of AgNPs to C. albicans comparing with 5.25% sodium hypochlorite (NaOCl) and 2% chlorhexidine (CHX). Silver nanoparticles were synthesized by chemical reduction method. Minimum inhibitory concentration and minimum fungicidal concentration of AgNPs against C. albicans strain were determined according to microdilution method reported by Clinical Laboratory Standards Institute. C. albicans biofilm layer was formed on the dentin blocks for 10 days. The biofilm structure was observed by scanning electron microscopy. Statistical analysis was performed with one way analysis of variance analysis and group comparisons were performed with Tukey test. AgNPs showed the highest antifungal effect among the groups. 5.25% NaOCl showed the lowest antifungal effect among the groups. While the 2% CHX solution had a statistically lower antifungal effect than AgNPs, it was found to have a higher effect than NaOCl (p < .016). Nanoparticles present a wide research field as an alternative irrigation solution in root canal treatment. The antifungal effect of AgNPs against C. albicans was confirmed in this study. Further in vivo studies should evaluate the conditions of use and long‐term prognosis of AgNPs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.