Chemical and Physicochemical Characterization of Petrolatums Used in Eye Ointment Formulations

Abstract

Petrolatums from different manufacturers were characterized by viscosity measurements, oil number and ratio of low to high mol. wt components (capillary gas chromatography). Viscosity measurements and oil numbers of original materials did not correlate with the viscosity of the processed material in eye ointments. The ratio of high carbon number components to the low carbon number components was a reliable predictor for the viscosity of the formulation.

Perspectives on Physicochemical and In Vitro Profiling of Ophthalmic Ointments

“…Due to white soft paraffin being a mixture of different hydrocarbons as well as to the complexity of the petrolatum processing to obtain the finished products, it is extremely challenging to ensure the quality of this excipient and the related pharmaceutical products. Muynck et al [25] quantitatively analyzed the components in white soft paraffin using capillary gas chromatography. This methodology could potentially be used to ensure quality of white soft paraffin, and accordingly reduce the batch-to-batch variation of ophthalmic ointment products.…”

Excipient–Drug Interactions in Parenteral Formulations

“…Petrolatum is a commonly used ointment base for topical ophthalmic ointments. There are no known incompatibilities with petrolatum 36…”

Programa perceptivo-motor aplicado a habilidade nadar na fase de aperfeiçoamento

“…Estes indicadores estão relacionados à peiformance motora na natação e estes são amplamente utilizados nas pesquisas internacionais (Craig et al, 1979;Craig et ai., 1985;Grimston e Hay, 1986;Keskinen e Komi, 1993;Pelayo et ai., 1996;Pelayo et ai., 1997e Vilas Boas, 1998. Contrariamente, aumenta a percepção (epidérmica) quando esses materiais são retirados (Neiburger, 1992;De Muynck et al, 1993;Thompson e Lambert, 1995;Nelson e Mital, 1995;Woods et al, 1996;Knudsen e Menn, 1996;Phillips, Birch e Ribbans, 1997;Ogimoto e Ogawa, 1997;Brito e Araujo Júnior, 1999;Nilsson et al, 1999). performance de nado, encontra-se com baixa correlação entre a velocidade e a Fr no gênero feminino (r= 0,33; p > 0,05) e no masculino (r= 0,32; p > 0,05).…”