Chemical characteristics and targeted encapsulated Cordia myxa fruits extracts nanoparticles for antioxidant and cytotoxicity potentials

Abstract

A promising Cordia myxa fruit (CMF) extract targets an additional incorporation in functional foods. It retains appropriate health welfares owing to its antioxidant properties with limited incorporation in food matrices due its hydrophobicity. Therefore, CMF extract micro- and nanocapsulation was performed to protect and facilitate consistency of produced hydrophobic foods matrices. Furthermore, to determine its phytochemicals, antioxidant, and cytotoxic effects by applying analytical HPLC, FRAP and SRB assay, respectively. HPLC analysis of the tested extracts revealed the presence of, 25.59 ± 1.78 mg catechin/g, 69.68 ± 4.20 mg quercetin/g, and 112.72 ± 8.38 mg gallic acid/g extract. The CMF extract displayed a potent DPPH radicals' scavenger and FRAP high reduction capability in a dose-dependent manner. The potent pharmacological activities of CMF extract may be ascribed to high concentration of polyphenolics including flavonoids which strongly reported to possess an antitumor and antioxidant activities. To confirm the efficient CMF incorporation in micro- and nanosystems and their thermal stabilities to withstand the high temperatures applied during some food processing. DSC of the apparent melt of non-capsulated CMF and encapsulated forms (MCMF and NCMF) in sodium alginate gel and beads was studied. Results showed that melting point of CMF extract (86.17 °C) indicating its inability whereas the MCMF and NCMF melting points (226.45 and 383.87 °C, respectively) demonstrating the capability of expending alginate – packaging material to shield the vital active compounds of C. myxa fruit to be applied in different targeted delivery products especially that disclosed to high thermal treatments.

Spent Coffee Grounds Valorization as Bioactive Phenolic Source Acquired Antifungal, Anti-Mycotoxigenic, and Anti-Cytotoxic Activities

“…Plates were washed three times with 1% acetic acid and air-dried overnight. Then, 150 μL of 10 mM trisaminomethane (TRIS) was added to dissolve the protein-bound SRB stain; the absorbance was measured at 540 nm using a BMG LABTECH ® -FLUOstar Omega microplate reader (Ortenberg, Germany) [45].…”

The Impact of Innovative Plant Sources (Cordia myxa L. Fruit (Assyrian Plum) and Phoenix dactylifera L. Biowaste (Date Pit)) on the Physicochemical, Microstructural, Nutritional, and Sensorial Properties of Gluten-Free Biscuits

“…The antioxidant potential of flour blends and biscuit samples was due to the presence of antioxidants and bioactive compounds in DPF and APF. Furthermore, Habib et al [ 51 ] and El-Massry et al [ 52 ] suggested that epicatechin, catechin, gentisic acid, and chrysin were the phytochemicals present in DPF and APF with a potent antioxidant potential. The mechanism responsible for the antioxidant activity of the samples was linked with the availability of antioxidants present in DPF and APF, which function as reducing agents and neutralize the formation of the free-radical chain reaction by the donation of electrons, which ultimately restricting the synthesis of peroxides [ 28 ].…”

Anticancer Activity of Cordia dichotoma against a Panel of Human Cancer Cell Lines and Their Phytochemical Profiling via HPLC and GCMS

“…The extract inhibited cell proliferation less effectively against the HepG2 cell line. Further, micro and nanocapsules showed a very low cytotoxicity [ 33 ]. In our current study, the growth inhibition of various extracts and fractions deviated somewhat from that described in the literature.…”