Chemical Barrier Proteins in Human Body Fluids

Kalló, Gergő; Kumar, Ajneesh; Tőzsér, József; Csősz, Éva

doi:10.3390/biomedicines10071472

Cited by 4 publications

(2 citation statements)

References 180 publications

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“…Amylases and mucins are the most abundant proteins in the saliva [17], maintaining the homeostatic functions, but also parts of the chemical barrier. Owing to their hydrolytic activity, amylases can alter the biofilm formation of bacteria by cleaving the polysaccharide backbone of extracellular polymeric structures [97].…”

Section: Amylases and Mucins In The Chemical Barrier Of Patients With...mentioning

confidence: 99%

“…It is a very dilute body fluid composed of approximately 99% water with varying (0.7-2.4 µg/µL) protein concentrations [16], showing high variability depending on the age, sex, sample collection time, and health status of the oral cavity. Saliva contains more than 2700 proteins, and the most abundant proteins belong to the antimicrobial and immunomodulatory protein (AMP) family [17]. AMPs are elements of the innate immune system [18] and constitute the first line of defense in protecting the host from invading pathogens by creating a chemical barrier [19].…”

Section: Introductionmentioning

confidence: 99%

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Salivary Chemical Barrier Proteins in Oral Squamous Cell Carcinoma—Alterations in the Defense Mechanism of the Oral Cavity

Kalló,

Bertalan,

Márton

et al. 2023

IJMS

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Oral squamous cell carcinoma (OSCC) is one of the most frequent types of head and neck cancer. Despite the genetic and environmental risk factors, OSCC is also associated with microbial infections and/or dysbiosis. The secreted saliva serves as the chemical barrier of the oral cavity and, since OSCC can alter the protein composition of saliva, our aim was to analyze the effect of OSCC on the salivary chemical barrier proteins. Publicly available datasets regarding the analysis of salivary proteins from patients with OSCC and controls were collected and examined in order to identify differentially expressed chemical barrier proteins. Network analysis and gene ontology (GO) classification of the differentially expressed chemical barrier proteins were performed as well. One hundred and twenty-seven proteins showing different expression pattern between the OSCC and control groups were found. Protein–protein interaction networks of up- and down-regulated proteins were constructed and analyzed. The main hub proteins (IL-6, IL-1B, IL-8, TNF, APOA1, APOA2, APOB, APOC3, APOE, and HP) were identified and the enriched GO terms were examined. Our study highlighted the importance of the chemical barrier of saliva in the development of OSCC.

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Section: Amylases and Mucins In The Chemical Barrier Of Patients With...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Salivary Chemical Barrier Proteins in Oral Squamous Cell Carcinoma—Alterations in the Defense Mechanism of the Oral Cavity

Kalló,

Bertalan,

Márton

et al. 2023

IJMS

Self Cite

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The interaction of innate immune and adaptive immune system

Wang,

Lan,

Benlagha

et al. 2024

MedComm

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The innate immune system serves as the body's first line of defense, utilizing pattern recognition receptors like Toll‐like receptors to detect pathogens and initiate rapid response mechanisms. Following this initial response, adaptive immunity provides highly specific and sustained killing of pathogens via B cells, T cells, and antibodies. Traditionally, it has been assumed that innate immunity activates adaptive immunity; however, recent studies have revealed more complex interactions. This review provides a detailed dissection of the composition and function of the innate and adaptive immune systems, emphasizing their synergistic roles in physiological and pathological contexts, providing new insights into the link between these two forms of immunity. Precise regulation of both immune systems at the same time is more beneficial in the fight against immune‐related diseases, for example, the cGAS–STING pathway has been found to play an important role in infections and cancers. In addition, this paper summarizes the challenges and future directions in the field of immunity, including the latest single‐cell sequencing technologies, CAR‐T cell therapy, and immune checkpoint inhibitors. By summarizing these developments, this review aims to enhance our understanding of the complexity interactions between innate and adaptive immunity and provides new perspectives in understanding the immune system.

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A multi-task positive-unlabeled learning framework to predict secreted proteins in human body fluids

He,

Wang,

Xie

et al. 2023

Complex Intell. Syst.

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Body fluid biomarkers are very important, because they can be detected in a non-invasive or minimally invasive way. The discovery of secreted proteins in human body fluids is an essential step toward proteomic biomarker identification for human diseases. Recently, many computational methods have been proposed to predict secreted proteins and achieved some success. However, most of them are based on a manual negative dataset, which is usually biased and therefore limits the prediction performances. In this paper, we first propose a novel positive-unlabeled learning framework to predict secreted proteins in a single body fluid. The secreted protein discovery in a single body fluid is transformed into multiple binary classifications and solved via multi-task learning. Also, an effective convolutional neural network is employed to reduce the overfitting problem. After that, we then improve this framework to predict secreted proteins in multiple body fluids simultaneously. The improved framework adopts a globally shared network to further improve the prediction performances of all body fluids. The improved framework was trained and evaluated on datasets of 17 body fluids, and the average benchmarks of 17 body fluids achieved an accuracy of 89.48%, F1 score of 56.17%, and PRAUC of 58.93%. The comparative results demonstrate that the improved framework performs much better than other state-of-the-art methods in secreted protein discovery.

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Chemical Barrier Proteins in Human Body Fluids

Cited by 4 publications

References 180 publications

Salivary Chemical Barrier Proteins in Oral Squamous Cell Carcinoma—Alterations in the Defense Mechanism of the Oral Cavity

Salivary Chemical Barrier Proteins in Oral Squamous Cell Carcinoma—Alterations in the Defense Mechanism of the Oral Cavity

The interaction of innate immune and adaptive immune system

A multi-task positive-unlabeled learning framework to predict secreted proteins in human body fluids

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