Chemical Characterization and Anti-Inflammatory Activity of Phytoconstituents from Swertia alata

Bajaj, Sakshi; Fuloria, Shivkanya; Subramaniyan, Vetriselvan; Meenakshi, Dhanalekshmi Unnikrishnan; Wakode, Sharad; Kaur, Avneet; Bansal, Himangini; Manchanda, Satish; Kumar, Sachin; Fuloria, Neeraj Kumar

doi:10.3390/plants10061109

Cited by 17 publications

(9 citation statements)

References 45 publications

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“…Other research shows that among the two phytoisolates of Swertia alata, the compound SA-4 has high anti-inflammatory potential and offers less ulcerogenic and less gastric irritant effect [29]. The results of this study imply that avocado leaf extract can be used and developed as a source of antioxidants that play a role in the regeneration of pancreas cells that degenerate due to high blood glucose levels.…”

Section: Discussionmentioning

confidence: 65%

The Avocado (Persea americana Mill.) Leaf Extract on Streptozotocin-induced Pancreatic Cell Regeneration of White Rats (Rattus norvegicus)

Rahman

Tangkas

Sabang

et al. 2021

Open Access Maced J Med Sci

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Objectibe The rate of pancreatic cell regeneration after avocado leaf extract intervention in a diabetic animal model induced by streptozotocin was investigated in this study. Method: Experimental study was conducted on 18 male white rats as subjects, which were divided into 6 groups, 3 animals of each. Those were G1 (Feed + Streptozotocin + 10% Sucrose + 100 mg/kg b.w. of extract + 0.5% NaCMC), G2 (Feed + Streptozotocin + 10% Sucrose + 150 mg/kg b.w. of extract + 0.5% NaCMC), G3 (Feed + Streptozotocin + 10% Sucrose + 200 mg/kg b.w. of extract + 0.5% NaCMC), G4 (Feed + Streptozotocin + 10% sucrose + 0.5% Na-CMC), G5 (Feed + Streptozotocin + 10% sucrose + Glibenclamid + 0.5% Na-CMC), G6 (Normal healthy animal + Feed). Results: The pancreatic cells damage in animal diabetic model, G1 = 1.67 (moderate cell damage); G2 = 1.00 (mild cell damage); G3 = 0.33 (no damage); G4 = 3.00 (severe cell damage); G5 = 0.33 (no damage); G6 = 0.33 (no damage). Conclusion: The dose of 200 mg/kg b.w. of avocado leaf extract contributed the most significant recovery of pancreatic cell of diabetic animal induced with streptozotocin, equivalent to glibenclamide.

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Section: Discussionmentioning

confidence: 65%

The Avocado (Persea americana Mill.) Leaf Extract on Streptozotocin-induced Pancreatic Cell Regeneration of White Rats (Rattus norvegicus)

Rahman

Tangkas

Sabang

et al. 2021

Open Access Maced J Med Sci

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“…In vitro histamine release inhibition by saponins has also been documented [2]. Thus, HU's analgesic effect may have been caused by the presence of these biologically active components [22][23][24][25][26][27][28].…”

Section: Fig 3 Values Of Pain Chemicals Of Extract In Study Animalsmentioning

confidence: 99%

Jack Fruit: An Estimation of Hunteria Umbellata Fruit Extract against Formalin Induced Nociception

Charles

Blessing

Charles

et al. 2023

JAMMR

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The purpose of the study is to ascertain the impact of ethanolic fruit extract from Hunteria umbellata on formalin-induced nociception in Wistar rats. Six sets of thirty Wistar rats, weighing 110.7 to 169.4 g each, were employed for the investigation. Group 1 functioned as the control group and was given nothing except unlimited amounts of rat food and water. Formalin was administered just to Group 2, which served as the FOG. Group 3 rats were given the standard drug group (SDG). Group 4 rats received 50 mg of Hunteria umbellata fruit extract per kilogramme of body weight. Group 5 rats received 100 mg of Hunteria umbellata fruit extract per kilogramme of body weight. Group 6 rats received 150 mg of Hunteria umbellata fruit extract per kilogramme of body weight. The experimental rats were given 50L of a 2% formaldehyde solution subcutaneously into their left hind paws an hour after extract and medication administration in order to cause pain. The duration of paw licking was immediately used to identify the spontaneous nociceptive behaviour. Following a 14-day period of treatment, samples were taken and tested for signs of pain. The significance level was set at p 0.05 after post hoc LSD and SPSS analysis of the data. The outcome showed that, in contrast to the formalin only group, the extract (LDEG, MDEG, HDEG) significantly enhanced (p0.05) the reaction time of nociceptive behaviours (FOG). In contrast to the control group, serum nociceptive molecules considerably (p 0.05) increased in the formalin only group (FOG). In conclusion, the extract proved useful for treating nociception by traditional medical professionals (herbalists).

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“…Disease modifying anti-rheumatic drugs (DMARDs) employed by some patients to manage this condition also cause severe adverse effects such as increased possibility of severe infections, retinopathy, hepatotoxicity among others 11 . Due to the side effects associated with the long term use of NSAIDS, it is imperative that newer agents are developed and natural plants are a likely source 12 .…”

Section: Pharmaceutical Sciences Asiamentioning

confidence: 99%

Anti-arthritic activity of solvent extracts of the bulbs of Crinum pedunculatum R.Br.

Doe¹,

Danquah²,

Ossei³

et al. 2022

Pharm Sci Asia

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Crinum pedunculatum (R.Br) has been used by traditional medicine practitioners in Ghana for the topical management of inflammation and associated disorders. This study investigated the anti-arthritic activity of the methanol, ethanol and ethyl acetate extract of the bulbs of Crinum pedunculatum using Sprague Dawley rats. The anti-arthritic activity of Crinum pedunculatum at various doses (100, 200 and 400 mg/kg) was evaluated using Complete Freund's Adjuvant (CFA) in rat model. After successful induction of the arthritis, the paw oedema, hematological parameters, pro-inflammatory cytokines and arthritis marker were assessed. Also, the radiological and histopathological evaluations were also performed. There was a significant inhibition (P<0.01) of paw oedema after treatment with 100, 200 and 400 mg/kg of the methanol, ethanol and ethyl acetate Crinum pedunculatum extracts relative to the control. There was also a significant increase in haemoglobin and RBC levels as well as a decrease in WBC count. All the extracts of Crinum pedunculatum decreased IL-6 and Rheumatoid factor serum concentrations and improved joint and cartilage destruction in both contralateral and ipsilateral paw of CFAinduced rats. Significant anti-arthritic activity was observed by the 200 and 400 mg/kg ethanol and methanol Crinum pedunculatum extract. This study confirms that the bulb of Crinum pedunculatum has an anti-arthritic potential and the findings justify the folkloric use the plant as an anti-inflammatory agent.

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Chemical Characterization and Anti-Inflammatory Activity of Phytoconstituents from Swertia alata

Cited by 17 publications

References 45 publications

The Avocado (Persea americana Mill.) Leaf Extract on Streptozotocin-induced Pancreatic Cell Regeneration of White Rats (Rattus norvegicus)

The Avocado (Persea americana Mill.) Leaf Extract on Streptozotocin-induced Pancreatic Cell Regeneration of White Rats (Rattus norvegicus)

Jack Fruit: An Estimation of Hunteria Umbellata Fruit Extract against Formalin Induced Nociception

Anti-arthritic activity of solvent extracts of the bulbs of Crinum pedunculatum R.Br.

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