Chemical approaches to inhibitors of isoprenoid biosynthesis: targeting farnesyl and geranylgeranyl pyrophosphate synthases

Merino, Pedro; Maiuolo, Loredana; Delso, J. Ignacio; Algieri, Vincenzo; Nino, Antonio De; Tejero, Tomás

doi:10.1039/c6ra28316k

Cited by 20 publications

(14 citation statements)

References 139 publications

(124 reference statements)

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“…Schematic representations of the biosynthesis of: (a) isoprenoids, reproduced from Ref. [20] with permission from the Royal Society of Chemistry; (b) phenylpropanoids, reproduced from Ref. [21].…”

Section: Production Of Polymeric Fibres By Solution Electrospinningmentioning

confidence: 99%

“…The fabrication of defect-free electrospun fibres with the desired size and structure is achievable by a fine optimisation of all process parameters [32,33]. This includes control over the properties of [20] with permission from the Royal Society of Chemistry; (b) phenylpropanoids, reproduced from Ref. [21].…”

Section: Production Of Polymeric Fibres By Solution Electrospinningmentioning

confidence: 99%

“…Phenylpropanoids are secondary plant metabolites synthetized by the amino acid phenylalanine (primary metabolite) via the general phenylpropanoid pathway (Figure 1b) [19][20][21][22]. Their biosynthesis starts with the formation of cinnamic acid from phenylalanine by the action of phenylalanine ammonia-lyase (PAL).…”

Section: Introductionmentioning

confidence: 99%

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Electrospinning of Essential Oils

Mele

2020

Polymers

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The extensive and sometimes unregulated use of synthetic chemicals, such as drugs, preservatives, and pesticides, is posing big threats to global health, the environment, and food security. This has stimulated the research of new strategies to deal with bacterial infections in animals and humans and to eradicate pests. Plant extracts, particularly essential oils, have recently emerged as valid alternatives to synthetic drugs, due to their properties which include antibacterial, antifungal, anti-inflammatory, antioxidant, and insecticidal activity. This review discusses the current research on the use of electrospinning to encapsulate essential oils into polymeric nanofibres and achieve controlled release of these bioactive compounds, while protecting them from degradation. The works here analysed demonstrate that the electrospinning process is an effective strategy to preserve the properties of essential oils and create bioactive membranes for biomedical, pharmaceutical, and food packaging applications.

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Section: Production Of Polymeric Fibres By Solution Electrospinningmentioning

confidence: 99%

Section: Production Of Polymeric Fibres By Solution Electrospinningmentioning

confidence: 99%

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Electrospinning of Essential Oils

Mele

2020

Polymers

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“…Drugs based on a chelating agent able to sequestering a specific metal are not necessarily the best, but only the most common drugs. [7][8][9][10] Specificity and stability of the metalchelator complexes are extremely important in the choice of the most adequate chelating agent. Indeed, complexes stability is the first requirement to transform toxic metal ions in chelated species to be excreted.…”

Section: Introductionmentioning

confidence: 99%

Sequestering Ability of a Synthetic Chelating Agent towards Copper(II) and Iron(III): A Detailed Theoretical and Experimental Analysis

Ritacca

Malacaria

Algieri

et al. 2020

Chemistry An Asian Journal

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In the continuous effort to identify selective chelators towards bioavailable and toxic metal ions, the potential selectivity of a novel N,O chelating ligand, recently synthesized and claimed to be able to bind to Cu(II) ions forming stable complexes while leaving unaltered the level of essential metal ions, was scrutinized using a combined theoretical and experimental approach. A multistep synthetic procedure was used to synthesize the ligand, whose chelating properties along with the stability of the complexes formed binding Cu(II) and, for comparison, Fe(III) ions were evaluated using potentiometric measurements and UV-Vis spectroscopy. DFT analysis allowed to disclose the structural characteristics of the formed complexes. In the plethora of all the possible structures, a selection of the most reliable ones was achieved by means of a stringent comparison between experimental and simulated UV-Vis spectra. The outcomes of the present investigation demonstrate that the Cu(II) sequestering ability of the ligand is smaller than that towards Fe(III). The strategy used here should allow to check the propensity of ligands in selectively binding metal ions.

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“…Non-hydrolyzable analogues of inorganic pyrophosphate, i.e., derivatives of methylenediphosphonic acid, are used in biochemistry as a source of the inhibitors of the pyrophosphate-related enzymes and for the investigation of their reaction mechanisms (for review see [ 1 , 2 , 3 ]). Medronic and etidronic acids as well as their derivatives ( Figure 1 ), having high affinity to Ca 2+ ions in bones, are used for treatment of osteoporosis [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

On the Reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines: Unexpected Degradation of P-C-P Bridge

et al. 2017

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Derivatives of methylenediphosphonic acid possess wide spectra of biological activities and are used in enzymology as research tools as well as in practical medicine. Carbonyl diphosphonic acid is a promising starting building block for synthesis of functionally substituted methylenediphosphonates. Investigation of the interaction of carbonyl diphosphonic acid with hydroxylamine clearly demonstrates that it is impossible to isolate oxime within the pH range 2–12, while only cyanophosphonic and phosphoric acids are the products of the fast proceeding Beckmann-like fragmentation. In the case of O-alkylhydroxylamines, corresponding alcohols are found in the reaction mixtures in addition to cyanophosphonic and phosphoric acids. Therefore, two residues of phosphonic acid being attached to a carbonyl group provide new properties to this carbonyl group, making its oximes very unstable. This principally differs carbonyl diphosphonic acid from structurally related phosphonoglyoxalic acid and other α-ketophosphonates.

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Chemical approaches to inhibitors of isoprenoid biosynthesis: targeting farnesyl and geranylgeranyl pyrophosphate synthases

Abstract: The chemical synthesis of farnesyl and geranylgeranyl pyrophosphate synthase inhibitors are surveyed.

Cited by 20 publications

References 139 publications

Electrospinning of Essential Oils

Electrospinning of Essential Oils

Sequestering Ability of a Synthetic Chelating Agent towards Copper(II) and Iron(III): A Detailed Theoretical and Experimental Analysis

On the Reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines: Unexpected Degradation of P-C-P Bridge

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