Chemical changes of human knee joint menisci in various stages of degeneration.

Herwig, J.; Egner, E.; Buddecke, Eckhart

doi:10.1136/ard.43.4.635

Cited by 253 publications

(228 citation statements)

References 17 publications

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“…Given that the mechanical properties of the TMJ disc are largely dependent on the collagen fibre organization, proteoglycan composition and the interaction of these components with the tissue fluid, and that the initial effect of collagen degradation in articular tissues is an increase in their water content, it is reasonable to believe that early degenerative changes within the disc would be reflected in the measurement of its diffusion properties. [34][35][36] Our quantitative results encourage the use of DTI for comparison of similar measurements obtained from the TMJ discs of experimentally induced disease or inflammation in animal models such as the miniature pig model that correlates degenerative joint disease following intraoral splint wear described by Sindelar and coworkers. 37,38 In regards to the use of DTI, a much higher magnetic field strength than is currently approved for clinical studies was used.…”

Section: Discussionsupporting

confidence: 58%

High-resolution magnetic resonance imaging and diffusion tensor imaging of the porcine temporomandibular joint disc

Benavides¹,

Bilgen²,

Al-Hafez³

et al. 2009

Dentomaxillofacial Radiology

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Objectives: Diffusion tensor imaging (DTI) is an MRI modality for characterizing the property, microstructural organization and function in tissues such as the brain and spinal cord. Prior to this investigation, DTI had not been adapted for studies of the temporomandibular joint (TMJ) disc. Objectives were to test the feasibility of DTI to evaluate the porcine TMJ disc and to use DTI to observe differences in magnitude of anisotropy of water diffusion between TMJ disc regions. Methods: Five adult pig TMJs were scanned on a 9.4 Tesla horizontal bore MRI scanner using an inductively coupled surface coil. High-resolution gradient-echo and diffusionweighted spin-echo based images were obtained. The mean diffusivity and fractional anisotropy (FA) were computed in different regions of the disc. Two observers were calibrated to review the two-dimensional and three-dimensional images. Polarized light microscopy was used as the gold standard for collagen fibre orientation. Results: In the sagittal plane, the mean diffusivity was higher in the posterior (1.28¡0.10610 23 mm 22 s 21 ) and anterior (1.27¡0.08610 23 mm 22 s 21 ) bands compared with the intermediate zone (0.96¡0.01610 23 mm 22 s 21 ), and the FA index was also lowest in the intermediate zone. In the coronal plane, the mean diffusivity was higher in the medial (1.42¡0.01610 23 mm 22 s 21 ) and lateral (1.21¡0.12610 23 mm 22 s 21 ) aspects than in the centre (1.09¡0.08610 23 mm 22 s 21 ), and the FA index was also lowest in the centre. Conclusions: DTI is a useful method for non-invasively characterizing the structure/ property relationships of the porcine TMJ disc.

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Section: Discussionsupporting

confidence: 58%

High-resolution magnetic resonance imaging and diffusion tensor imaging of the porcine temporomandibular joint disc

Benavides¹,

Bilgen²,

Al-Hafez³

et al. 2009

Dentomaxillofacial Radiology

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“…The meniscus composed of the collagen fibrils arranged with a certain orientation can provide great elasticity, and they have the ability to withstand compression forces. [1][2][3][4][5][6] Some studies by Aspcen et al, 1 Bullough et al, 3 and Kummer 7 have depicted the normal meniscal microstructure and its collagen fibril texture by the use of different methods. Despite a few minor disagreements, 1,3,7 their concurrent view is that the circumferential fibrils at the peripheral site can properly accommodate hoop tension from the weight-bearing function.…”

mentioning

confidence: 99%

“…[10][11][12] It is easily torn and caught between the femur and the tibia because of its typical shape. 4,[10][11][12][13] Tear patterns of discoid menisci are more variable than the tear pat-terns of the normal meniscus. 10,13 These tear patterns are likely related to the collagen fibril arrangement of the discoid meniscus as compared with those in the normal meniscus.…”

mentioning

confidence: 99%

Collagenous Fibril Texture of the Discoid Lateral Meniscus

Cui

Min

2007

Arthroscopy: The Journal of Arthroscopic & Related Surgery

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“…7,8 Meniscal tissue is principally composed of water, collagens, and proteoglycans in approximate bulk mass proportions of 72%:22%:1%. 9 Collagens predominate at 60-70% of the dry tissue weight where Type I collagen has the highest concentration and Type II, III, V, and VI 2 are also present. Scanning electron microscopy (SEM) has previously revealed a complex arrangement of human meniscal collagen in three distinct layers 10 : (1) a fibril network covering the femoral and tibial surfaces, (2) a lamellar layer oriented towards the femoral and tibial surface, and (3) a central main portion composed of circumferentially oriented fibers along with occasional radial tie fibers.…”

mentioning

confidence: 99%

Meniscus structure in human, sheep, and rabbit for animal models of meniscus repair

Chevrier

Nelea

Hurtig

et al. 2009

Journal Orthopaedic Research

186

174

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Meniscus injury is a frequently encountered clinical orthopedic issue and is epidemiologically correlated to osteoarthritis. The development of new treatments for meniscus injury is intimately related to the appropriateness of animal models for their investigation. The purpose of this study was to structurally compare human menisci to sheep and rabbit menisci to generate pertinent animal models for meniscus repair. Menisci were analyzed histologically, immunohistochemically, and by environmental scanning electron microscopy (ESEM). In all species, collagen I appeared throughout most menisci, but was absent from the inner portion of the tip in some samples. Collagen II was present throughout the inner main meniscal body, while collagen VI was found in pericellular and perivascular regions. The glycosaminoglycan-rich inner portion of menisci was greater in area for rabbit and sheep compared to human. Cells were rounded in central regions and more fusiform at the surface, with rabbit being more cellular than sheep and human. Vascular penetration in rabbit was confined to the very outermost region (1% of meniscus length), while vessels penetrated deeper into sheep and human menisci (11-15%). ESEM revealed a lamellar collagenous structure at the articulating surfaces of sheep and human menisci that was absent in rabbit. Taken together, these data suggest that the main structural features that will influence meniscus repair-cellularity, vascularity, collagen structure-are similar in sheep and human but significantly different in rabbit, motivating the development of ovine meniscus repair models. ß

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Chemical changes of human knee joint menisci in various stages of degeneration.

Cited by 253 publications

References 17 publications

High-resolution magnetic resonance imaging and diffusion tensor imaging of the porcine temporomandibular joint disc

High-resolution magnetic resonance imaging and diffusion tensor imaging of the porcine temporomandibular joint disc

Collagenous Fibril Texture of the Discoid Lateral Meniscus

Meniscus structure in human, sheep, and rabbit for animal models of meniscus repair

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